{"id":12541,"date":"2025-03-05T16:59:35","date_gmt":"2025-03-05T15:59:35","guid":{"rendered":"https:\/\/www.uni.lu\/research-en\/?post_type=research-projects&p=12541"},"modified":"2025-07-15T10:40:47","modified_gmt":"2025-07-15T08:40:47","slug":"amipd-astrocyte-metabolism-in-parkinsons-disease","status":"publish","type":"research-projects","link":"https:\/\/www.uni.lu\/research-en\/research-projects\/amipd-astrocyte-metabolism-in-parkinsons-disease\/","title":{"rendered":"AMiPD: Astrocyte Metabolism in Parkinson\u2019s Disease"},"content":{"rendered":"\n
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\nAMiPD: Astrocyte Metabolism in Parkinson\u2019s Disease<\/h1>\n<\/div>\n<\/header>\n
\n \n\"AMiPD_photo\"\n <\/figure>\n
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<\/p>\n\n\n

    \n\n<\/ul>\n<\/div>\n<\/div>\n <\/div>\n<\/section><\/div><\/section>\n\n\n\n
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    \n
    The project at a glance<\/h2>\n\n\n
    \n
      \n
    • \n \n
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      \n <\/use><\/svg><\/div>\n\n\n

      Start date:
      01 January 2025<\/strong><\/p>\n<\/div>\n<\/li>\n

    • \n \n
      \n
      \n <\/use><\/svg><\/div>\n\n\n

      Duration in months:
      36<\/strong>
      <\/p>\n<\/div>\n<\/li>\n

    • \n \n
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      \n <\/use><\/svg><\/div>\n\n\n

      Funding:
      IAS Luxembourg \/ European Commission<\/strong><\/p>\n<\/div>\n<\/li>\n

    • \n \n
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      \n <\/use><\/svg><\/div>\n\n\n

      Principal Investigator(s):
      Dr. Ilaria GOGLIA
      <\/strong><\/p>\n<\/div>\n<\/li>\n <\/ul>\n<\/div>\n\n\n\n

      \nAbout<\/h2>\n\n\n\n

      Growing evidence points to the alteration of astrocyte function and mitochondrial dysfunction as significant contributors to Parkinson\u2019s disease (PD) and \u03b1-synuclein (\u03b1-syn) pathology. The Astrocyte Metabolism in Parkinson\u2019s Disease (AMiPD) project aims to elucidate how \u03b1-syn pathology influences astrocytic metabolism and its subsequent effects on neurodegeneration in PD.<\/p>\n\n\n\n

      The project aims to use a multi-omics data approach to identify metabolic alterations in \u03b1-syn mutant astrocytes. The primary objective is to develop a multiscale computational model capable of simulating astrocytic metabolism, integrating spatial and morphological features to predict metabolic changes accurately. Experimental validation will include metabolomic profiling and mitochondrial characterization in astrocytes derived from iPSCs of \u03b1-syn mutation carriers, as well as post-mortem brain tissues.<\/p>\n\n\n\n

      This interdisciplinary approach bridges wet lab and computational biology, offering insights into PD pathogenesis and identifying potential therapeutic targets.<\/p>\n\n\n

      <\/div>\n\n\n

      This project has received funding from the European Union\u2019s Horizon Europe research and innovation programme under the Marie Sk\u0142odowska-Curie Actions grant agreement 101081455.<\/strong><\/p>\n\n\n

      <\/div>\n\n\n

      \nOrganisation and partners<\/h2>\n\n\n\n

      Faculty of Science, Technology and Medicine (FSTM)<\/strong>
      Luxembourg Centre for Systems Biomedicine (LCSB)<\/strong>
      Institute for Advanced Studies (IAS)<\/strong>
      European Commission<\/strong><\/p>\n\n\n

      \n \n

      \nProject team<\/h2>\n
        \n
      • \n
        \n
        \n
        \n \n\"Dr.\n <\/figure>\n <\/div>\n
        \n

        Dr. Ilaria GOGLIA<\/h3>\n

        Postdoctoral researcher<\/p>\n

        \n \n \n Learn more<\/span>\n <\/span>\n <\/use><\/svg> <\/a>\n<\/div>\n <\/div>\n <\/div>\n<\/div>\n<\/div><\/li>
      • \n
        \n
        \n
        \n \n\"Prof\n <\/figure>\n <\/div>\n
        \n

        Prof Anne GR\u00dcNEWALD<\/h3>\n

        Full professor \/ Chief scientist 1<\/p>\n

        \n \n \n Learn more<\/span>\n <\/span>\n <\/use><\/svg> <\/a>\n<\/div>\n <\/div>\n <\/div>\n<\/div>\n<\/div><\/li>
      • \n
        \n
        \n
        \n \n\"Prof\n <\/figure>\n <\/div>\n
        \n

        Prof St\u00e9phane BORDAS<\/h3>\n

        Full professor in Computational mechanics<\/p>\n

        \n \n \n Learn more<\/span>\n <\/span>\n <\/use><\/svg> <\/a>\n<\/div>\n <\/div>\n <\/div>\n<\/div>\n<\/div><\/li><\/ul>\n\n<\/div>\n\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"

        Growing evidence points to the alteration of astrocyte function and mitochondrial dysfunction as significant contributors to Parkinson\u2019s disease (PD) and \u03b1-synuclein (\u03b1-syn) pathology. The Astrocyte Metabolism in Parkinson\u2019s Disease (AMiPD)\u00a0project aims to elucidate how \u03b1-syn pathology influences astrocytic metabolism and its subsequent effects on neurodegeneration in PD.<\/p>\n

        The project aims to use a multi-omics data approach to identify metabolic alterations in \u03b1-syn mutant astrocytes. The primary objective is to develop a multiscale computational model capable of simulating astrocytic metabolism, integrating spatial and morphological features to predict metabolic changes accurately. Experimental validation will include metabolomic profiling and mitochondrial characterization in astrocytes derived from iPSCs of \u03b1-syn mutation carriers, as well as post-mortem brain tissues.<\/p>\n","protected":false},"author":203,"featured_media":12750,"parent":0,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"AMiPD","uluxPrePostTitle":"Research project","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"rpp_rp_identifier":"13088","rpp_taxonomies_in_sync":true},"research-project-status":[],"research-project-type":[],"field-of-interest":[],"organisation":[],"authorship":[203,329],"acf":[],"yoast_head":"\nAMiPD: Astrocyte Metabolism in Parkinson\u2019s Disease I Uni.lu<\/title>\n<meta name=\"description\" content=\"Growing evidence points to the alteration of astrocyte function and mitochondrial dysfunction as significant contributors to Parkinson\u2019s disease (PD) and \u03b1-synuclein (\u03b1-syn) pathology. 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