Research project KRuptor

Development of a Kras signaling complex disruptor and degrader (KRuptor)

The project at a glance

  • Start date:
    15 Sep 2023
  • Duration in months:
    48
  • Funding:
    FNR
  • Principal Investigator(s):
    Daniel ABANKWA

About

Recent drug development approaches are not only aiming at blocking the active site of a target protein, but to entirely degrade the target. This is what we will apply as one strategy to ablate the activity of oncogenic KRAS in this PhD project. The second strategy will be to disrupt KRAS signaling complexes. We will provide important proof-of-concept data on how to drug-target KRAS signaling complexes in the membrane. Such data are relevant to motivate future dedicated drug development efforts.

Organisation and Partners

  • Department of Life Sciences and Medicine
  • Faculty of Science, Technology and Medicine (FSTM)

Project team

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