Personal functional profiling for drug discovery in melanoma and colorectal cancer (MelCol-PFP)

The project at a glance

Start date:

01 Apr 2021
Duration in months:

48
Funding:

FNR / The Vera Nijs and Jens Erik Rosborg Foundation (FVNJER)
Principal Investigator(s):

Stephanie Kreis

Elisabeth Letellier

Barbara Klink (external)

Michel Mittelbronn (external)

About

This project investigates two different cancers in parallel: melanoma and colorectal cancer (CRC). The proposed project, which combines genetic analysis and personalized drug library screening, offers a unique setup where efficient but novel drugs or combinations can be found within weeks in a personalised way. Additionally, this project will lead to a better understanding of resistance mechanisms that occur in melanoma and CRC after standard and identified drug treatments. This knowledge may potentially help to select new drugs and drug combinations to overcome therapy resistance. Objective 1: Establishment of a semiautomated melanoma/CRC drug-testing pipeline for routine medium- to high-throughput drug testing (set up phase). Objective 2: Establishment of clinical reporting lines to benefit late stage melanoma and CRC patients (translational phase). Objective 3: Identification of deregulated transcriptional networks and molecular mechanisms involved in successful drug treatments and drug resistance (experimental phase).

Organisation and Partners

Department of Life Sciences and Medicine
Faculty of Science, Technology and Medicine (FSTM)
Molecular Disease Mechanisms
Signal Transduction Group
Luxembourg Institute of Health
Laboratoire National de Santé Luxembourg

Project team

Stephanie Kreis

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Elisabeth Letellier

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Barbara Klink

Laboratoire National de Santé Luxembourg
Michel Mittelbronn

Laboratoire National de Santé Luxembourg
Cristian Angeli (PhD student)

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Joanna Wroblewska (scientist)

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Christiane Wurth-Margue (senior scientist)

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Demetra Philippidou (technician)

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Sura Atatri

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Meritxell Bao Cutrona (Disease Modeling & Screening Platform)

Luxembourg Institute of Health
Bruno Dos Santos Rodrigues (Disease Modeling & Screening Platform)

Luxembourg Institute of Health