{"id":125,"date":"2019-12-04T10:15:36","date_gmt":"2019-12-04T10:15:36","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-fr\/news\/making-novel-therapeutics-safer\/"},"modified":"2019-12-04T10:15:36","modified_gmt":"2019-12-04T10:15:36","slug":"making-novel-therapeutics-safer","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/lcsb-fr\/news\/making-novel-therapeutics-safer\/","title":{"rendered":"Making novel therapeutics safer"},"content":{"rendered":"

Interdisciplinary EU consortium develops innovative model systems for the evaluation of immunomodulating therapeutics.<\/p>\n

\nNew ways of examining immunomodulatory therapies<\/h2>\n

The Luxembourg Centre for Systems Biomedicine of the University of Luxembourg participates in an EU project to develop innovative model systems for the evaluation of immunomodulatory therapeutics.<\/p>

The development of immunomodulatory agents and therapies has received fresh impetus following the latest successes in immuno-oncology. And cancer medicine is not the only area where cell and gene therapies are increasingly taking hold as alternatives or complementary to classic, low-molecular drugs and biologicals.<\/p>

A significant challenge facing the development of new therapies, however, is and remains their preclinical evaluation in terms of efficacy and safety. The greatest problem here is the complexity of the human immune system. When a person is ill, for example in the case of cancer, autoimmune or inflammatory diseases, the cells of the immune system interact differently to when a person is healthy. While preclinical tests have so far mainly looked at the basic toxicity of a new therapeutic agent in terms of the (healthy) immune system, there is a lack of non-clinical models that accurately capture the individual interactions of the human immune system in the pathogenic state.<\/p>

The EU consortium imSAVAR (Immune\u00a0Safety\u00a0Avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies) is addressing this shortfall by coming up with new ways of examining immunomodulatory therapies. The aim here is to improve existing model systems and develop new ones in order to:<\/p>

– identify adverse side effects of new therapies affecting the immune system,<\/p>

– develop new biomarkers for diagnosing and predicting immune-mediated pharmacology and toxicities, and<\/p>

– further explore toxicity mechanisms and the potential for their mitigation via therapeutic interventions.<\/p>

The project hopes to lay the foundations for new Europe-wide standards in drug development.<\/p>\n

\nA large\u00a0interdisciplinary\u00a0consortium<\/h2>\n

The interdisciplinary imSAVAR consortium is made up of 28 international partners from 11 nations and is being coordinated by the Fraunhofer Institute for Cell Therapy and Immunology<\/a> (Leipzig, Germany) and Novartis<\/a>. Partners include university and non-university research facilities, pharmaceutical and biotechnology companies, as well as regulatory authorities.<\/p>

The Bioinformatics Core<\/a> team at the LCSB is leading the data management activity and the integrated data analysis platform. The goal is to provide a platform to enable secure, scalable and integrated storage as well as exploration and sharing of data. \u201cThis is crucial to the efficient information exchange and collaboration within the project,\u201d explains Prof. Dr Reinhard Schneider, head of the Bioinformatics Core and of ELIXIR Luxembourg. The sustainability of the data and the platform will be supported by the ELIXIR Luxembourg Node<\/a>.<\/p>

Further information on the project will be available from February 2020 on the website\u00a0www.imsavar.eu<\/a>.<\/p>

\n \n\"\"\n

\n imSAVAR Kick off Meeting on December 2. 2019 at Fraunhofer IZI in Leipzig \u00a9 Fraunhofer IZI <\/p>\n <\/figure>

—<\/p>

This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 853988. This Joint Undertaking receives support from the European Union\u2019s Horizon 2020 research and innovation programme and EFPIA.<\/p>

imSAVAR project consortium:<\/p>

BioSci Consulting, Belgium<\/p>

bluebird bio, Inc. United States<\/p>

Boehringer Ingelheim, United States<\/p>

Covance, United Kingdom<\/p>

Dynamic42 GmbH, Germany<\/p>

F. Hoffmann-La Roche Ltd, Switzerland<\/p>

Fraunhofer Institute for Cell Therapy and Immunology IZI, Germany<\/p>

Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Germany<\/p>

Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Germany<\/p>

Fraunhofer Institute for Material and Beam Technology IWS, Germany<\/p>

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Germany<\/p>

Hannover Medical School (MHH), Germany<\/p>

IT for Translational Medicine S.A. (ITTM), Luxembourg<\/p>

Jena University hospital, Germany<\/p>

JDRF, United States<\/p>

Leiden University, The Netherlands<\/p>

Leipzig University, Germany<\/p>

Lund University, Sweden<\/p>

Merck KGaA, Germany<\/p>

Merck Sharp & Dohme Corp., United States<\/p>

Novartis AG, Switzerland<\/p>

Medical University of Innsbruck, Austria<\/p>

Paul-Ehrlich-Institut (PEI), Germany<\/p>

Sanofi, France<\/p>

Servier, France<\/p>

T-CURX GmbH, Germany<\/p>

Transgene SA, France<\/p>

University Hospital of W\u00fcrzburg, Germany<\/p>

University Hospital of T\u00fcbingen, Germany<\/p>

University of Luxembourg, Luxembourg<\/p>

University of Oslo, Norway<\/p>

University of Twente, The Netherlands<\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"

Interdisciplinary EU consortium develops innovative model systems for the evaluation of immunomodulating therapeutics.<\/p>\n","protected":false},"author":0,"featured_media":126,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[],"news-topic":[18],"organisation":[],"authorship":[],"acf":[],"yoast_head":"\nMaking novel therapeutics safer - 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