{"id":282,"date":"2023-04-25T07:00:15","date_gmt":"2023-04-25T07:00:15","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/"},"modified":"2024-08-16T13:19:47","modified_gmt":"2024-08-16T11:19:47","slug":"differentiating-typical-and-atypical-parkinsonism-early-in-disease","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/","title":{"rendered":"Differentiating typical and atypical parkinsonism early in disease"},"content":{"rendered":"\n
\n

The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism. This aims to improve early detection and diagnosis of typical Parkinson’s disease (PD) but also atypical forms, such as multiple system atrophy (MSA) and dementia with Lewy bodies (DLB).<\/p>\n\n\n\n

The study will use detailed clinical assessments, molecular markers, and data analysis to identify specific profiles in the early stages of the three diseases. The collaborative research involving researchers from Italy, Sweden, France, Denmark, Croatia and Luxembourg is funded with 1.75 Mio EUR over three years by the European ERA PerMed scheme of the Horizon Europe initiative of the EU (Grant Agreement Number: 779282 \u2013 Project Grant Number: INTER\/PerMed22\/17045084), which aims to strengthen European collaboration and competitiveness in the field of personalised medicine.<\/p>\n\n\n

\n \n\"Deepen <\/figure>\n\n\n

\niRBD as a common indicator for different forms of parkinsonism<\/h4>\n\n\n\n

Idiopathic REM sleep behaviour disorder (iRBD) is a specific sleep disorder in which people act out their dream through uncontrolled movement and actions. It has been linked to a high risk of conversion to Parkinson\u2019s disease, multiple system atrophy, or dementia with Lewy bodies. These neurodegenerative diseases are also referred to as synucleinopathies, as they share similarities at the cellular level. Here the protein alpha-synuclein aggregates inside the nerve cell, leading to functional disturbances and premature ageing and death of the cell. While early clinical features of the diseases, such as mood changes, sleep disturbances and mild cognitive impairment, are similar, the later stages present much differently, with significant therapeutic and prognostic consequences for patients.<\/p>\n\n\n\n

\u201cOnce curative treatments become available, it will be important to accurately identify patients close to developing the different forms of parkinsonism to be able to take a targeted treatment approach\u201d, explains Prof. Kr\u00fcger, principal investigator from Luxembourg in the DEEPEN-iRBD project.<\/p>\n\n\n\n

While Parkinson\u2019s disease is the closest to a pure motor syndrome, with only mild cognitive impairment, dementia with Lewy bodies shows much more severe cognitive impairment, which can lead to hallucinations. Patients with multiple system atrophy show intermediate cognitive impairment relative to Parkinson\u2019s disease and dementia with Lewy bodies but often present particularly prominent autonomic symptoms, such as urinary dysfunction and sudden drops in blood pressure upon standing. The difference in clinical symptoms between the three diseases is mainly due to different types of cells and brain structures being affected by the aggregation of the alpha-synuclein protein.<\/p>\n\n\n\n

\nLuxembourgish expertise and data to further improve early diagnosis and treatment<\/h4>\n\n\n\n

The DEEPEN-iRBD project aims to identify specific profiles beyond iRBD that allow the diagnosis and distinction between the three synucleopathies early on, even in the prodromal phase, before any cognitive or motor symptoms arise. The study will utilise existing and newly acquired data, including physiological signal recordings, molecular markers from body fluids, skin biopsy, and brain cells stemming from reprogrammed patient skin cells. The University of Luxembourg is highly involved in data management, protection, and dissemination, as well as providing data and samples from patients previously diagnosed with iRBD through the nationwide \u201cREM-Sleep Behaviour Study\u201d and the participants of the Luxembourg Parkinson Study. Both studies are being coordinated by the National Centre of Excellence in Research on Parkinson’s disease (NCER-PD), an initiative of the Luxembourg National Research Fund (FNR\/NCER13\/BM\/11264123) supporting the joint effort of the partner institutions, Luxembourg Centre for Systems Biomedicine, Luxembourg Institute of Health, Centre Hospitalier de Luxembourg, and Laboratoire National de Sant\u00e9, in successfully paving the way for precision medicine concepts for Parkinson\u2019s disease.<\/p>\n\n\n\n

Our study can potentially improve early risk identification, diagnosis, treatment and prognosis of patients with iRBD, prone to convert to Parkinson\u2019s disease, multiple system atrophy or dementia with Lewy bodies. The ultimate goal is to be able to implement personalised medicine strategies, which are tailored to each patient and their unique characteristics, instead of treating every person living with a form of parkinsonism the same. This approach can help alleviate symptoms and optimise prevention, diagnosis, and treatment strategies.<\/p>\n\n\n\n

\u201cThis new study will help us develop guidelines on when and how we communicate such early screening results to people with a high risk of developing different forms of parkinsonism in the future.\u201d<\/p>\n\n\n\n

\nAbout NCER-PD<\/h4>\n\n\n\n

The National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD)<\/a> aims to improve the diagnosis and stratification of Parkinson’s disease by combining detailed clinical and molecular data of patients to develop novel disease biomarker signatures. The ultimate goal is to diagnose the disease at an earlier stage and with a higher specificity than is currently possible.<\/p>\n\n\n\n

To this end, the LCSB<\/a> collaborates with clinicians and scientists from the Centre Hospitalier de Luxembourg<\/a> (CHL), the Luxembourg Institute of Health<\/a> (LIH), the Laboratoire National de Sant\u00e9<\/a> (LNS) and the Integrated Biobank of Luxembourg <\/a>(IBBL) to establish a state-of-the-art Parkinson\u2019s disease cohort in which participants are both clinically and molecularly characterised in detail. The consortium is supported by the Luxembourg Research Fund<\/a> (FNR).<\/p>\n\n\n\n

\nAbout RBD-Study<\/h4>\n\n\n\n

The Luxembourg National Sleep Study<\/a> is a research project aimed at understanding the relationship between sleep disorders, such as REM sleep behaviour disorder (RBD), and neurodegenerative diseases, such as Parkinson’s disease. The first phase of the study involved an online survey of over 20,000 Luxembourg residents aged 55-75 to gather information on sleep quality and symptoms of RBD. Participants who show potential symptoms of RBD were then contacted for further assessments, including an at-home smell test and a second questionnaire. The study aims to better understand the early phases of neurodegenerative diseases and determine strategies for preventing them. The large number of participants and the use of non-invasive assessments make this study a valuable contribution to sleep and Parkinson’s disease research.<\/p>\n\n\n\n

\nAbout EraPerMed<\/h4>\n\n\n\n

ERA PerMed<\/a>The DEEPEN-iRBD study is coordinated by Graziella Cappelletti from the University of Milan. Other international partners include the Milan Maugeri Clinical Science Institute, the Lund University, the French National Centre for Scientific Research, the University of Copenhagen, the Danish Parkinson\u2019s Association and the University of Zagreb.<\/a> is a new ERA-Net Cofund, supported by 32 partners from 23 countries and co-funded by the European Commission. To align national research strategies, promote excellence, reinforce the competitiveness of European players in Personalised Medicine, and enhance European collaboration with non-EU countries, national funding organisations have agreed to launch Joint Transnational Calls for collaborative, innovative research projects in Personalised Medicine. <\/p>\n\n\n

\n \n\"\"\n <\/figure><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"

The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism. <\/p>\n","protected":false},"author":56,"featured_media":283,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[3],"news-topic":[18],"organisation":[],"authorship":[56],"acf":[],"yoast_head":"\nDifferentiating typical and atypical parkinsonism early in disease - LCSB - Universit\u00e9 du Luxembourg I Uni.lu<\/title>\n<meta name=\"description\" content=\"The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Differentiating typical and atypical parkinsonism early in disease\" \/>\n<meta property=\"og:description\" content=\"The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"LCSB FR\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-16T11:19:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png\" \/>\n\t<meta property=\"og:image:width\" content=\"720\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/\"},\"author\":{\"name\":\"Ruxandra Soare\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/person\/01f680e81eac3194f3512ea149d78fcb\"},\"headline\":\"Differentiating typical and atypical parkinsonism early in disease\",\"datePublished\":\"2023-04-25T07:00:15+00:00\",\"dateModified\":\"2024-08-16T11:19:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/\"},\"wordCount\":1035,\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png\",\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/\",\"name\":\"Differentiating typical and atypical parkinsonism early in disease - LCSB - Universit\u00e9 du Luxembourg I Uni.lu\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png\",\"datePublished\":\"2023-04-25T07:00:15+00:00\",\"dateModified\":\"2024-08-16T11:19:47+00:00\",\"description\":\"The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png\",\"width\":720,\"height\":720,\"caption\":\"DEEPEN-iRBD logo\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.uni.lu\/fr\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Luxembourg Centre for Systems Biomedicine (LCSB)\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"News\",\"item\":\"https:\/\/www.uni.lu\/lcsb-fr\/news\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Differentiating typical and atypical parkinsonism early in disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#website\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/\",\"name\":\"LCSB\",\"description\":\"Luxembourg Centre for Systems Biomedicine I Uni.lu\",\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#organization\"},\"alternateName\":\"Luxembourg Centre for Systems Biomedicine I Universit\u00e9 du Luxembourg\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.uni.lu\/lcsb-fr\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#organization\",\"name\":\"LCSB - Universit\u00e9 du Luxembourg I Uni.lu\",\"alternateName\":\"Luxembourg Centre for Systems Biomedicine\",\"url\":\"https:\/\/www.uni.lu\/lcsb-fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg\",\"width\":2560,\"height\":2560,\"caption\":\"LCSB - Universit\u00e9 du Luxembourg I Uni.lu\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.linkedin.com\/showcase\/lcsb-university-of-luxembourg\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/person\/01f680e81eac3194f3512ea149d78fcb\",\"name\":\"Ruxandra Soare\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/a02d13347ad0e0be4826e72651dd2973?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/a02d13347ad0e0be4826e72651dd2973?s=96&d=mm&r=g\",\"caption\":\"Ruxandra Soare\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Differentiating typical and atypical parkinsonism early in disease - LCSB - Universit\u00e9 du Luxembourg I Uni.lu","description":"The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/","og_locale":"fr_FR","og_type":"article","og_title":"Differentiating typical and atypical parkinsonism early in disease","og_description":"The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism.","og_url":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/","og_site_name":"LCSB FR","article_modified_time":"2024-08-16T11:19:47+00:00","og_image":[{"width":720,"height":720,"url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#article","isPartOf":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/"},"author":{"name":"Ruxandra Soare","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/person\/01f680e81eac3194f3512ea149d78fcb"},"headline":"Differentiating typical and atypical parkinsonism early in disease","datePublished":"2023-04-25T07:00:15+00:00","dateModified":"2024-08-16T11:19:47+00:00","mainEntityOfPage":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/"},"wordCount":1035,"publisher":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#organization"},"image":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png","inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/","url":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/","name":"Differentiating typical and atypical parkinsonism early in disease - LCSB - Universit\u00e9 du Luxembourg I Uni.lu","isPartOf":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage"},"image":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png","datePublished":"2023-04-25T07:00:15+00:00","dateModified":"2024-08-16T11:19:47+00:00","description":"The new international DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards typical or atypical forms of parkinsonism.","breadcrumb":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#primaryimage","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2023\/04\/differentiating_typical_and_atypical_parkinsonism_early_in_disease.png","width":720,"height":720,"caption":"DEEPEN-iRBD logo"},{"@type":"BreadcrumbList","@id":"https:\/\/www.uni.lu\/lcsb-fr\/news\/differentiating-typical-and-atypical-parkinsonism-early-in-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.uni.lu\/fr"},{"@type":"ListItem","position":2,"name":"Luxembourg Centre for Systems Biomedicine (LCSB)","item":"https:\/\/www.uni.lu\/lcsb-fr\/"},{"@type":"ListItem","position":3,"name":"News","item":"https:\/\/www.uni.lu\/lcsb-fr\/news\/"},{"@type":"ListItem","position":4,"name":"Differentiating typical and atypical parkinsonism early in disease"}]},{"@type":"WebSite","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#website","url":"https:\/\/www.uni.lu\/lcsb-fr\/","name":"LCSB","description":"Luxembourg Centre for Systems Biomedicine I Uni.lu","publisher":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#organization"},"alternateName":"Luxembourg Centre for Systems Biomedicine I Universit\u00e9 du Luxembourg","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.uni.lu\/lcsb-fr\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#organization","name":"LCSB - Universit\u00e9 du Luxembourg I Uni.lu","alternateName":"Luxembourg Centre for Systems Biomedicine","url":"https:\/\/www.uni.lu\/lcsb-fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/22\/2026\/03\/03113045\/LCSB_SM-Profile_1600x1600px-scaled.jpg","width":2560,"height":2560,"caption":"LCSB - Universit\u00e9 du Luxembourg I Uni.lu"},"image":{"@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/showcase\/lcsb-university-of-luxembourg"]},{"@type":"Person","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/person\/01f680e81eac3194f3512ea149d78fcb","name":"Ruxandra Soare","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.uni.lu\/lcsb-fr\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a02d13347ad0e0be4826e72651dd2973?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a02d13347ad0e0be4826e72651dd2973?s=96&d=mm&r=g","caption":"Ruxandra Soare"}}]}},"blog_id":22,"_links":{"self":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/news\/282"}],"collection":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/types\/news"}],"author":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/users\/56"}],"version-history":[{"count":3,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/news\/282\/revisions"}],"predecessor-version":[{"id":324,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/news\/282\/revisions\/324"}],"wp:authorship":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/users\/56"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/media\/283"}],"wp:attachment":[{"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/media?parent=282"}],"wp:term":[{"taxonomy":"news-category","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/news-category?post=282"},{"taxonomy":"news-topic","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/news-topic?post=282"},{"taxonomy":"organisation","embeddable":true,"href":"https:\/\/www.uni.lu\/lcsb-fr\/wp-json\/wp\/v2\/organisation?post=282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}