{"id":169,"date":"2020-07-20T11:02:05","date_gmt":"2020-07-20T11:02:05","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-fr\/news\/50-000-euros-remis-dans-le-cadre-de-la-8e-edition-despoir-en-tete\/"},"modified":"2020-07-20T11:02:05","modified_gmt":"2020-07-20T11:02:05","slug":"50-000-euros-remis-dans-le-cadre-de-la-8e-edition-despoir-en-tete","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/lcsb-fr\/news\/50-000-euros-remis-dans-le-cadre-de-la-8e-edition-despoir-en-tete\/","title":{"rendered":"50 000 euros remis dans le cadre de la 8e \u00e9dition d\u2019Espoir en t\u00eate"},"content":{"rendered":"

Organis\u00e9e pour la 8e ann\u00e9e cons\u00e9cutive, l\u2019action Espoir en t\u00eate, initi\u00e9e par les Rotary Clubs luxembourgeois, a permis de r\u00e9colter 50 000 euros de dons en faveur de la recherche\u00a0sur les maladies du cerveau au Luxembourg.<\/p>

L\u2019action Espoir en t\u00eate permet chaque ann\u00e9e de r\u00e9colter des dons via l\u2019organisation\u00a0d\u2019avant-premi\u00e8res et de projections d\u2019exception dans les cin\u00e9mas Kinepolis du Kirchberg\u00a0et de Belval.<\/p>

En 2020, le film \u00ab The Call of the Wild \u00bb, adaptation du roman de Jack London, \u00e9tait \u00e0\u00a0l\u2019affiche le dimanche 1er\u00a0mars. Invit\u00e9s par les Rotary Clubs luxembourgeois, quelque\u00a03450 spectateurs ont r\u00e9pondu pr\u00e9sents.\u00a0Pour\u00a0chaque place vendue,\u00a0huit euros ont\u00a0\u00e9t\u00e9 revers\u00e9s \u00e0 la recherche sur les maladies du cerveau au Luxembourg.<\/p>

\n \n\"\"\n <\/figure>

Le public a ainsi permis, avec l\u2019appui d\u2019autres donateurs, de r\u00e9colter 50 000 euros.\u00a0Une somme qui financera deux projets de recherche, soutenu chacun \u00e0 hauteur de\u00a025 000 euros, le premier concernant la d\u00e9mence, le second le glioblastome.<\/p>\n

\nLe projet MCI-BIOME (LCSB)<\/h4>\n

La d\u00e9mence est l\u2019un des plus grands d\u00e9fis scientifiques, m\u00e9dicaux et socio-\u00e9conomiques\u00a0de notre \u00e9poque. Elle touche plus de 6500 personnes au Luxembourg, et son incidence\u00a0devrait doubler au cours des\u00a0vingt\u00a0prochaines ann\u00e9es. Aujourd\u2019hui, il n\u2019existe pas de traitement\u00a0m\u00e9dical pour pr\u00e9venir, stopper ou soigner la d\u00e9mence. Les personnes pr\u00e9sentant\u00a0des Troubles Cognitifs L\u00e9gers (TCL) repr\u00e9sentent\u00a0la\u00a0population\u00a0la\u00a0plus expos\u00e9e au risque\u00a0d\u2019\u00e9volution vers la d\u00e9mence.<\/p>

Dans ce contexte, et afin de mieux pr\u00e9venir et r\u00e9duire les risques de d\u00e9velopper une\u00a0d\u00e9mence, le projet de MCI-BIOME s\u2018int\u00e9resse aux liens entre le microbiote intestinal,\u00a0l\u2019environnement social et les TCL. Le but\u00a0est\u00a0d\u2019identifier des signatures microbiennes\u00a0sp\u00e9cifiques\u00a0aux\u00a0personnes pr\u00e9sentant des TLC et d\u2019explorer les\u00a0liens\u00a0entre ces signatures,l\u2019environnement social, notamment l\u2019\u00e9ducation, les facteurs psychologiques, le stress\u00a0per\u00e7u et l\u2019alimentation.<\/p>

\n \n\"\"\n <\/figure>

Ce projet est le fruit d\u2019une collaboration interdisciplinaire entre le Professeur Paul\u00a0\u00a0Wilmes (sp\u00e9cialiste du microbiote, Luxembourg Centre for Systems\u00a0Biomedicine\u00a0(LCSB), Universit\u00e9 du Luxembourg), le Professeur Rejko Kr\u00fcger (expert clinique en\u00a0neurod\u00e9g\u00e9n\u00e9rescence, Centre Hospitalier Luxembourg, Luxembourg Institute of Health, LCSB)\u00a0et le Professeur Anja Leist (sp\u00e9cialiste en recherche socio-\u00e9conomique et psychologique,\u00a0Universit\u00e9 du Luxembourg).<\/p>\n

\nContribution de la reprogrammation des cellules microgliales dans la progression du\u00a0glioblastome (LNS \u2013 NCP & LCNP)<\/h4>\n

Le glioblastome est la plus agressive et r\u00e9sistante des tumeurs c\u00e9r\u00e9brales primaires et\u00a0repr\u00e9sente l\u2019un des cancers les plus meurtriers. M\u00eame avec une prise en charge optimale\u00a0suite au diagnostic, l\u2019esp\u00e9rance de vie est en moyenne de 14 mois seulement. Ce sombre\u00a0pronostic est notamment associ\u00e9 \u00e0 des comportements pro-tumoraux des cellule\u00a0de\u00a0la microglie, les cellules\u00a0immunitaires\u00a0du cerveau. Il est de plus en plus \u00e9vident que ces changements\u00a0comportementaux sont d\u2019origine \u00e9pig\u00e9n\u00e9tique,\u00a0c\u2019est \u00e0 dire issus d\u2019un\u00a0ensemble de m\u00e9canismes repr\u00e9sentant\u00a0le plus\u00a0fin niveau d\u2019interaction entre l\u2019environnement et l\u2019expression g\u00e9nique.<\/p>

L\u2019\u00e9quipe de ce projet a pour objectif de d\u00e9crypter la signature \u00e9pig\u00e9n\u00e9tique de la microglie\u00a0issue de glioblastomes, \u00e0 l\u2019aide de puces de m\u00e9thylation de derni\u00e8re g\u00e9n\u00e9ration.\u00a0D\u00e9chiffrer les m\u00e9canismes responsables du statut pro-tumoral adopt\u00e9 par le syst\u00e8me\u00a0immunitaire c\u00e9r\u00e9bral dans le cas du glioblastome permettrait de d\u00e9velopper non seulement\u00a0de nouvelles approches th\u00e9rapeutiques, mais \u00e9galement des moyens pour pr\u00e9venir\u00a0ou ralentir l\u2019initiation du glioblastome chez les patients risquant de d\u00e9velopper\u00a0ces tumeurs.<\/p>

\n \n\"\"\n <\/figure>

Ce projet de recherche sera men\u00e9 par Lorraine Richart et le professeur Michel Mittelbronn\u00a0au sein de l\u2019unit\u00e9 de recherche du Luxembourg Centre of Neuropathology du\u00a0Laboratoire national de sant\u00e9 (LNS), du LCSB\u00a0et du Luxembourg Institute of Health (LIH).<\/p>\n

\nEspoir en t\u00eate, un succ\u00e8s qui continue<\/h4>\n

Tous les Rotary Clubs luxembourgeois sont fiers d\u2019avoir une nouvelle fois pu contribuer\u00a0\u00e0 la recherche sur les maladies du cerveau au Luxembourg. En 8 ans, leur action a d\u00e9j\u00e0\u00a0permis de r\u00e9colter 376 000 euros de dons gr\u00e2ce \u00e0 l\u2019action Espoir en t\u00eate. Et une nouvelle\u00a0\u00e9dition est d\u2019ores et d\u00e9j\u00e0 pr\u00e9vue en 2021.<\/p>

Faites un don \u00e0 l\u2019Association Luxembourgeoise des OEuvres du Rotary avec la mention\u00a0\u00ab Espoir en t\u00eate \u00bb sur le compte bancaire IBAN LU94 0081 7737 4700 1003 (BLUXLULL).<\/p>

Plus d\u2019infos sur www.espoir-en-tete.lu<\/a><\/strong><\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"

Organis\u00e9e pour la 8e ann\u00e9e cons\u00e9cutive, l\u2019action Espoir en t\u00eate, initi\u00e9e par les Rotary Clubs luxembourgeois, a permis de r\u00e9colter 50 000 euros de dons en faveur de la recherche\u00a0sur les maladies du cerveau au Luxembourg.<\/p>\n","protected":false},"author":0,"featured_media":170,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[3],"news-topic":[18],"organisation":[],"authorship":[],"acf":[],"yoast_head":"\n50 000 euros remis dans le cadre de la 8e \u00e9dition d\u2019Espoir en t\u00eate - 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