Explore the forefront of neuroscience with the LCSB Neuroscience Lecture Series, featuring scientific presentations from internationally renowned experts in various disciplines of neuroscience.
Meet the speaker! A networking aperitif with light snacks and refreshments will follow the presentation. Further one-on-one meeting opportunities with the speaker can be arranged by emailing Caroline Belot.
Role of microglia/macrophage CD300f lipid-binding immune receptor in ageing and Alzheimer’s Disease
Strong evidence shows that lipid-binding immune receptors such as TREM2 and CD300f participate in the regulation of microglia/macrophage phenotype, impacting the normal function of the nervous system and many physiopathological mechanisms. They limit the severity of inflammatory conditions by negatively regulating the innate immune system, participate in efferocytosis and synapse pruning, and are also key sensors of the extracellular space adjusting the immunometabolic status of the cells accordingly. We will discuss the role of CD300f in aging and Alzheimer’s Disease and how it regulates in vivo microglial/macrophage cell states, impacting on phagocytic function, detection of tissue damage, putative ligands, and intracellular signaling.
About the speaker
Hugo Peluffo is group leader of the Neuroimmune Interactions Laboratory at the Faculty of Medicine of the University of Barcelona. He has studied glial cell biology, immune receptors and neuroinflammation for many years and at different institutions such as the Universidad de la República and the Institut Pasteur de Montevideo (Uruguay), and the Autonomous University of Barcelona (Spain). His group is focused on the study of microglial/macrophage lipid-binding immune receptors and their function in modulating inflammation, immunometabolism, phagocytosis, and synaptic pruning.
The Neuroscience Lecture Series is supported by the Luxembourg National Research Fund (FNR) RESCOM Program (RESCOM24/18810230/Neurosciences_LS).
