Systems biology is an interdisciplinary field that combines experimental and computational approaches to analyse complex biological systems and disease processes. It can help us understand how biological systems work and how they change under different conditions, such as diseases, drugs, or environmental factors. System Biology often employs high-throughput omics technologies, which measure the entire make-up of cells or tissues (e.g. genomics, transcriptomics, proteomics, metabolomics, etc.). For better visualization and analysis, the resulting complex data is often represented as networks, a graphical display of all interactions between the constituents.
This strategy requires a highly interdisciplinary research environment, with a strong collaboration amongst computer scientists, engineers, mathematicians, physicists, biologists and clinical scientists. At the LCSB, we use systems biology to tackle some of the most pressing challenges in neurodegenerative diseases, such as Alzheimer’s or Parkinson’s.