About this event

Explore the forefront of neuroscience with the LCSB Neuroscience Lecture Series, featuring scientific presentations from internationally renowned experts in various disciplines of neuroscience.

Meet the speaker! One-on-one meeting opportunities with the speaker can be arranged by emailing Murielle Moes.

Microglia: roles beyond inflammation in different CNS disease states

The role of inflammatory mechansims in common neurological conditions is emerging. However, the mechanisms through which microglia, the main modulators of inflammation in the CNS shape neurovascular processes in diverse disease states, is not well understood. We have identified novel forms of microglia-neuron interactions, through which microglia sense neuronal activity and injury, while also modulate neuronal function. Microglia also shape vascular responses via specialized interactions, through which microglia modulate cerebral blood flow and support adaptation to cerebral hypoperfusion that commonly occurs in brain disorders. In the inflamed brain, altered microglia-neurovascular interactions are associated with diverse neurovascular pathologies. We systematically assess the key molecules that contribute to neurovascular modulation by microglia in the mouse and the human brain, to understand how different neurological conditions affect microglial states and what functional consequences this may have on disease outcomes. Understanding the molecular mechanisms of microglia-neurovascular interactions is likely to help the identification of novel therapeutic targets in common neurological disorders.

About the speaker

Ádám Dénes is a principal investigator at the HUN-REN Institute of Experimental Medicine (IEM), Budapest, Hungary. Research of his group focuses on the role of microglia in regulating neuronal activity and neurovascular responses in health and disease.