{"id":129,"date":"2020-02-25T09:07:23","date_gmt":"2020-02-25T09:07:23","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-fr\/news\/launch-of-new-eu-research-project-immuniverse\/"},"modified":"2020-02-25T09:07:23","modified_gmt":"2020-02-25T09:07:23","slug":"launch-of-new-eu-research-project-immuniverse","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/lcsb-fr\/news\/launch-of-new-eu-research-project-immuniverse\/","title":{"rendered":"Launch of new EU research project ImmUniverse"},"content":{"rendered":"<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><p>The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is part of a new\u00a0European transdisciplinary consortium\u00a0aiming at transforming\u00a0diagnosis and\u00a0therapy of\u00a0immune-mediateddiseases. Called ImmUniverse, this project will\u00a0focus on common biomarkers in Ulcerative Colitis and Atopic Dermatitis. It has\u00a0officially kicked\u00a0off its activities\u00a0on 24-25 February 2020.<\/p><p>By looking into the common disease mechanisms of Ulcerative Colitis and Atopic Dermatitis, the 26 European partners collaborating in this\u00a0new research project aim at improving diagnostic and therapeutic options for patients living with these conditions. Through molecular profiling techniques, the team will identify signatures of biomarkers and mechanistic principles which reveal information on disease severity and progression enabling personalised therapy decisions for each patient at the right time. The project will run for a period of five years with a total budget of EUR 31 million provided by the <a href=\"https:\/\/www.imi.europa.eu\" target=\"_blank\" title=\"\" rel=\"noopener\">Innovative Medicines Initiative<\/a> (IMI 2), a Joint Undertaking of the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA). Of the total budget, 50% are contributed by the EFPIA partners and 50% by the EU.<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"a-heterogeneous-group-of-diseases\"\n    >\nA heterogeneous group of diseases<\/h2>\n<p>Immune-mediated inflammatory diseases (IMIDs) are an increasing medical burden in industrialised countries worldwide. They are characterised by an enormous heterogeneity with regard to disease outcome and response to targeted therapies, which often cannot be adequately tailored to individual patients. Hence, an in-depth understanding of this heterogeneity and the biomarkers which predict disease control and therapy response over time are important prerequisites for future precision medicine strategies in IMIDs. The pathogenic components (\u201comics\u201d) responsible for the disease outcome in each individual patient, i.e. environment, genes, gut microbiota or the immune system, are remarkably multifactorial, with thousands of constituents all interacting with and impacting on each other.<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"international-and-interdisciplinary-consortium\"\n    >\nInternational and interdisciplinary consortium<\/h2>\n<p><a href=\"https:\/\/www.immuniverse.eu\" target=\"_blank\" title=\"\" rel=\"noopener\">ImmUniverse<\/a> has been formed as a European transdisciplinary consortium to tackle these unmet needs and pave the way towards a truly personalised disease understanding of two different IMIDs: Ulcerative Colitis and Atopic Dermatitis. Following a unique cross-disease approach, the multinational project will fill the gap and address the limitations of current studies by systematically comparing the complex interactions between recirculating immune cells and the respective tissue microenvironment. The novel, circulating biomarker assays are expected to improve diagnosis,\u00a0inform about disease severity and progression early in the clinical course, and\u00a0enable treatment response and remission monitoring.<\/p><p>To this end, the ImmUniverse research team will employ state-of-the-art multi-omics profiling technologies, including single-cell RNA sequencing, metabolomics and advanced data management and bioinformatics pipelines.\u00a0<\/p><p>\u201cUnlike previous studies in the field, we will specifically compare signatures from the same individual over time, capturing the full range of disease activity. We expect this approach to provide us with valuable insights into the interaction between the factors affecting disease progression and therapy response\u201d, says Professor Silvio Danese, Professor of Gastroenterology at Humanitas University in Milan, Italy, and Scientific Coordinator of the project.<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"the-lcsb-leads-bioinformatics-approaches\"\n    >\nThe LCSB leads bioinformatics approaches<\/h2>\n<p>Within the consortium, the LCSB is leading the bioinformatics activities: building platforms and developing strategies to facilitate the efficient management and analysis of the data collected. The members of the\u00a0<a href=\"https:\/\/wwwen.uni.lu\/lcsb\/research\/bioinformatics_core\" target=\"_blank\" title=\"\" rel=\"noopener\">Bioinformatics Core<\/a>\u00a0of the LCSB will design and implement a secure IT infrastructure allowing long-term housing of data within the consortium and access for all partners. They will be in charge of data curation and harmonisation, as well as establishing a virtual biobank to catalogue biospecimens collected. The team will also work on data integration and analysis, for example developing machine learning methods for multi-omics based prediction and disease classification.<\/p><p>The LCSB researchers will use the expertise they acquired working in previous IMI consortium such as\u00a0<a href=\"https:\/\/www.etriks.org\/\" target=\"_blank\" title=\"\" rel=\"noopener\">eTRIKS<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.aetionomy.eu\/\" target=\"_blank\" title=\"\" rel=\"noopener\">Aetionomy<\/a>, and leverage the open source and open data principles developed within these projects.<\/p><p><\/p><p><\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-partners\"\n    >\nProject partners<\/h2>\n<p>The project team comprises 16 academic partners, led by Humanitas University, five industrial project partners, co-led by GlaxoSmithKline (GSK) and Sanofi, as well as two small and medium-sized enterprises. This includes IMID-experienced clinicians and drug developers, basic immunologists, bioinformaticians as well as biotechnology and clinical development experts. Many of the partners have been involved in defining both European and international standards for interdisciplinary clinical care for IMIDs patients, with the intent to facilitate the transfer of high-quality clinical data and biomaterials into clinical research. Furthermore, the consortium is complemented by three European patient organisations to ensure efficient dialogue and a continuous focus on the actual needs of patients living with Ulcerative Colitis and Atopic Dermatitis.<\/p><p><\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Austria<\/li><\/ul><p>AIT Austrian Institute of Technology GmbH<\/p><p>JOANNEUM RESEARCH Forschungsgesellschaft mbH<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Belgium<\/li><\/ul><p>European Federation of Allergy and Airways Diseases Patients&rsquo; Associations<\/p><p>European Federation of Crohn\u2019s and Ulcerative Colitis Associations<\/p><p>Katholieke Universiteit Leuven<\/p><p>Vlaams Instituut voor Biotechnologie<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Denmark<\/li><\/ul><p>Aarhus Universitet<\/p><p>Aarhus Universitetshospital<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">France<\/li><\/ul><p>Centre Hospitalier R\u00e9gional Universitaire Nancy<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Germany<\/li><\/ul><p>Christian Albrechts-Universit\u00e4t zu Kiel\u00a0<\/p><p>EURICE &#8211; European Research and Project Office GmbH<\/p><p>Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen<\/p><p>Sanofi-Aventis Deutschland GmbH<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Italy<\/li><\/ul><p>Humanitas University<\/p><p>Instituto Superiore de Sanit\u00e0<\/p><p>Scuola Superiore di Studi Universitari e di Perfezionamento Sant&rsquo;Anna<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Luxembourg<\/li><\/ul><p>European Patients Forum\u00a0<\/p><p>Information Technology for Translational Medicine (ITTM) SA<\/p><p>Universit\u00e9 du Luxembourg<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Netherlands<\/li><\/ul><p>Academisch Medisch Centrum Universiteit van Amsterdam<\/p><p>Radboud Universitair Medisch Centrum (Radboudumc) Nijmegen<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">Switzerland<\/li><\/ul><p>Novartis Pharma AG<\/p><ul class=\"ulux-list\"><li class=\"ulux-list-item\">United Kingdom<\/li><\/ul><p>Eli Lilly and Company Limited\u00a0<\/p><p>GlaxoSmithKline Research &#038; Development Limited<\/p><p>Pfizer Limited<\/p><p>University of Cambridge<\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is part of a new\u00a0European transdisciplinary consortium\u00a0aiming at transforming\u00a0diagnosis and\u00a0therapy of\u00a0immune-mediateddiseases. Called ImmUniverse, this project will\u00a0focus on common biomarkers in Ulcerative Colitis and Atopic Dermatitis. It has\u00a0officially kicked\u00a0off its activities\u00a0on 24-25 February 2020.<\/p>\n","protected":false},"author":0,"featured_media":130,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[],"news-topic":[18],"organisation":[],"authorship":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Launch of new EU research project ImmUniverse - LCSB - Universit\u00e9 du Luxembourg I Uni.lu<\/title>\n<meta name=\"description\" content=\"The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is part of a new\u00a0European transdisciplinary consortium\u00a0aiming at transforming\u00a0diagnosis and\u00a0therapy of\u00a0immune-mediateddiseases. Called ImmUniverse, this project will\u00a0focus on common biomarkers in Ulcerative Colitis and Atopic Dermatitis. It has\u00a0officially kicked\u00a0off its activities\u00a0on 24-25 February 2020.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/lcsb-fr\/news\/launch-of-new-eu-research-project-immuniverse\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Launch of new EU research project ImmUniverse\" \/>\n<meta property=\"og:description\" content=\"The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is part of a new\u00a0European transdisciplinary consortium\u00a0aiming at transforming\u00a0diagnosis and\u00a0therapy of\u00a0immune-mediateddiseases. 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