Research Group Gene Expression & Metabolism

Key publications

  1. Williams, E. G., Pfister, N., Roy, S., Statzer, C., Haverty, J., Ingels, J., Bohl, C., Hasan, M., Čuklina, J., Bühlmann, P., Zamboni, N., Lu, L., Ewald, C. Y., Williams, R. W., & Aebersold, R. (2022). Multiomic profiling of the liver across diets and age in a diverse mouse population. Cell Systems.
  2. Čuklina, J., Lee, C. H., Williams, E. G., Sajic, T., Collins, B. C., Rodriguez Martinez, M., Sharma, V. S., Wendt, F., Goetze, S., Keele, G. R., Wollscheid, B., Aebersold, R., & Pedrioli, P. G. A. (2021). Diagnostics and correction of batch effects in large-scale proteomic studies: a tutorial. Molecular Systems Biology.
  3. Williams, E. G., Wu, Y., Ryu, D., Kim, J. Y., Lan, J., Hasan, M., Wolski, W., Jha, P., Halter, C., Auwerx, J., & Aebersold, R. (2018). Quantifying and localizing the mitochondrial proteome across five tissues in a mouse population. Molecular & Cellular Proteomics, 17(8).
  4. Williams, E. G., Wu, Y., Jha, P., Dubuis, S., Blattmann, P., Argmann, C. A., Houten, S. M., Amariuta, T., Wolski, W., Zamboni, N., Aebersold, R., & Auwerx, J. (2016). Systems proteomics of liver mitochondria function. Science.
  5. Wu, Y., Williams, E. G., Dubuis, S., Mottis, A., Jovaisaite, V., Houten, S. M., Argmann, C. A., Faridi, P., Wolski, W., Kutalik, Z., Zamboni, N., Auwerx, J., & Aebersold, R. (2014). Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell, 158(6), 1415–1430.

Recent publications

  1. Li, X., Morel, J. D., Benegiamo, G., Poisson, J., Bachmann, A., Rapin, A., Sulc, J., Williams, E., Perino, A., Schoonjans, K., Bou Sleiman, M., & Auwerx, J. (2023). Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population. eLife.
  2. Xu, F., Ziebarth, J. D., Goeminne, L. J. E., Gao, J., Williams, E. G., Quarles, L. D., Makowski, L., Cui, Y., Williams, R. W., Auwerx, J., & Lu, L. (2023). Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response. Journal of Nutritional Biochemistry.
  3. Li, H., Perino, A., Huang, Q., von Alvensleben, G. V. G., Banaei Esfahai, A., Velazquez-Villegas, L. A., Gariani, K., Korbelius, M., Bou Sleiman, M., Sun, Y., Li, X., Bachmann, A., Williams, E. G., Ivanisevic, J., Auwerx, J., & Schoonjans, K. (2022). Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis. Cell Metabolism.
  4. Sharma, V. S., Fossati, A., Ciuffa, R., Buljan, M., Williams, E. G., Chen, Z., Shao, W., Pedrioli, P. G. A., Purcell, A. W., Rodriguez Martinez, M., Song, J., Manica, M., Aebersold, R., & Li, C. (2022). PCfun: a hybrid computational framework for systematic characterization of protein complex function. Briefings in Bioinformatics.
  5. Morel, J. D., Sauzéat, L., Goeminne, L. J. E., Pooja, J., Williams, E., Houtkooper, R., Aebersold, R., Auwerx, J., & Balter, V. (2022). The mouse metallomic landscape of aging and metabolism. Nature Communications.

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