Improved therapeutic options for cancer patients

The vast majority of cancer diseases are difficult to treat and durable responses to treatment or curing cancer is still a clinical challenge. Every tumor is unique, heterogeneous and quickly evolving. To find better treatments and cures, a lot of effort is put into personalized cancer therapies. Several translational projects, in collaboration with local and international clinical partners, aim at finding treatments that are specifically designed to target cancer in individual patients. The affinity and the effects of the drugs are assessed in cell lines, patient-derived organoids, in vivo and in innovative human 3D models by using several assays such as BRET, confocal microscopy, dose-response relationship, proliferation and invasion assays, robotic drug screening, etc.