The rodent facility has been established to assist researchers in the development and analysis of various in vivo models including humanized and germ-free animals. The facility has the capacity to house more than 100 different mouse lines in 1200 IVC cages in the Breeding barrier under SOPF status. The Experimental barrier with a capacity for 800 mouse cages, is dedicated to studies on transgenic rodents and offers the possibility to realize BSL-2 activities and housing xenograft models. Genetically modified rodent lines can be maintained either as live animals or as cryopreserved sperm or embryos. The facility offers the possibility of running a broad number of experimental procedures on the premises, including stereotaxic surgical procedures, behavior assessments (open field, catwalk, DVC), and multi-photon microscopy. Additionally, humanized mouse models can be provided within an SPF environment. The Germ-free Unit is established within the Breeding barrier to ensure a controlled health status. For colonization studies, germ-free mice can be inoculated with a suspension of a specific microbe (mono-colonization), a defined finite group of microbes, or a polymicrobial mixture.

Email: LCSB-rodents [at] uni.lu