{"id":986,"date":"2024-07-03T12:45:57","date_gmt":"2024-07-03T10:45:57","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-fr\/?post_type=news&p=986"},"modified":"2024-07-03T12:59:05","modified_gmt":"2024-07-03T10:59:05","slug":"ncer-pd-luxembourg-rejoint-ppmi","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/lcsb-fr\/news\/ncer-pd-luxembourg-rejoint-ppmi\/","title":{"rendered":"L’excellence de la recherche luxembourgeoise sur la maladie de Parkinson se mondialise"},"content":{"rendered":"\n
\n

\nLe NCER-PD rejoint la prestigieuse initiative \u00ab\u00a0Parkinson\u2019s Progression Markers\u00a0\u00bb de la Fondation Michael J. Fox<\/strong><\/strong><\/h2>\n\n\n\n

Le Luxembourg Institute of Health (LIH)<\/a>, le Centre Hospitalier de Luxembourg (CHL)<\/a>, l<\/em>e Luxembourg Centre for Systems Biomedicine (LCSB) de l\u2019Universit\u00e9, le Laboratoire National de Sant\u00e9 (LNS)<\/a> et Les H\u00f4pitaux Robert Schuman (HRS)<\/a> ont le plaisir d’annoncer que le Centre national d’excellence dans la recherche sur la maladie de Parkinson (NCER-PD)<\/a> est devenu l’un des 51 sites cliniques participant \u00e0 l’Initiative sur les marqueurs de progression de la maladie de Parkinson (Parkinson\u2019s Progression Markers Initiative – PPMI<\/a>), une \u00e9tude clinique observationnelle de r\u00e9f\u00e9rence promue par la Fondation Michael J. Fox (Michael J. Fox Foundation for Parkinson\u2019s Research – MJFF).<\/p>\n\n\n\n

Lanc\u00e9e en 2010, PPMI est largement reconnue comme l’initiative la plus ambitieuse et la plus importante dans l’histoire de la recherche sur la maladie de Parkinson (MP). Elle vise \u00e0 d\u00e9velopper des marqueurs biologiques du risque, de l’apparition et de la progression de la maladie de Parkinson en \u00e9tablissant une vaste collection d’\u00e9chantillons cliniques et biologiques dans de multiples cohortes, dans le but de faire progresser la pr\u00e9vention, le diagnostic et le traitement de cette maladie neurod\u00e9g\u00e9n\u00e9rative. PPMI a r\u00e9cemment permis le d\u00e9veloppement d’un nouveau test biologique pour la maladie de Parkinson<\/a> (alpha-synuclein seed amplification assay \u2013 \u03b1Syn-SAA), qui d\u00e9montre une grande pr\u00e9cision diagnostique, diff\u00e9rencie les sous-types mol\u00e9culaires et d\u00e9tecte la maladie avant l’apparition des sympt\u00f4mes. Au cours de la prochaine phase de recherche, PPMI \u00e9largira sa population d’\u00e9tude pour inclure des individus qui n’ont pas encore d\u00e9velopp\u00e9 les sympt\u00f4mes de mouvement de la MP, mais qui peuvent \u00eatre expos\u00e9s \u00e0 un risque accru de d\u00e9velopper la maladie.<\/p>\n\n\n\n

Dans ce contexte, le NCER-PD est d\u00e9sormais l’un des 51 sites de recrutement de PPMI dans le monde et contribuera \u00e0 l\u2019\u00e9tude gr\u00e2ce \u00e0 l’expertise in\u00e9gal\u00e9e du Luxembourg dans l’\u00e9tablissement de cohortes de participants diversifi\u00e9es et profond\u00e9ment caract\u00e9ris\u00e9es. En effet, des milliers de participants au Luxembourg ont d\u00e9j\u00e0 soutenu NCER-PD, notamment dans le contexte de la cohorte initiale de 1 600 patients atteints de MP et de volontaires en bonne sant\u00e9 du Luxembourg et de la Grande R\u00e9gion, ainsi que dans le contexte de deux nouvelles cohortes comprenant des personnes pr\u00e9sentant des facteurs de risque tels que le trouble du comportement en sommeil paradoxal et des individus porteurs de mutations du g\u00e8ne GBA1, en plus des participants de l’\u00e9tude \u00ab Healthy Brain Ageing \u00bb (HeBA). <\/p>\n\n\n\n

\u00ab Bien que des progr\u00e8s aient \u00e9t\u00e9 r\u00e9alis\u00e9s en termes d’am\u00e9lioration du diagnostic de la maladie de Parkinson, nous devons encore explorer davantage le r\u00f4le d’une vari\u00e9t\u00e9 de facteurs dans la pr\u00e9diction de son apparition et de sa progression. \u00c0 cette fin, la cr\u00e9ation de cohortes d’individus pr\u00e9sentant des facteurs de risque connus est un \u00e9l\u00e9ment cl\u00e9. Nous sommes donc ravis de contribuer \u00e0 une \u00e9tude clinique internationale aussi prestigieuse gr\u00e2ce \u00e0 nos connaissances et \u00e0 notre expertise dans la mise en place de telles cohortes et dans la d\u00e9couverte et la validation de biomarqueurs<\/em> \u00bb, explique le professeur Rejko Kr\u00fcger, directeur de l\u2019unit\u00e9 de m\u00e9decine transversale translationnelle (TTM) au LIH<\/a>, chef du groupe de recherche \u00ab neurosciences translationnelles \u00bb au LCSB<\/a>, neurologue au CHL et coordinateur de NCER-PD.   <\/p>\n\n\n\n

Le consortium de NCER-PD, dirig\u00e9 par le LIH en collaboration avec le LCSB, le Centre Hospitalier de Luxembourg (CHL), les H\u00f4pitaux Robert Schuman (HRS) et le Laboratoire National de Sant\u00e9 (LNS), sera responsable du recrutement des participants locaux – y compris les personnes vivant avec la maladie et les personnes \u00e0 risque – \u00e0 la \u00ab Parkinson Research Clinic \u00bb dans le cadre du Centre luxembourgeois de recherche clinique et translationnelle<\/a> (LCTR – Fuerschungsklinik L\u00ebtzebuerg) r\u00e9cemment mis en place. Le recrutement des participants sur le site luxembourgeois de PPMI a d\u00e9but\u00e9 en avril et devrait durer jusqu’en d\u00e9cembre 2026, l’objectif \u00e9tant de recruter au moins 50 personnes. Les premiers participants luxembourgeois font actuellement l’objet d’un processus de s\u00e9lection en vue du recrutement. Il s’agit de personnes \u00e2g\u00e9es de plus de 60 ans pr\u00e9sentant des facteurs de risque tels qu’une diminution de l’odorat (hyposmie), un membre de la famille au premier degr\u00e9 atteint de la MP, des mutations g\u00e9n\u00e9tiques dans les g\u00e8nes LRRK2 et\/ou GBA, ou un diagnostic de trouble du comportement en sommeil paradoxal. Des visites de suivi suppl\u00e9mentaires seront pr\u00e9vues pour les participants inclus. <\/p>\n\n\n\n

\u00ab Nous sommes extr\u00eamement reconnaissants \u00e0 la Fondation Michael J. Fox de nous avoir donn\u00e9 l’opportunit\u00e9 de participer \u00e0 une \u00e9tude internationale aussi novatrice et nous nous r\u00e9jouissons de collaborer \u00e0 cette initiative mondiale d’excellence dans le domaine de la maladie de Parkinson. J’aimerais \u00e9galement renouveler notre gratitude \u00e0 tous les participants actuels et futurs de l’\u00e9tude pour leur aide concr\u00e8te dans la lutte permanente contre ce trouble neurod\u00e9g\u00e9n\u00e9ratif<\/em> \u00bb, ajoute le professeur Kr\u00fcger. <\/p>\n\n\n\n

\u00ab C’est en faisant appel au pouvoir de la communaut\u00e9 pour \u00e9largir notre compr\u00e9hension de la biologie de la maladie de Parkinson et \u00e0 l’exp\u00e9rience v\u00e9cue par les patients que la Fondation a permis les derni\u00e8res perc\u00e9es scientifiques<\/em> \u00bb, a d\u00e9clar\u00e9 Mark Frasier, PhD, directeur scientifique de la MJFF. \u00ab Gr\u00e2ce au soutien des patients, de leurs proches, et des responsables d’\u00e9tudes du monde entier, PPMI a transform\u00e9 tout ce que nous savons sur la fa\u00e7on dont la maladie se d\u00e9clare et \u00e9volue au fil du temps. Avec l’expansion des sites PPMI dans le monde entier, y compris nos amis des principaux instituts de recherche du Luxembourg, nous sommes pr\u00eats \u00e0 maintenir une dynamique essentielle dans l’\u00e8re de la recherche sur la maladie de Parkinson<\/em> \u00bb.<\/p>\n\n\n

\n \n

\nEn savoir plus sur le chercheur<\/h2>\n
    \n
  • \n
    \n
    \n
    \n \n\"Prof\n <\/figure>\n <\/div>\n
    \n

    Prof Rejko KR\u00dcGER<\/h3>\n

    Full professor in Neurosciences \u2013 FNR PEARL Chair<\/p>\n

    \n \n \n Voir le profil<\/span>\n <\/span>\n <\/use><\/svg> <\/a>\n<\/div>\n <\/div>\n <\/div>\n<\/div>\n<\/div><\/li><\/ul>\n\n<\/div>\n\n\n\n\n

    Photo : Shutterstock<\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":56,"featured_media":987,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[3],"news-topic":[18],"organisation":[525,551],"authorship":[56],"acf":[],"yoast_head":"\nL'excellence de la recherche luxembourgeoise sur la maladie de Parkinson se mondialise - 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