Faculty of Science, Technology and Medicine
Faculty of Law, Economics and Finance
Faculty of Humanities, Education and Social Sciences
Interdisciplinary Centre for Security, Reliability and Trust
Luxembourg Centre for Systems Biomedicine
Luxembourg Centre for Contemporary and Digital History
Luxembourg Centre for European Law
Luxembourg Centre for Socio-Environmental Systems
About this event
Explore the forefront of neuroscience with the LCSB Neuroscience Lecture Series, featuring scientific presentations from internationally renowned experts in various disciplines of neuroscience.
Meet the speaker! One-on-one meeting opportunities with the speaker can be arranged by emailing Murielle Moes.
Ferroptotic cell death propagation in the central nervous system
Ferroptosis is an iron-dependent, lipid-peroxidation-driven form of regulated cell death that has emerged as a key contributor to neurodegenerative diseases. Importantly, susceptibility to ferroptosis is highly cell-type specific within the central nervous system (CNS). In this talk, I will outline inflammation-induced, non-canonical signaling pathways in neurons that activate ferroptosis. The focus will be on maladaptive type II interferon signaling in neurons, which induces ferroptotic death through proteasomal and autophagic dysfunction. Furthermore, I will highlight emerging evidence that ferroptotic stress propagates across cell types via neuron-astrocyte signaling, amplifying tissue vulnerability beyond intrinsically susceptible neurons. Lastly, I will discuss the relevance of these inflammation-driven pathways in Alzheimer’s disease (AD), particularly how they can be captured by fluid and imaging biomarkers and how they contribute to interactions between vascular co-pathologies and accelerated AD progression. In summary, this talk will discuss cell-type-specific inflammatory ferroptosis signaling as a mechanistic link between neuroinflammation, neuronal vulnerability, and disease progression in AD.
About the speaker
Marcel S. Woo is a neurology resident at University Medical Center Hamburg-Eppendorf, group leader of the Translational Neurodegeneration Lab, and adjunct professor at McGill University. His research focuses on inflammatory cell-death propagation, biomarkers, and vascular co-pathologies in Alzheimer’s disease, integrating mechanistic neuroscience with clinical translation across human cohorts and models. He studied medicine at the UKE and did his postdoc in molecular neuroimmunology and computational neuroscience at the UKE and McGill University.
The Neuroscience Lecture Series is supported by the Schick Foundation.
