Her lab dissects how metabolism and the tumor microenvironment, including stromal cells and the microbiome, drive colorectal cancer (CRC) progression and therapy resistance. In partnership with national hospitals, IBBL, and LNS, she spearheaded a CRC biobank of 250+ high-quality patient samples, powering rigorous translational studies. Her team has established patient-derived 3D organoid assays and state-of-the-art in vivo models to understand mechanisms underlying tumorigenesis and identify potential novel therapeutic strategies.
Dr. Letellier has authored 51+ publications (h-index 34, 4,656 citations), secured €10M+ in mostly competitive external funding, and contributed to three patent filings (two as lead inventor). She also directs Molecular Medicine II and leads Practicals in Protein Structure and Biochemistry in the Integrated Systems Biology Master. ORCID iD: 0000-0001-8242-9393.