Faculty of Science, Technology and Medicine
Faculty of Law, Economics and Finance
Faculty of Humanities, Education and Social Sciences
Interdisciplinary Centre for Security, Reliability and Trust
Luxembourg Centre for Systems Biomedicine
Luxembourg Centre for Contemporary and Digital History
Luxembourg Centre for European Law
Luxembourg Centre for Socio-Environmental SystemsMolecular biophysics of chaperone-mediated protein assembly
The Molecular Biophysics Group, led by Dr. Tom Scheidt, uses microfluidic and biophysical methods to explore how molecular chaperones regulate protein assembly and aggregation. The group will start in January 2026.
A glimpse into our research
Bridging scales: from molecules to neurodegeneration
We use microfluidic and biophysical techniques to bridge the gap between classical protein aggregation kinetics and the emerging concept of phase separation and nanometre-sized cluster formation. Our research focuses on the regulation of intrinsically disordered proteins, oligomer formation, and the conversion of condensates into pathological aggregates in neurodegeneration by molecular chaperones, particularly small heat shock proteins.
Small heat shock proteins modulate IDP morphology through dynamic, polydisperse oligomers that bind diverse targets via subunit exchange