{"id":84,"date":"2019-03-07T08:28:19","date_gmt":"2019-03-07T08:28:19","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-fr\/news\/transmission-of-microbes-along-the-digestive-tract\/"},"modified":"2019-03-07T08:28:19","modified_gmt":"2019-03-07T08:28:19","slug":"transmission-of-microbes-along-the-digestive-tract","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/lcsb-fr\/news\/transmission-of-microbes-along-the-digestive-tract\/","title":{"rendered":"Transmission of microbes along the digestive tract"},"content":{"rendered":"<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><p>The gastrointestinal tract is abundantly colonised by microbes but the transmission of oral species to the intestine was considered a rare aberrant event, and a hallmark of disease. A recent study now shows that many gut microbes may in fact originate in the mouth.<\/p><p>In this study, <a href=\"https:\/\/www.fnr.lu\/international-cooperation\/embl\/\" target=\"_blank\" title=\"\" rel=\"noopener\">supported by the FNR\u2019s CORE programme<\/a>, researchers of the <a href=\"https:\/\/wwwen.uni.lu\/lcsb\/research\/eco_systems_biology\" target=\"_blank\" title=\"\" rel=\"noopener\">Eco-Systems Biology group<\/a> at the LCSB and collaborators from <a href=\"https:\/\/www.embl.de\/index.php\" target=\"_blank\" title=\"\" rel=\"noopener\">two research groups at EMBL<\/a> found that transmission to, and subsequent colonisation of, the large intestine by oral microbes is common among healthy individuals. Their results, <i>eLIFE<\/i>, establish oral-fecal transmission as an important process that shapes the gastrointestinal microbiome in health and disease.<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"even-in-healthy-people-many-oral-microbes-colonise-the-gut\"\n    >\nEven in healthy people, many oral microbes colonise the gut<\/h2>\n<p>The mouth and the gut are abundantly colonised by microbes and linked by a constant flow of food and saliva. Despite this, they host distinctly different microbiomes. The acidic stomach and antimicrobial small intestine form an oral-gut barrier which was thought to kill off the vast majority of oral microbes before they reached the gut.<\/p><p>Oral-gut transmission occurs when enough cells of an oral species survive the population bottleneck of the oral-gut barrier to establish a new colony inside the gut. This barrier failure has previously been considered rare and \u2013 when it does happen \u2013 associated with various diseases.\u00a0<\/p><p>\u201cHowever, during this study, we have identified many shared microbial strains in saliva and stool samples from several hundred people across three continents,\u201d explains Ass. Prof. Dr Paul Wilmes, head of the Eco-Systems Biology group and co-author of the study. \u201cOur research shows that the barrier between oral and gut microbiomes is weaker than expected and that oral-gut transmission is actually very common in healthy people.\u201d<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"potential-role-in-colorectal-cancer\"\n    >\nPotential role in colorectal cancer<\/h2>\n<p>Their results also highlight that there are increased levels of transmission in patients suffering from colorectal cancer or rheumatoid arthritis, suggesting oral-gut transmission of several microbes could play a role in the progression of colorectal cancer. More generally, species described as opportunistic pathogens were found to be more transferable.<\/p><p>These findings establish the mouth as a potential source of gut microbial species and demonstrate that microbes linked to colorectal cancer may originate from within the body rather than the environment. Scientists must now assess whether interventions in the oral microbial community could impact the gut microbiome and its effects on human health.<\/p><p>&#8212;<\/p><p>Reference:\u00a0 Schmidt TSB, Hayward MR, et al. Extensive Transmission of Microbes along the Gastrointestinal Tract, <i>eLife<\/i>, published online 12 February 2019. DOI:10.7554\/eLife.42693<\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>The gastrointestinal tract is abundantly colonised by microbes but the transmission of oral species to the intestine was considered a rare aberrant event, and a hallmark of disease. A recent study now shows that many gut microbes may in fact originate in the mouth.<\/p>\n","protected":false},"author":0,"featured_media":85,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[3],"news-topic":[18],"organisation":[],"authorship":[39],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Transmission of microbes along the digestive tract - LCSB - Universit\u00e9 du Luxembourg I Uni.lu<\/title>\n<meta name=\"description\" content=\"The gastrointestinal tract is abundantly colonised by microbes but the transmission of oral species to the intestine was considered a rare aberrant event, and a hallmark of disease. 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