Age-related genome instability in the etiopathogenesis of Parkinson’s disease: from bench to bedside
Aging is Parkinson’s disease the main risk factor. How ageing contributes to PD progression, however, is rudimentarily understood and ageing is rarely incorporated into Parkinson’s disease modelling. In my talk, I will discuss evidence obtained in our laboratories indicating how defective repair of nuclear DNA and consequent accumulation of DNA damage, fundamental mechanisms of ageing, contribute to Parkinson’s disease etiopathogenesis. I will also discuss the mechanisms governing metabolic rewiring upon DNA damage accumulation to foster cellular antioxidant resources. Finally, I will illustrate the translational value of our mechanistic findings and discuss how metabolic and DNA repair capacity variables may be useful to stratify patients and predict disease progression.
About the speaker
Pier Giorgio Mastroberardino is a principal investigator at the Erasmus Medical Centre Rotterdam and at IFOM, the AIRC Institute for Molecular Oncology in Milan. He is interested in mechanisms of Parkinson’s disease etiopathogenesis with particular attention to metabolism, genome stability, and their interplay. Additionally, he recently received financial support to investigate the complex interactions between neurons and cancer cells in tumour development. Pier Giorgio Mastroberardino also holds an executive MBA degree and is actively engaged in science valorisation.
