Research Group Integrative Cell Signalling

Recent publications

  1. Farina, S., Voorsluijs, V., Fixemer, S., Bouvier, D. S., Claus, S., Ellisman, M. H., Bordas, S. P. A. & Skupin, A. Mechanistic multiscale modelling of energy metabolism in human astrocytes reveals the impact of morphology changes in Alzheimer’s Disease. PLOS Computational Biology 19, e1011464 (2023).
  2. Randic, T., Magni, S., Philippidou, D., Margue, C., Grzyb, K., Preis, J. R., Wroblewska, J. P., Nazarov, P. V., Mittelbronn, M., Frauenknecht, K. B. M., Skupin, A. & Kreis, S. Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response. Cell Reports 42, 112696 (2023).
  3. Proverbio, D., Kemp, F., Magni, S., Ogorzaly, L., Cauchie, H.-M., Gonçalves, J., Skupin, A. & Aalto, A. Model-based assessment of COVID-19 epidemic dynamics by wastewater analysis. Science of The Total Environment 827, 154235 (2022).
  4. Novak, G., Kyriakis, D., Grzyb, K., Bernini, M., Rodius, S., Dittmar, G., Finkbeiner, S. & Skupin, A. Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson’s disease. Commun Biol 5, 1–19 (2022).
  5. Fixemer, S., Ameli, C., Hammer, G., Salamanca, L., Uriarte Huarte, O., Schwartz, C., Gérardy, J.-J., Mechawar, N., Skupin, A., Mittelbronn, M. & Bouvier, D. S. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies. Acta Neuropathologica Communications 10, 36 (2022).

Key publications

  1. Tiraboschi, E., Martina, S., van der Ent, W., Grzyb, K., Gawel, K., Cordero-Maldonado, M. L., Poovathingal, S. K., Heintz, S., Satheesh, S. V., Brattespe, J., Xu, J., Suster, M., Skupin, A. & Esguerra, C. V. New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome.Epilepsia (2020). doi:10.1111/epi.16456
  2. Moein, M., Grzyb, K., Gonçalves Martins, T., Komoto, S., Peri, F., Crawford, A. D., Fouquier d’Herouel, A. & Skupin, A. CaSiAn: a Calcium Signaling Analyzer tool. Bioinformatics 34, 3052–3054 (2018).
  3. Mojtahedi, M., Skupin, A., Zhou, J., Casta??o, I. G., Leong-Quong, R. Y. Y., Chang, H., Trachana, K., Giuliani, A. & Huang, S. Cell Fate Decision as High-Dimensional Critical State Transition. PLOS Biology 14, e2000640 (2016).
  4. Tan, Z., Hays, M., Cromie, G. A., Jeffery, E. W., Scott, A. C., Ahyong, V., Sirr, A., Skupin, A. & Dudley, A. M. Aneuploidy underlies a multicellular phenotypic switch. Proceedings of the National Academy of Sciences 110, 12367–12372 (2013).
  5. Taufiq-Ur-Rahman, Skupin, A., Falcke, M. & Taylor, C. W. Clustering of InsP3 receptors by InsP3retunes their regulation by InsP3 and Ca2+. Nature 458,655–659 (2009).

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