Research Group Molecular Biophysics

Key publications

  1. *Yu, M., *Gruzinov, A., *Ruan, H., *Scheidt, T., Chowdhury, A., Giofre, S., Mohammed, A., Caria, J., Sauter, P. F., Svergun, D. & Lemke, E. A. (2024) A genetically encoded anomalous SAXS ruler to probe the dimensions of intrinsically disordered proteins. Accepted in Proc. Natl. Acad. Sci. U.S.A.
  2. *Brzezinski, M., Argudo, P. G., Scheidt, T., Yu, M., Lemke, E. A., Michels, J. J. & Parekh, S. H. (2025) Protein specific crowding accelerates aging in protein condensates. Biomacromolecules 26, 4: 2060-2075. Doi:10.1021/acs.biomac.4c00609
  3. *Schneider, M. M., *Scheidt, T., *Priddey, A. J., *Xu, C. K., Hu, M., Meisl, G., Devenish, S. R. A., Dobson, C. M., Kosmoliaptsis, V. & Knowles, T. P. J. (2023) Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum. Biosens. Bioelectron. 228. DOI: 10.1016/j.bios.2023.115196
  4. *Michels, J. J., Brzezinski, M., Scheidt, T., Lemke, E. A., & Parekh, S. H. (2022) Role of Solvent Compatibility in the Phase Behavior of Binary Solutions of Weakly Associating Multivalent Polymers. Biomacromolecules 23, 1: 349-364. DOI: 10.1021/acs.biomac.1c01301
  5. *Popper, B., Scheidt, T., & Schieweck, R. (2021) RNA-binding protein dysfunction in neurodegeneration. Essays Biochem. 65, 7: 975-986. DOI: 10.1042/EBC20210024
  6. *Scheidt, T., *Carozza, J. A., Kolbe, C. C., Aprile, F. A., Tkachenko, O., Bellaiche, M. M. J., Meisl, G., Peter, Q. A. E., Herling, T. W., Ness, S., Castellana- Cruz, M., Benesch, J. L. P., Vendruscolo, M., Dobson, C. M., Arosio, P., & Knowles, T. P. J. (2021) The binding of the small heat-shock protein αBcrystallin to fibrils of α-synuclein is driven by entropic forces. Proc. Natl. Acad. Sci. U.S.A. 118, 38. DOI: 10.1073/pnas.2108790118
  7. *Kartanas, T., Levin, A., Toprakcioglu, Z., Scheidt, T., Hakala, T. A., Charmet, J., & Knowles, T. P. J. (2021) Label-Free Protein Analysis Using Liquid Chromatography with Gravimetric Detection. Anal. Chem. 93, 5: 2848-2853. DOI: 10.1021/acs.analchem.0c04149
  8. *Linse, S., Scheidt, T., Bernfur, K., Vendruscolo, M., Dobson, C. M., Cohen, S. I. A., Sileikis, E., Lundqvist, M., Qian, F., O’Malley, T., Bussiere, T., Weinreb, P. H., Xu, C. K., Meisl, G., Devenish, S. R. A., Knowles, T. P. J., & Hansson, O. (2020) Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies. Nat. Struct. Mol. Biol. 27, 12: 1125-1133. DOI: 10.1038/s41594-020-0505-6
  9. *Scheidt, T., *Kartanas, T., Peter, Q., Schneider, M. M., Saar, K. L., Müller, T., Challa, P. K., Levin, A., Devenish, S., & Knowles, T. P. J. (2020) Multidimensional protein characterisation using microfluidic post-column analysis. Lab Chip 20, 2663- 2673. DOI: 10.1039/D0LC00219D
  10. *Scheidt, T., Łapińska, U., Kumita, J. R., Whiten, D. R., Klenerman, D., Wilson, M. R., Cohen, S. I. A., Linse, S., Vendruscolo, M., Dobson, C. M., Knowles, T. P. J., & Arosio, P. (2019) Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates. Sci. Adv. 5. DOI: 10.1126/sciadv.aau3112

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