IDAE - Integrative Data Analysis in Epilepsy - LCSB - University of Luxembourg I Uni.lu

The aim of this project is to find new biomarkers and thus facilitate the personalisation of treatment for epilepsy patients.

The project at a glance

Start date:

01 Jan 2023
Duration in months:

1
Funding:

Institute for Advanced Studies (IAS)
Principal Investigator(s):

Alexander Skupin

Jacques Klein

Massimiliano Esposito

About

Epilepsy has researchers puzzled. The disease, which is characterised by spontaneously occurring seizures, is one of the most widespread neurological afflictions. Yet its treatment is a huge challenge: many patients do not respond to any of the available drugs and others only to a laboriously adjusted combination of multiple drugs. The causes of epilepsy are also still largely unknown. Although scientists have identified more than 500 genetic mutations that may contribute to the development of the disease, this only provides part of the explanation. The IDAE project involves scientists from the Interdisciplinary Centre for Security, Reliability and Trust (SnT) and the Department of Physics (FSTM), as well as the Integrative Cell Signalling group at the LCSB led by Associate Prof. Alexander Skupin. To better understand epilepsy, the three teams are combining results from genetic research on zebrafish, realistic modelling of metabolic processes and data analyses using machine-learning algorithms. With this interdisciplinary approach, they hope to find new biomarkers and thus facilitate the personalisation of treatment for epilepsy patients.