Multiscale organisation of life
We are investigating the multiscale organisation of life by complementary approaches from non-equilibrium physics, mechanistic multiscale modelling, and biological experiments. A specific focus is the organization of energy metabolism and its impact on cellular development in health and disease conditions.
The role of energy metabolism in cell fate
Multiscale Biology
Our general approach is to combine state-of-the-art imaging and single cell techniques with concepts from non-equilibrium physics, mechanistic modelling and bioinformatics analyses to investigate how the emergent behaviour of cells, organs and organisms originates from molecular entities. To understand the underlying cell signalling mechanisms, we focus on live cell imaging and multi-scale simulations with consideration of genetic constrains.
Our major interests are signalling pathways related to neurodegeneration with a particular focus on mitochondrial dysfunction and dynamic coupling between energy metabolism and cell signalling such as calcium dynamics.