{"id":975,"date":"2024-05-30T16:49:20","date_gmt":"2024-05-30T14:49:20","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-fr\/?post_type=research-projects&p=975"},"modified":"2025-06-30T10:43:27","modified_gmt":"2025-06-30T08:43:27","slug":"fastcov","status":"publish","type":"research-projects","link":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/","title":{"rendered":"FastCoV : une \u00e9tude sur les b\u00e9n\u00e9fices potentiels du je\u00fbne pour le traitement du COVID long"},"content":{"rendered":"
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  • \n \n \n \n <\/svg>\n Contexte<\/span>\n <\/a>\n<\/li>\n
  • \n \n \n \n <\/svg>\n Protocole de l’\u00e9tude<\/span>\n <\/a>\n<\/li>\n
  • \n \n \n \n <\/svg>\n Partenaires<\/span>\n <\/a>\n<\/li>\n
  • \n \n \n \n <\/svg>\n Contact<\/span>\n <\/a>\n<\/li>\n <\/ul>\n <\/nav>\n<\/div>\n<\/div>\n\n\n<\/div>\n\n\n\n
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    Le syndrome post-COVID, ou COVID long, est une complication aigu\u00eb de l’infection par le SARS-CoV-2. Il survient dans environ 10 % des cas et repr\u00e9sente un enjeu significatif pour la sant\u00e9 publique. La dur\u00e9e et la gravit\u00e9 du COVID long sont tr\u00e8s variables et les sympt\u00f4mes, tels que la fatigue, des difficult\u00e9s respiratoires, des douleurs et des troubles cognitifs, affectent le quotidien et la qualit\u00e9 de vie des personnes touch\u00e9es. Bien que des traitements m\u00e9dicamenteux prometteurs soient en cours de d\u00e9veloppement, leur efficacit\u00e9 n’est pas encore prouv\u00e9e. Il est donc n\u00e9cessaire de trouver des alternatives.<\/p>\n\n\n\n

    Le je\u00fbne th\u00e9rapeutique pourrait constituer un traitement efficace et accessible. Il cible les processus inflammatoires et le d\u00e9s\u00e9quilibre du microbiote intestinal, deux caract\u00e9ristiques connues du COVID long.<\/p>\n\n\n\n

    \nLe projet de recherche FastCoV<\/strong><\/h2>\n\n\n\n

    Ce projet vise \u00e0 d\u00e9terminer si le je\u00fbne constitue un traitement appropri\u00e9 pour le COVID long, en \u00e9tudiant les effets d\u2019une restriction calorique sur les sympt\u00f4mes.<\/p>\n\n\n\n

    Une phase pilote avec 20 participants va tout d\u2019abord permettre d\u2019\u00e9valuer la faisabilit\u00e9 d’un essai clinique plus large. Pendant sept jours, les participants suivront un programme de je\u00fbne encadr\u00e9. Sur la base des r\u00e9sultats de cette phase pilote, 64 patients suppl\u00e9mentaires seront recrut\u00e9s pour l\u2019essai clinique principal. Ils suivront le m\u00eame protocole de je\u00fbne, apr\u00e8s lequel, un groupe de participants reprendra son alimentation normale, tandis qu’un autre groupe adoptera un r\u00e9gime anti-inflammatoire.<\/p>\n\n\n\n

    Cette \u00e9tude vise \u00e0 collecter des donn\u00e9es sur les effets de la restriction calorique sur les sympt\u00f4mes du COVID long et sur l\u2019\u00e9tat de sant\u00e9 des personnes touch\u00e9es. Elle permettra de savoir si les b\u00e9n\u00e9fices potentiels du je\u00fbne peuvent \u00eatre maintenus \u00e0 long terme. Les r\u00e9sultats obtenus pourraient ainsi contribuer ainsi au d\u00e9veloppement de traitements personnalis\u00e9s pour cette maladie complexe.<\/p>\n\n\n

    <\/div>\n\n\n

    \nPrincipaux objectifs du projet<\/strong><\/h2>\n\n\n
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    \nUn traitement efficace<\/strong><\/h3>\n\n\n\n

    Fournir un traitement efficace aux patients pour lesquels il n’existe actuellement aucune alternative th\u00e9rapeutique.<\/p>\n<\/div>\n\n\n\n

    \n

    \nComprendre les m\u00e9canismes biologiques<\/strong><\/h3>\n\n\n\n

    \u00c9valuer les changements physiologiques induits par la restriction calorique et leur impact sur les m\u00e9canismes pathologiques sous-jacents.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

    \n
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    \nComposition et fonction du microbiote intestinal<\/strong> <\/h3>\n\n\n\n

    \u00c9tudier les changements au niveau du microbiote intestinal et leurs effets sur le m\u00e9tabolisme et le syst\u00e8me immunitaire ainsi que sur les performances cognitives via l’axe intestin-cerveau.<\/p>\n<\/div>\n\n\n\n

    \n

    \nSympt\u00f4mes physiologiques et psychologiques<\/strong><\/h3>\n\n\n\n

    \u00c9valuer l\u2019am\u00e9lioration du bien-\u00eatre physique et psychologique per\u00e7u par les patients au travers de questionnaires, d\u2019entretiens et d\u2019\u00e9valuations cliniques.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

    \n
    \n
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    \n \u201f<\/span>\n Cette \u00e9tude examine les effets possibles du je\u00fbne sur les sympt\u00f4mes du COVID long et vise \u00e0 d\u00e9terminer s\u2019il peut am\u00e9liorer la qualit\u00e9 de vie des patients<\/em>\u201d\n<\/blockquote>\n
    \n
    \n \n\"Assist.\n <\/figure>\n<\/div>\n
    \n

    Assist. Prof Jochen SCHNEIDER<\/p>\n

    Assistant professor \/ Senior research scientist, Medical Translational Research group<\/p>\n

    \n \n \n Voir le profil<\/span>\n <\/span>\n <\/use><\/svg> <\/a>\n<\/div>\n<\/div>\n <\/figure>\n <\/div>\n<\/section>\n\n
    <\/div>\n\n\n\n
    <\/div><\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"

    Le projet vise \u00e0 fournir une option de traitement efficace pour les patients actuellement d\u00e9pourvus d’alternatives th\u00e9rapeutiques pour le traitement du syndrome de Long Covid en \u00e9tudiant les effets d’un r\u00e9gime de restriction calorique.<\/p>\n","protected":false},"author":63,"featured_media":979,"parent":0,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"rpp_rp_identifier":"973","rpp_taxonomies_in_sync":true},"research-project-status":[595],"research-project-type":[597,596],"field-of-interest":[289],"organisation":[344,525,543],"authorship":[63],"acf":[],"yoast_head":"\nFastCoV : une \u00e9tude sur les b\u00e9n\u00e9fices potentiels du je\u00fbne pour le traitement du COVID long - 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