Our research
Below we summarise research activities in the Bioinformatics Core, focusing on projects in the areas of genome analysis, translational medicine, and visual analytics.
Genome analysis
The Genome Analysis team performs large-scale genomic and genetic analyses in the fields of complex and rare human diseases, in particular Parkinson’s disease (PD) and genetic epilepsies. It is involved in systems genetics projects in humans and other model organisms, works on computational methods to understand the host-microbe interactions, and has developed reproducible workflows for large-scale microbiome multi-omics studies (in close collaboration with the Systems Ecology group of Prof. Paul Wilmes).
| Project | Topic | Contact |
|---|---|---|
| Epi25, For 2715, ILAE Genomics | Epilepsy genomics | Patrick May Roland Krause |
| Treat-ION, SOLVE-RD | Epilepsy genomics | Patrick May |
| LRRK2 family genomics | PD genomics | Patrick May |
| FOR 2488, NCER-PD, JPND Courage PD, GP2, MiRisk-PD | PD genetics | Patrick May |
| MICROH DTU, metaPUF, IMP, Binny | Microbiome bioinformatics | Patrick May |
| CLIMAFA | Fanconi anemia genetics | Patrick May |
| CRIMTYP | Forensic genetics | Patrick May |
Translational medicine
We take part in national and international research projects handling complex and sensitive data in translational medicine. We focus on data harmonisation, integration, and long-time storage for bioinformatic analysis workflows. We apply clinical and omics data standards, controlled vocabularies and ontologies, allowing combining and exploring multi-dimnensional datasets.
| Project | Topic | Contact |
|---|---|---|
| HeBA | Longitudinal cohort Ageing | Venkata Satagopam |
| COVIRNA | COVID-19 cohort Cardiovascular risk diagnosis | Venkata Satagopam |
| PREADAPT | Dementia Neuroinflammation | Venkata Satagopam |
| HeartMed | Cardiovascular disease Translational medicine | Irina Balaur |
| BIOMAP | Skin diseases Translational medicine | Venkata Satagopam |
| ReDiRECt | Bladder cancer Drug repurposing | Reinhard Schneider |
| ImmUniverse | Ulcerative Colitis Atopic Dermatitis Translational medicine | Xinhui Wang |
Visual analytics
We offer expertise and tools for visualisation, visual exploration, and analytics of complex biological mechanisms. We construct diagrams of molecular mechanisms affected by pathology of different diseases (disease maps), focusing on neurodegeneration and immune pathways.
| Project | Topic | Contact |
|---|---|---|
| Parkinson’s disease map | Parkinson’s disease Application of a disease map | Marek Ostaszewski |
| BY-COVID | COVID-19 Application of a disease map | Marek Ostaszewski |
| imSAVAR | Adverse Outcome Pathways Data integration, disease maps | Venkata Satagopam |
| MIRIADE | Dementia Data integration, disease maps | Marek Ostaszewski |
| GLIOTRAIN | Glioblastoma Application of a disease map | Reinhard Schneider |
| SYSCID | Chronic inflammatory diseases Data integration, disease maps | Venkata Satagopam |