{"id":1012,"date":"2024-07-09T08:05:00","date_gmt":"2024-07-09T06:05:00","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-fr\/?post_type=research-projects&#038;p=1012"},"modified":"2024-07-11T07:36:51","modified_gmt":"2024-07-11T05:36:51","slug":"contexte","status":"publish","type":"research-projects","link":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/","title":{"rendered":"Contexte"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><!-- SecondaryNavigationMirror --><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"3fe4c8c0-906a-43c2-9972-2a92c3665e52\">\n    <nav id=\"secondary-navigation\" role=\"navigation\" aria-label=\"Secondary menu\" class=\"secondary-nav\">\n        <button class=\"secondary-nav__button btn btn-solid--primary w-full\" aria-expanded=\"false\" aria-controls=\"secondary-navigation__list\" title=\"The selected page is Accueil\" type=\"button\">\n            <span class=\"btn__name mr-auto\">Accueil<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Accueil<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Contexte<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/protocole-de-letude\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Protocole de l&rsquo;\u00e9tude<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/partenaires\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Partenaires<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contact\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Contact<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<!-- end SecondaryNavigationMirror -->\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n\n<p>Peu apr\u00e8s le d\u00e9but de la pand\u00e9mie, il est devenu \u00e9vident que certaines personnes pr\u00e9sentaient des sympt\u00f4mes persistants au-del\u00e0 de la phase aigu\u00eb de l&rsquo;infection initiale. C\u2019est ce qu\u2019on appelle d\u00e9sormais le syndrome post-COVID ou COVID long. Ce syndrome regroupe une s\u00e9rie de sympt\u00f4mes qui persistent plusieurs semaines ou mois apr\u00e8s l&rsquo;infection initiale. Les sympt\u00f4mes les plus courants sont la fatigue, les difficult\u00e9s cognitives (aussi appel\u00e9es brouillard c\u00e9r\u00e9bral) et des douleurs articulaires et thoraciques.<\/p>\n\n\n\n<p>Sur cette page, vous trouverez de plus amples informations sur le COVID long, son impact sur la sant\u00e9 et la soci\u00e9t\u00e9, les approches th\u00e9rapeutiques actuelles et l\u2019exp\u00e9rience acquise par l\u2019\u00e9quipe de l\u2019\u00e9tude FastCoV dans le cadre d\u2019essais cliniques li\u00e9s \u00e0 l\u2019alimentation.<\/p>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n\n<div class=\"wp-block-unilux-blocks-accordion accordion accordion--theme accordion-standard\" data-reference=\"dd3d6f8c-eda2-41cc-a056-97b0b437a2ec\" data-accordion-type=\"standard\"><div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-2b4490e1-aafe-41d7-bdd1-0d623d66082d\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-2b4490e1-aafe-41d7-bdd1-0d623d66082d\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-2b4490e1-aafe-41d7-bdd1-0d623d66082d\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Le COVID long et son impact sur la sant\u00e9 et la soci\u00e9t\u00e9<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-2b4490e1-aafe-41d7-bdd1-0d623d66082d\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-2b4490e1-aafe-41d7-bdd1-0d623d66082d\"\n        data-bs-parent=\"[data-reference=&quot;dd3d6f8c-eda2-41cc-a056-97b0b437a2ec&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p>Le COVID long est une complication aigu\u00eb qui survient dans environ 10&nbsp;% des cas apr\u00e8s une infection par le SARS-CoV-2. L&rsquo;Organisation mondiale de la sant\u00e9 (OMS) d\u00e9finit le COVID long comme un ensemble de sympt\u00f4mes apparaissant au moins trois mois apr\u00e8s l&rsquo;infection primaire, persistant pendant au moins deux mois et ne pouvant \u00eatre attribu\u00e9s \u00e0 aucun autre diagnostic.<\/p>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n\n<p>La dur\u00e9e, l\u2019intensit\u00e9 et la gravit\u00e9 des sympt\u00f4mes sont tr\u00e8s variables. Ils comprennent fatigue, difficult\u00e9s respiratoires, douleurs, d\u00e9pression, anxi\u00e9t\u00e9 et troubles cognitifs, souvent appel\u00e9s \u00ab brouillard c\u00e9r\u00e9bral \u00bb. Ces sympt\u00f4mes ont souvent un impact sur les activit\u00e9s quotidiennes, les revenus et la qualit\u00e9 de vie. Les causes sous-jacentes du COVID long font encore l\u2019objet de recherches.<\/p>\n\n\n\n<p>Les hypoth\u00e8ses actuelles se concentrent sur :<\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Un dysfonctionnement de la r\u00e9ponse immunitaire et inflammatoire<\/li>\n\n\n\n<li class=\"ulux-list-item\">Des dommages au niveau des vaisseaux sanguins<\/li>\n\n\n\n<li class=\"ulux-list-item\">Une perturbation du m\u00e9tabolisme cellulaire<\/li>\n\n\n\n<li class=\"ulux-list-item\">Une perturbation du syst\u00e8me digestif et de son microbiote<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"Illustration des effets du COVID long\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2024\/07\/FR-LongCoV-illustration-2.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2024\/07\/FR-LongCoV-illustration-2-190x300.png 190w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2024\/07\/FR-LongCoV-illustration-2-649x1024.png 649w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2024\/07\/FR-LongCoV-illustration-2-768x1211.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2024\/07\/FR-LongCoV-illustration-2-974x1536.png 974w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2024\/07\/FR-LongCoV-illustration-2.png 1075w\"\n                style=\"object-position: 14.00% 37.00%; font-family: &quot;object-fit: cover; object-position: 14.00% 37.00%;&quot;; aspect-ratio: 2\/3; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/div>\n<\/div>\n\n<p>Les scientifiques pensent que l&rsquo;infection initiale d\u00e9clenche une r\u00e9ponse immunitaire qui, dans le cadre d\u2019un m\u00e9canisme de d\u00e9fense normal, entra\u00eene une inflammation. Dans certains cas, cette r\u00e9ponse immunitaire pourrait \u00eatre excessive ou mal r\u00e9gul\u00e9e, conduisant \u00e0 une inflammation prolong\u00e9e et \u00e0 des dommages au niveau de diff\u00e9rents organes. Ce processus existe dans d&rsquo;autres maladies chroniques telles que la polyarthrite rhumato\u00efde, le diab\u00e8te et les maladies neurod\u00e9g\u00e9n\u00e9ratives.<\/p>\n\n<p>Actuellement, plus de 65 millions de personnes dans le monde sont touch\u00e9es par le COVID long, la plupart des patients \u00e9tant \u00e2g\u00e9s de 36 \u00e0 50 ans. Dans la majorit\u00e9 des cas, les personnes ne sont pas hospitalis\u00e9es et souffrent de sympt\u00f4mes qui affectent leur sant\u00e9 et leur vie priv\u00e9e. En outre, le COVID long a des r\u00e9percussions sur la soci\u00e9t\u00e9 car de nombreux patients doivent r\u00e9duire leur temps de travail ou quitter leur emploi. Cela a des cons\u00e9quences socio-\u00e9conomiques avec notamment une augmentation du taux d&rsquo;absent\u00e9isme, une baisse de la productivit\u00e9 et une augmentation de l\u2019isolement social et de la d\u00e9tresse psychologique.<\/p>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-4cd0a760-95c4-4e6a-af7f-263510623918\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-4cd0a760-95c4-4e6a-af7f-263510623918\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-4cd0a760-95c4-4e6a-af7f-263510623918\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Les approches th\u00e9rapeutiques actuelles<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-4cd0a760-95c4-4e6a-af7f-263510623918\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-4cd0a760-95c4-4e6a-af7f-263510623918\"\n        data-bs-parent=\"[data-reference=&quot;dd3d6f8c-eda2-41cc-a056-97b0b437a2ec&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<p>Jusqu&rsquo;\u00e0 pr\u00e9sent, la prise en charge des patients passe par des plans de traitement personnalis\u00e9s, adapt\u00e9s aux sympt\u00f4mes de chacun et visant \u00e0 am\u00e9liorer autant que possible leur qualit\u00e9 de vie. Ces traitements symptomatiques ne s\u2019attaquent toutefois pas aux causes de la maladie, qui sont par ailleurs encore mal connues. Diff\u00e9rents traitements anti-inflammatoires, antiviraux ou immunomodulateurs sont en cours de d\u00e9veloppement et semblent prometteurs mais leur efficacit\u00e9 n&rsquo;a pas encore \u00e9t\u00e9 d\u00e9montr\u00e9e. Des travaux de recherche sont donc n\u00e9cessaires pour mieux comprendre la maladie et d\u00e9velopper des solutions th\u00e9rapeutiques alternatives.<\/p>\n\n<p>Des \u00e9tudes r\u00e9centes indiquent que la restriction calorique et le je\u00fbne th\u00e9rapeutique peuvent limiter les processus inflammatoires potentiellement impliqu\u00e9s dans le COVID long. Le je\u00fbne accompagn\u00e9 m\u00e9dicalement a en effet des effets b\u00e9n\u00e9fiques connus dans le cas d&rsquo;autres syndromes inflammatoires et favorise la diversit\u00e9 microbienne dans l\u2019intestin. Une \u00e9tude a par exemple montr\u00e9 que 13 sur 14 patients souffrant de maladies inflammatoires chroniques de l\u2019intestin qui je\u00fbnaient sous suivi m\u00e9dical ont vu leurs sympt\u00f4mes s&rsquo;am\u00e9liorer.<\/p>\n\n<p>Dans le cas du COVID long, le je\u00fbne pourrait donc permettre de moduler les interactions complexes entre la r\u00e9ponse immunitaire, le m\u00e9tabolisme et le microbiote intestinal. Cependant, les \u00e9tudes cliniques sur le sujet sont compliqu\u00e9es \u00e0 mettre en place de par le manque de protocoles de je\u00fbne standardis\u00e9s. De plus, \u00e9valuer de fa\u00e7on objective le respect du protocole par les participants reste difficile, ce qui peut compromettre la validit\u00e9 et la reproductibilit\u00e9 des r\u00e9sultats obtenus. Le projet FastCov vise \u00e0 combler ces lacunes, notamment gr\u00e2ce \u00e0 une phase pilote pour \u00e9valuer la faisabilit\u00e9.<\/p>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-5a47f1ba-92de-41c8-b36d-e913265799c1\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-5a47f1ba-92de-41c8-b36d-e913265799c1\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-5a47f1ba-92de-41c8-b36d-e913265799c1\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Une \u00e9quipe clinique exp\u00e9riment\u00e9e<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-5a47f1ba-92de-41c8-b36d-e913265799c1\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-5a47f1ba-92de-41c8-b36d-e913265799c1\"\n        data-bs-parent=\"[data-reference=&quot;dd3d6f8c-eda2-41cc-a056-97b0b437a2ec&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<p>L&rsquo;\u00e9quipe de l&rsquo;\u00e9tude FastCov est compos\u00e9e de chercheurs de diff\u00e9rentes <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/partenaires\/\">institutions luxembourgeoises et allemandes<\/a>. Ensemble, ils disposent d&rsquo;une large exp\u00e9rience portant notamment sur les effets de l&rsquo;alimentation sur la sant\u00e9.<\/p>\n\n<p>Les chercheurs du <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/\">Luxembourg Centre for Systems Biomedicine<\/a> (LCSB) de l&rsquo;Universit\u00e9 du Luxembourg ont par exemple r\u00e9cemment \u00e9tudi\u00e9 l&rsquo;influence du r\u00e9gime alimentaire sur les fonctions cognitives des personnes atteintes de maladies neurod\u00e9g\u00e9n\u00e9ratives. Ils ont cherch\u00e9 \u00e0 savoir si des choix di\u00e9t\u00e9tiques cibl\u00e9s pouvaient avoir un effet b\u00e9n\u00e9fique. Avec leurs coll\u00e8gues du <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-departments\/department-of-life-sciences-and-medicine\/\">Department of Life Sciences and Medicine<\/a>, ils ont aussi d\u00e9velopp\u00e9 le protocole d&rsquo;ExpoBiome, une \u00e9tude clinique multicentrique qui examine les liens entre le microbiote intestinal, le je\u00fbne et le statut immunitaire chez les patients atteints de polyarthrite rhumato\u00efde et de la maladie de Parkinson.<\/p>\n\n<p>L&rsquo;\u00e9quipe de&nbsp;l\u2019h\u00f4pital universitaire de la <a href=\"https:\/\/www.charite.de\/en\/\" target=\"_blank\" rel=\"noreferrer noopener\">Charit\u00e9 \u00e0 Berlin<\/a> a contribu\u00e9 \u00e0 l&rsquo;\u00e9tude NutriFast, qui examine l&rsquo;efficacit\u00e9 du je\u00fbne th\u00e9rapeutique et de l&rsquo;alimentation v\u00e9g\u00e9tale chez les personnes atteintes de polyarthrite rhumato\u00efde. En analysant des gouttes de sang s\u00e9ch\u00e9, les chercheurs ont pu identifier plusieurs m\u00e9tabolites qui sont surexprim\u00e9s pendant le je\u00fbne et mettre en \u00e9vidence des voies sp\u00e9cifiques impliqu\u00e9es dans la r\u00e9ponse \u00e0 la restriction calorique.<\/p>\n\n<p>En tant que participant \u00e0 l&rsquo;\u00e9tude FastCoV, vous serez accompagn\u00e9 par cette \u00e9quipe exp\u00e9riment\u00e9e tout au long de l&rsquo;\u00e9tude, de la premi\u00e8re s\u00e9ance d&rsquo;information jusqu&rsquo;au retour progressif \u00e0 une alimentation normale, en passant par des rendez-vous r\u00e9guliers pendant la phase de je\u00fbne,<\/p>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-635076d9-cbf4-4a4b-9fc4-96f0b9e49d25\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-635076d9-cbf4-4a4b-9fc4-96f0b9e49d25\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-635076d9-cbf4-4a4b-9fc4-96f0b9e49d25\"\n        >\n            <span class=\"accordion__title\">\n                                <strong>Une s\u00e9lection d\u2019articles scientifiques pour en savoir plus<\/strong>            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-635076d9-cbf4-4a4b-9fc4-96f0b9e49d25\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-635076d9-cbf4-4a4b-9fc4-96f0b9e49d25\"\n        data-bs-parent=\"[data-reference=&quot;dd3d6f8c-eda2-41cc-a056-97b0b437a2ec&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<p>1. A. V. Raveendran, R. Jayadevan, and S. Sashidharan, \u201cLong COVID: An overview,\u201d&nbsp;<em>Diabetes Metab. Syndr.<\/em>, vol. 15, no. 3, pp. 869\u2013875, 2021, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33892403\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.dsx.2021.04.007<\/a>.<\/p>\n\n<p id=\"references-10\">2. D. L. Sykes, L. Holdsworth, N. Jawad, P. Gunasekera, A. H. Morice, and M. G. Crooks, \u201cPost-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?,\u201d&nbsp;<em>Lung<\/em>, vol. 199, no. 2, pp. 113\u2013119, Apr. 2021, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33569660\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1007\/s00408-021-00423-z<\/a>.<\/p>\n\n<p>3. L. Kohn&nbsp;<em>et al.<\/em>, \u201cLong COVID and return to work: a qualitative study,\u201d&nbsp;<em>Occup. Med. Oxf. Engl.<\/em>, vol. 74, no. 1, pp. 29\u201336, Feb. 2024, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36480262\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1093\/occmed\/kqac119<\/a>.<\/p>\n\n<p>4. M. S. Durstenfeld&nbsp;<em>et al.<\/em>, \u201cAssociation of nirmatrelvir for acute SARS-CoV-2 infection with subsequent Long COVID symptoms in an observational cohort study,\u201d&nbsp;<em>J. Med. Virol.<\/em>, vol. 96, no. 1, p. e29333, 2024, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38175151\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1002\/jmv.29333<\/a>.<\/p>\n\n<p>5. X. Y. Loke, S. A. M. Imran, G. J. Tye, W. S. Wan Kamarul Zaman, and F. Nordin, \u201cImmunomodulation and Regenerative Capacity of MSCs for Long-COVID,\u201d&nbsp;<em>Int. J. Mol. Sci.<\/em>, vol. 22, no. 22, Art. no. 22, Jan. 2021, doi: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8625432\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.3390\/ijms222212421<\/a>.<\/p>\n\n<p>6. N. Nagata&nbsp;<em>et al.<\/em>, \u201cHuman Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications,\u201d&nbsp;<em>Gastroenterology<\/em>, vol. 164, no. 2, pp. 272\u2013288, Feb. 2023, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36155191\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1053\/j.gastro.2022.09.024<\/a>.<\/p>\n\n<p>7. F. Grundler, R. Mesnage, A. Cerrada, and F. Wilhelmi de Toledo, \u201cImprovements during long-term fasting in patients with long COVID \u2013 a case series and literature review,\u201d&nbsp;<em>Front. Nutr.<\/em>, vol. 10, p. 1195270, Nov. 2023, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38024352\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.3389\/fnut.2023.1195270<\/a>.<\/p>\n\n<p>8. B. Hansen, K. Roomp, H. Ebid and J.-G. Schneider. \u00ab\u00a0Perspective: The Impact of Fasting and Caloric Restriction on Neurodegenerative Diseases in Human,\u00a0\u00bb Adv Nutr. 2024 Apr;15(4):100197. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38432589\/\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.advnut.2024.100197<\/a>.<\/p>\n\n<p>9. B. Hansen&nbsp;<em>et al.<\/em>, \u201cProtocol for a multicentre cross-sectional, longitudinal ambulatory clinical trial in rheumatoid arthritis and Parkinson\u2019s disease patients analysing the relation between the gut microbiome, fasting and immune status in Germany (ExpoBiome),\u201d&nbsp;<em>BMJ Open<\/em>, vol. 13, no. 8, p. e071380, Aug. 2023, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37597865\/\">10.1136\/bmjopen-2022-071380<\/a>.<\/p>\n\n<p>10.&nbsp;A. M. Hartmann&nbsp;<em>et al.<\/em>, \u201cPost Hoc Analysis of a Randomized Controlled Trial on Fasting and Plant-Based Diet in Rheumatoid Arthritis (NutriFast): Nutritional Supply and Impact on Dietary Behavior,\u201d&nbsp;<em>Nutrients<\/em>, vol. 15, no. 4, Art. no. 4, Jan. 2023, doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36839208\/\">10.3390\/nu15040851<\/a>.<\/p>\n        <\/div>\n    <\/div>\n<\/div><\/div>\n<\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":63,"featured_media":0,"parent":975,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"rpp_rp_identifier":"973","rpp_taxonomies_in_sync":true},"research-project-status":[595],"research-project-type":[597,596],"field-of-interest":[289],"organisation":[344,525,543],"authorship":[63],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Contexte - LCSB - Universit\u00e9 du Luxembourg I Uni.lu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Contexte\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/\" \/>\n<meta property=\"og:site_name\" content=\"LCSB FR\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-11T05:36:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/\",\"name\":\"Contexte - LCSB - Universit\u00e9 du Luxembourg I Uni.lu\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#website\"},\"datePublished\":\"2024-07-09T06:05:00+00:00\",\"dateModified\":\"2024-07-11T05:36:51+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.uni.lu\/fr\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Luxembourg Centre for Systems Biomedicine (LCSB)\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research Projects Pages\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"FastCoV : une \u00e9tude sur les b\u00e9n\u00e9fices potentiels du je\u00fbne pour le traitement du COVID long\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Contexte\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#website\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/\",\"name\":\"LCSB\",\"description\":\"Luxembourg Centre for Systems Biomedicine I Uni.lu\",\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#organization\"},\"alternateName\":\"Luxembourg Centre for Systems Biomedicine I Universit\u00e9 du Luxembourg\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.uni.lu\/lcsb-fr\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#organization\",\"name\":\"LCSB - Universit\u00e9 du Luxembourg I Uni.lu\",\"alternateName\":\"Luxembourg Centre for Systems Biomedicine\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\",\"width\":2560,\"height\":2560,\"caption\":\"LCSB - Universit\u00e9 du Luxembourg I Uni.lu\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.linkedin.com\/showcase\/lcsb-university-of-luxembourg\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Contexte - LCSB - Universit\u00e9 du Luxembourg I Uni.lu","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/","og_locale":"fr_FR","og_type":"article","og_title":"Contexte","og_url":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/","og_site_name":"LCSB FR","article_modified_time":"2024-07-11T05:36:51+00:00","og_image":[{"width":2560,"height":2560,"url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/","url":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/","name":"Contexte - LCSB - Universit\u00e9 du Luxembourg I Uni.lu","isPartOf":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#website"},"datePublished":"2024-07-09T06:05:00+00:00","dateModified":"2024-07-11T05:36:51+00:00","breadcrumb":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/contexte\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.uni.lu\/fr"},{"@type":"ListItem","position":2,"name":"Luxembourg Centre for Systems Biomedicine (LCSB)","item":"https:\/\/www.uni.lu\/lcsb-fr\/"},{"@type":"ListItem","position":3,"name":"Research Projects Pages","item":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/"},{"@type":"ListItem","position":4,"name":"FastCoV : une \u00e9tude sur les b\u00e9n\u00e9fices potentiels du je\u00fbne pour le traitement du COVID long","item":"https:\/\/www.uni.lu\/lcsb-fr\/research-projects\/fastcov\/"},{"@type":"ListItem","position":5,"name":"Contexte"}]},{"@type":"WebSite","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#website","url":"https:\/\/www.uni.lu\/lcsb-fr\/","name":"LCSB","description":"Luxembourg Centre for Systems Biomedicine I Uni.lu","publisher":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#organization"},"alternateName":"Luxembourg Centre for Systems Biomedicine I Universit\u00e9 du Luxembourg","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.uni.lu\/lcsb-fr\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#organization","name":"LCSB - Universit\u00e9 du Luxembourg I Uni.lu","alternateName":"Luxembourg Centre for Systems Biomedicine","url":"https:\/\/www.uni.lu\/lcsb-fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","width":2560,"height":2560,"caption":"LCSB - Universit\u00e9 du Luxembourg I Uni.lu"},"image":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/showcase\/lcsb-university-of-luxembourg"]}]}},"_links":{"self":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/research-projects\/1012"}],"collection":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/research-projects"}],"about":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/types\/research-projects"}],"author":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/users\/63"}],"version-history":[{"count":2,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/research-projects\/1012\/revisions"}],"predecessor-version":[{"id":1034,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/research-projects\/1012\/revisions\/1034"}],"up":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/research-projects\/975"}],"wp:authorship":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/users\/63"}],"wp:attachment":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/media?parent=1012"}],"wp:term":[{"taxonomy":"research-project-status","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/research-project-status?post=1012"},{"taxonomy":"research-project-type","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/research-project-type?post=1012"},{"taxonomy":"field-of-interest","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/field-of-interest?post=1012"},{"taxonomy":"organisation","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/organisation?post=1012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}