{"id":1089,"date":"2024-07-22T16:43:09","date_gmt":"2024-07-22T14:43:09","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-fr\/?page_id=1089"},"modified":"2024-07-31T14:37:03","modified_gmt":"2024-07-31T12:37:03","slug":"differences-sexes-alzheimer","status":"publish","type":"page","link":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/","title":{"rendered":"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><!-- SecondaryNavigationMirror --><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"079cacee-a280-4f42-8b0f-7a37a67d3516\">\n    <nav id=\"secondary-navigation\" role=\"navigation\" aria-label=\"Secondary menu\" class=\"secondary-nav\">\n        <button class=\"secondary-nav__button btn btn-solid--primary w-full\" aria-expanded=\"false\" aria-controls=\"secondary-navigation__list\" title=\"The selected page is \u00c0 propos\" type=\"button\">\n            <span class=\"btn__name mr-auto\">\u00c0 propos<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">\u00c0 propos<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/quand-pourquoi\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Quand et pourquoi <\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/comment-protegeons-nous-les-animaux\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Bien-\u00eatre<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/le-droit-luxembourgeois\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Droit luxembourgeois <\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/les-3r\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Les 3R<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/installations\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Installations<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/faits-chiffres\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Faits et chiffres<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Exemples de projets<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/formation\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Formation<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<!-- end SecondaryNavigationMirror --><\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"differences-entre-les-sexes-dans-la-maladie-dalzheimer\"\n    >\nDiff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer<\/h1>\n\n\n\n<p>Le vieillissement est consid\u00e9r\u00e9 comme le principal facteur de risque pour la maladie d\u2019Alzheimer. Cependant, cette maladie neurod\u00e9g\u00e9n\u00e9rative affecte beaucoup plus souvent les femmes que les hommes, m\u00eame quand on tient compte de l\u2019esp\u00e9rance de vie plus longue. Les \u00e9tudes portant sur le vieillissement du cerveau humain r\u00e9v\u00e8lent \u00e9galement une diff\u00e9rence dans l\u2019activit\u00e9 de certains g\u00e8nes entre les hommes et les femmes. Certains de ces g\u00e8nes sont fonctionnellement li\u00e9s au m\u00e9canisme mol\u00e9culaire de la maladie d\u2019Alzheimer. Enrico Glaab, responsable du groupe Biomedical Data Science du LCSB, cherche \u00e0 comprendre comment les changements biomol\u00e9culaires sp\u00e9cifiques au sexe survenant dans le cerveau humain contribuent aux diff\u00e9rences observ\u00e9es entre les hommes et les femmes dans la maladie d\u2019Alzheimer.<\/p>\n\n\n\n<p>Pour r\u00e9pondre \u00e0 cette question, Glaab a r\u00e9alis\u00e9 une analyse statistique d\u2019ensembles de donn\u00e9es relatives \u00e0 la transcription de l\u2019ADN provenant de cerveaux post-mortem de patients atteints de la maladie d\u2019Alzheimer et de sujets sains du m\u00eame \u00e2ge, ainsi que d\u2019individus sains d\u2019\u00e2ges diff\u00e9rents. L\u2019objectif \u00e9tait d\u2019identifier des g\u00e8nes dont l\u2019activit\u00e9 diff\u00e8re significativement entre les hommes et les femmes au cours du vieillissement et qui sont alt\u00e9r\u00e9s chez les patients atteints de la maladie d\u2019Alzheimer. Glaab a ainsi identifi\u00e9 un g\u00e8ne, la peptidase 9 sp\u00e9cifique \u00e0 l\u2019ubiquitine (USP9), qui r\u00e9pondait \u00e0 ces crit\u00e8res. L\u2019USP9 r\u00e9gule la prot\u00e9ine tau associ\u00e9e aux microtubules (MAPT), qui est associ\u00e9e \u00e0 la maladie d\u2019Alzheimer. Les profils d\u2019expression du g\u00e8ne USP9 et de la prot\u00e9ine tau sont fortement corr\u00e9l\u00e9s.<\/p>\n\n\n\n<p>Afin d\u2019\u00e9tudier les liens fonctionnels entre le g\u00e8ne USP9 et la prot\u00e9ine tau et leur r\u00f4le dans la maladie d\u2019Alzheimer, Glaab collabore avec des coll\u00e8gues du groupe Experimental Neurobiology et du groupe Chemical Biology du LCSB. Les chercheurs examinent le r\u00f4le jou\u00e9 par le g\u00e8ne USP9, d\u2019abord dans des cultures cellulaires, puis chez des mod\u00e8les de poissons-z\u00e8bres et de souris. L\u2019analyse informatique a permis aux chercheurs de r\u00e9duire le nombre des g\u00e8nes candidats \u00e0 USP9 uniquement, ce qui a consid\u00e9rablement r\u00e9duit le nombre d\u2019animaux n\u00e9cessaires pour l\u2019\u00e9tude. Une fois que les travaux sur les cultures cellulaires et le poisson-z\u00e8bre auront d\u00e9montr\u00e9 que l\u2019inactivation du g\u00e8ne USP9 r\u00e9duit l\u2019expression de la prot\u00e9ine tau, les chercheurs pourront \u00e9tudier l\u2019activit\u00e9 de USP9 dans un nouveau mod\u00e8le murin de la maladie d\u2019Alzheimer. \u00c9tant donn\u00e9 que les changements dans l\u2019expression de la prot\u00e9ine tau sont consid\u00e9r\u00e9s comme une caract\u00e9ristique mol\u00e9culaire de la maladie d\u2019Alzheimer et d\u2019autres maladies associ\u00e9es, les r\u00e9gulateurs cl\u00e9s potentiels de l\u2019activit\u00e9 de cette prot\u00e9ine, comme le g\u00e8ne USP9, pourraient faire l\u2019objet d\u2019\u00e9tudes plus approfondies en tant que cible pour de nouvelles th\u00e9rapies.<\/p>\n\n\n\n<p>Les travaux de Prof. Glaab illustrent comment les chercheurs du LCSB choisissent la m\u00e9thode de recherche la plus appropri\u00e9e pour r\u00e9pondre \u00e0 une question scientifique donn\u00e9e. En passant d\u2019abord d\u2019ensembles de donn\u00e9es humaines \u00e0 des mod\u00e8les informatiques et des cultures cellulaires, les chercheurs ont pu formuler des hypoth\u00e8ses solides, et ne recourir \u00e0 l&rsquo;exp\u00e9rimentation animale que lorsque aucune autre m\u00e9thode de recherche ne permet de r\u00e9pondre \u00e0 la question scientifique.<\/p>\n\n\n\n<p>La proposition de projet de Glaab a remport\u00e9 le Global Neuro Discovery Challenge de la fondation Geoffrey Beene en\u00a02013.<\/p>\n<\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":39,"featured_media":0,"parent":1078,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"field-of-interest":[289],"organisation":[526,525],"authorship":[39,56],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer - LCSB - Universit\u00e9 du Luxembourg I Uni.lu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/\" \/>\n<meta property=\"og:site_name\" content=\"LCSB FR\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-31T12:37:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/\",\"name\":\"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer - LCSB - Universit\u00e9 du Luxembourg I Uni.lu\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#website\"},\"datePublished\":\"2024-07-22T14:43:09+00:00\",\"dateModified\":\"2024-07-31T12:37:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.uni.lu\/fr\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Luxembourg Centre for Systems Biomedicine (LCSB)\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Recherche\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Recherche animale\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Exemples de projets de recherche\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/\"},{\"@type\":\"ListItem\",\"position\":6,\"name\":\"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#website\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/\",\"name\":\"LCSB\",\"description\":\"Luxembourg Centre for Systems Biomedicine I Uni.lu\",\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#organization\"},\"alternateName\":\"Luxembourg Centre for Systems Biomedicine I Universit\u00e9 du Luxembourg\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.uni.lu\/lcsb-fr\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#organization\",\"name\":\"LCSB - Universit\u00e9 du Luxembourg I Uni.lu\",\"alternateName\":\"Luxembourg Centre for Systems Biomedicine\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\",\"width\":2560,\"height\":2560,\"caption\":\"LCSB - Universit\u00e9 du Luxembourg I Uni.lu\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.linkedin.com\/showcase\/lcsb-university-of-luxembourg\"],\"description\":\"Luxembourg Centre for Systems Biomedicine I Uni.lu\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer - LCSB - Universit\u00e9 du Luxembourg I Uni.lu","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/","og_locale":"fr_FR","og_type":"article","og_title":"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer","og_url":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/","og_site_name":"LCSB FR","article_modified_time":"2024-07-31T12:37:03+00:00","og_image":[{"width":2560,"height":2560,"url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/","url":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/","name":"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer - LCSB - Universit\u00e9 du Luxembourg I Uni.lu","isPartOf":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#website"},"datePublished":"2024-07-22T14:43:09+00:00","dateModified":"2024-07-31T12:37:03+00:00","breadcrumb":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/differences-sexes-alzheimer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.uni.lu\/fr"},{"@type":"ListItem","position":2,"name":"Luxembourg Centre for Systems Biomedicine (LCSB)","item":"https:\/\/www.uni.lu\/lcsb-fr\/"},{"@type":"ListItem","position":3,"name":"Recherche","item":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/"},{"@type":"ListItem","position":4,"name":"Recherche animale","item":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/"},{"@type":"ListItem","position":5,"name":"Exemples de projets de recherche","item":"https:\/\/www.uni.lu\/lcsb-fr\/recherche\/recherche-animale\/exemples-projets-recherche\/"},{"@type":"ListItem","position":6,"name":"Diff\u00e9rences entre les sexes dans la maladie d\u2019Alzheimer"}]},{"@type":"WebSite","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#website","url":"https:\/\/www.uni.lu\/lcsb-fr\/","name":"LCSB","description":"Luxembourg Centre for Systems Biomedicine I Uni.lu","publisher":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#organization"},"alternateName":"Luxembourg Centre for Systems Biomedicine I Universit\u00e9 du Luxembourg","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.uni.lu\/lcsb-fr\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#organization","name":"LCSB - Universit\u00e9 du Luxembourg I Uni.lu","alternateName":"Luxembourg Centre for Systems Biomedicine","url":"https:\/\/www.uni.lu\/lcsb-fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","width":2560,"height":2560,"caption":"LCSB - Universit\u00e9 du Luxembourg I Uni.lu"},"image":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/showcase\/lcsb-university-of-luxembourg"],"description":"Luxembourg Centre for Systems Biomedicine I Uni.lu"}]}},"ticketed":false,"_links":{"self":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/pages\/1089"}],"collection":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/users\/39"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/comments?post=1089"}],"version-history":[{"count":3,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/pages\/1089\/revisions"}],"predecessor-version":[{"id":1201,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/pages\/1089\/revisions\/1201"}],"up":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/pages\/1078"}],"wp:authorship":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/users\/39"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/users\/56"}],"wp:attachment":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/media?parent=1089"}],"wp:term":[{"taxonomy":"field-of-interest","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/field-of-interest?post=1089"},{"taxonomy":"organisation","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/organisation?post=1089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}