{"id":685,"date":"2023-06-27T20:43:03","date_gmt":"2023-06-27T20:43:03","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-en\/?post_type=research-groups&#038;p=685"},"modified":"2025-08-06T11:31:04","modified_gmt":"2025-08-06T09:31:04","slug":"research","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/neuroinflammation\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><!-- SecondaryNavigationMirror --><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"13caf496-3ee8-4e1c-8607-5eec99c8e22d\">\n    <nav id=\"secondary-navigation\" role=\"navigation\" aria-label=\"Secondary menu\" class=\"secondary-nav\">\n        <button class=\"secondary-nav__button btn btn-solid--primary w-full\" aria-expanded=\"false\" aria-controls=\"secondary-navigation__list\" title=\"The selected page is Research\" type=\"button\">\n            <span class=\"btn__name mr-auto\">Research<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/neuroinflammation\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Overview<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/neuroinflammation\/research\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link isactived\" aria-current=\"page\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Research<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/neuroinflammation\/publications\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Publications<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/neuroinflammation\/people\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<!-- end SecondaryNavigationMirror --><\/div><\/section>\n\n\n<section class=\"section  wp-block-unilux-blocks-content-card-full-width \">\n    <div class=\"container 2xl:max-w-screen-2xl\">\n        <div class=\"max-w-11\/12\">\n            <div class=\"content-card content-card--right content-card__overlay--hidden wp-block-unilux-blocks-content-card\">\n    \n<h2 class=\"content-card__heading has-text-align-left wp-block-unilux-blocks-heading\"        id=\"our-research\"\n    >\nOur research<\/h2>\n<div class=\"content-card__visual wp-block-unilux-blocks-content-card-visual-area\">\n    \n<section class=\"wp-block-unilux-blocks-image-video-wrapper\">\n    <figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"TNT-like structures between neurons and microglia, visualised by scanning electron microscopy\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/31141636\/TNTs-between-neurons-and-microglia-visualised-by-scanning-electron-microscopy_D-Budinger.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/31141636\/TNTs-between-neurons-and-microglia-visualised-by-scanning-electron-microscopy_D-Budinger-300x225.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/31141636\/TNTs-between-neurons-and-microglia-visualised-by-scanning-electron-microscopy_D-Budinger-1024x768.jpg 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/31141636\/TNTs-between-neurons-and-microglia-visualised-by-scanning-electron-microscopy_D-Budinger-768x576.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/31141636\/TNTs-between-neurons-and-microglia-visualised-by-scanning-electron-microscopy_D-Budinger.jpg 1500w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 3\/2; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>            <p class=\"wp-block-dev4-reusable-blocks-image-caption\">\n            TNT-like structures between neurons and microglia, visualised by scanning electron microscopy        <\/p>\n    <\/figure><\/section>\n<div class=\"wp-block-unilux-blocks-wrapper content-card__overlay\">\n<a class=\"wp-block-unilux-blocks-button-highlight-rounded bottom-left\" \n    href=\"#\"\n    target=\"_self\"\n>\n    \n<span class=\"btn-highlight-rounded__name wp-block-unilux-blocks-plain-text\"><\/span>    <span class=\"icon-rounded\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right icon--lg\"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/span>\n<\/a><\/div>\n<\/div><div class=\"content-card__body  wp-block-unilux-blocks-content-card-free-area\">\n    \n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Neuroinflammation is a hallmark of neurodegenerative diseases such as Alzheimer\u2019s (AD). AD is characterised by the accumulation of extracellular amyloid-beta (A\u03b2) in amyloid plaques and intracellular tau in neurofibrillary tangles (NFTs). The activation of the innate immune cells of the brain, called microglia, seems to be involved in the development and progression of this and other neurodegenerative diseases. To date, the underlying mechanisms in the transition of an initially protective to a chronic and harmful neuroinflammatory response are unknown.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>The group aims at understanding molecular mechanisms of inflammatory regulation in a variety of neurodegenerative diseases, using novel mouse models and state-of-the-art techniques like two-photon imaging, transcriptome analysis and induced pluripotent stem cells (iPSCs). The group also studies the cellular interactions between microglia, neurons, astrocytes, and oligodendrocytes through tunnelling nanotubes. From a translational perspective, the goal of the group is to develop new biomarkers and insights into medical interventions around various aspects of neuroinflammation involved in neurodegenerative and cerebrovascular diseases.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>        <\/div>\n    <\/div>\n<\/section>\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"our-research-projects\"\n    >\nOur research projects<\/h2>\n\n\n\n<p>This section introduces current projects of the Neuroinflammation group.<\/p>\n\n\n\n<div class=\"wp-block-unilux-blocks-accordion accordion accordion--theme accordion-standard\" data-reference=\"28bfc471-f24a-416d-8f4e-75df6eac29d3\" data-accordion-type=\"standard\"><div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"microglia-neuron-interaction-in-alzheimers-disease-bridging-from-basic-research-to-clinical-applications-for-diagnostics-and-therapy-minialz\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-3ff1fafe-02a3-4bda-9039-99e6294f2ec3\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-3ff1fafe-02a3-4bda-9039-99e6294f2ec3\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-3ff1fafe-02a3-4bda-9039-99e6294f2ec3\"\n        >\n            <span class=\"accordion__title\">\n                                Microglia-neuron interaction in Alzheimer\u2019s disease: bridging from basic research to clinical applications for diagnostics and therapy (MINIALZ)            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-3ff1fafe-02a3-4bda-9039-99e6294f2ec3\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-3ff1fafe-02a3-4bda-9039-99e6294f2ec3\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>5 years (2023 \u2013 2027)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>FNR PEARL Programme \/ University of Luxembourg<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Michael T. HENEKA, Sean-Patrick H. RIECHERS, Sofie-Helene SEIBEL, Pablo BOTELLA LUCENA, Dimitri BUDINGER, Vivian Song-Minkyung BAKER, Beatriz ALMEIDA, Zhe LIU (past member), Michele Fabrizio CALIANDRO, Hugo Filipe RANGEL DA COSTA<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Dementia has been identified by the Word Health Organization as a major and global health issue. Indeed, we expect an increase from currently 55 million dementia cases to about 150 million in 2050. Approximately two thirds of all dementia patients are suffering from Alzheimer\u2019s disease (AD), a neurodegenerative disorder that leads to memory dysfunction, behavioral disturbances, and loss of all higher cognitive functions.<\/p>\n\n<p>PEARL MINIALZ aims to investigate direct cellular interactions between microglia and neurons by tunnelling nanotubes (TNTs). Initial data suggest that microglia can establish TNTs with neurons, enabling them to clear pathological protein aggregates and facilitate organelle trafficking between cells. The transport of aggregates via TNTs in AD and its degradation by microglia may play a critical role in preserving neuronal function and integrity. In this project, we will use different disease models to address this question. We will use microglia and neurons differentiated from patient-derived induced pluripotent stem cells (iPSC), as well as primary murine cells and cell lines, to comprehensively investigate, in the context of AD, the formation of TNTs and the functional transfer\/modification of cargo through these structures using confocal live imaging techniques. We will further validate findings in fish and rodent models with state-of-the-art 3D super-resolution microscopy and multi-photon <em>in vivo<\/em> microscopy. Finally, we will validate our findings in microglia and neurons differentiated from iPSCs derived from patients.<\/p>\n\n<p>In addition we will also assess whether modulating TNT formation between neurons and microglia could open up new therapeutic or diagnostic avenues for the treatment of AD.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"role-of-microglial-mechanoreceptor-mediated-clearance-of-a%ce%b2-in-alzheimers-disease-rebalance\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-36ead6ba-1faa-4df2-bebd-326bab6ac9f8\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-36ead6ba-1faa-4df2-bebd-326bab6ac9f8\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-36ead6ba-1faa-4df2-bebd-326bab6ac9f8\"\n        >\n            <span class=\"accordion__title\">\n                                Role of microglial mechanoreceptor mediated clearance of A\u03b2 in Alzheimer\u2019s disease (REBALANCE)            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-36ead6ba-1faa-4df2-bebd-326bab6ac9f8\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-36ead6ba-1faa-4df2-bebd-326bab6ac9f8\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>4 years (2023 \u2013 2026)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>EU Joint Programme \u2013 Neurodegenerative Disease Research (JPND)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Hilmi Jaufer THAMEEMUL ANSARI<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<ol type=\"1\" class=\"ulux-list\">\n<li class=\"ulux-list-item\">Tarja Malm, University of Eastern Finland, Finland<\/li>\n\n\n\n<li class=\"ulux-list-item\">Meaghan O\u2019Reilly, Sunnybrook Research Institute\/University of Toronto, Canada<\/li>\n\n\n\n<li class=\"ulux-list-item\">Arn M.J.M. van den Maagdenberg, Leiden University Medical Center, Netherlands<\/li>\n\n\n\n<li class=\"ulux-list-item\">Denis Vivien, INSERM \u2013 Caen Normandie University and Hospital, France<\/li>\n\n\n\n<li class=\"ulux-list-item\">Signe Me\u017einska, University of Latvia, Latvia<\/li>\n\n\n\n<li class=\"ulux-list-item\">Else Tolner, Leiden University Medical Centre, Netherlands<\/li>\n<\/ol>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>The project aims to elucidate key cellular\u2013molecular targets and mechanisms by which the mechanoreceptor PIEZO1 and other mechanoreceptors are used by microglia to sense A\u03b2 deposit stiffness, and to clear A\u03b2 deposits upon cellular activation. We will treat induced pluripotent stem cell (iPSC) differentiated microglia and rodent primary microglia with mechanoreceptor agonists, mechanical stimulation, and stimuli combinations to assess their role in microglial phagocytosis, lysosomal functions, and inflammatory processes in an AD context. We will use CRSIPR-Cas9 constructs or antagonist against respective membrane proteins in iPSC-derived microglia to study loss of function phenotypes.<\/p>\n\n<p>In murine models of cerebral amyloidosis, we will assess microglial morphology at A\u03b2 deposits and their clearance by microglia using multi-photon in vivo laser scanning microscopy. Results will be validated by FACS-mediated isolation from the adult brain and analysis of microglia containing phagocytosed A\u03b2. Isolated microglia from brains will also subjected for scRNA-Seq in order to dissect pathways involved in mechanoreceptor-dependent microglial immune activation. Furthermore, we will evaluate neuronal network activity and behavioral phenotypes after activating mechanoreceptors in the models described above. We will monitor neuronal calcium transients and study learning and memory behavior.<\/p>\n\n<p>In summary, we will generate new information on possible therapeutic effects of microglial mechanoreceptor activation with the aim to maintain microglial homeostasis and clearance capacity.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"the-nlrp3-inflammasome-in-the-development-and-progression-of-tau-pathology\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-b61c1b05-6831-481a-9e84-a3f03abd8a06\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-b61c1b05-6831-481a-9e84-a3f03abd8a06\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-b61c1b05-6831-481a-9e84-a3f03abd8a06\"\n        >\n            <span class=\"accordion__title\">\n                                The NLRP3 Inflammasome in the Development and Progression of Tau Pathology            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-b61c1b05-6831-481a-9e84-a3f03abd8a06\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-b61c1b05-6831-481a-9e84-a3f03abd8a06\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>2 Years (2023 \u2013 2025)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>European Molecular Biology Organization (EMBO) Fellowship<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Bora TASTAN<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Alzheimer&#8217;s disease (AD) is characterised by three hallmark pathologies \u2013 the accumulation of amyloid-beta (A\u03b2) in extracellular plaques, the aggregation of hyperphosphorylated tau in intracellular neurofibrillary tangles (NFT), and neuroinflammation. &nbsp;&nbsp; However, little is currently known about how these pathologies connect. Research over the past decade has shown that microglia, the innate immune cells of the brain, can sense aggregated A\u03b2. This leads to the assembly of the NLRP3 inflammasome, which consists of the intracellular pattern recognition receptor NLRP3, the adaptor protein ASC, and the effector enzyme caspase-1. Subsequently, microglia produce and secrete several inflammatory mediators, including IL-1\u03b2 and ASC protein complexes termed as ASC specks. Interestingly, A\u03b2 plaque formation seems to precede tau pathology, and several studies have demonstrated that A\u03b2 fibrils could induce tau seeding and spreading. While microglia depletion, as well as genetic knockout of ASC, were found to reduce spread in an <em>in vivo<\/em> tau spread model, the influence of the NLRP3 inflammasome on neuronal tau pathology and tau pathology downstream of A\u03b2 has yet to be elucidated. We hypothesize that genetic knockout of either ASC or Nlrp3 not only affects the transcriptome in microglia, but also induces transcriptomic changes in astrocytes and neurons in a non-cell-autonomous manner. We further predict that the NLRP3 inflammasome is important for cellular senescence in tauopathies and for the formation and maintenance of neuronal spines. We will also test for the ability of the NLRP3 inflammasome to modulate A\u03b2-induced tau pathology and investigate if isolated ASC specks are able to induce tau phosphorylation and tangle formation.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"asc-speck-driven-amyloid-deposition-as-possible-target-to-prevent-alzheimers-disease-u-agr-8180-00\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-c911de2d-43dd-4979-b370-37b1edaedf96\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-c911de2d-43dd-4979-b370-37b1edaedf96\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-c911de2d-43dd-4979-b370-37b1edaedf96\"\n        >\n            <span class=\"accordion__title\">\n                                ASC-speck driven Amyloid deposition as possible target to prevent Alzheimer&#8217;s disease (U-AGR-8180-00)            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-c911de2d-43dd-4979-b370-37b1edaedf96\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-c911de2d-43dd-4979-b370-37b1edaedf96\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>4 years (2022 \u2013 2026)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>The Gerhard and Ilse Schick Foundation (Gerhard und Ilse Schick Stiftung)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Masanori ITAKURA, Beatriz ALMEIDA,Adrien RAUH (past member), Archontia Maria ANANIADOU (past member)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>AC Immune SA, Switzerland<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>In Alzheimer\u2019s Disease (AD), evidence show that ASC speck formation downstream of the NLRP3 inflammasome activation underlies the deposition of amyloid-beta (A\u03b2). ASC specks can be defined as micrometer sized protein complexes with complex physiological roles arising from ASC-dependent inflammasome activation. Once released into the extracellular space in response to pyroptosis, ASC specks were shown to directly interact with A\u03b2 and serve as a seed for A\u03b2 aggregation&nbsp; <em>in vitro<\/em> and <em>in vivo<\/em>. ASC specks are therefore promising targets for novel therapeutic approaches aiming at slowing down AD progression. Our project consists of using diverse molecular biology and imaging techniques to further define the dynamics of pyroptosis and ASC speck release. We will further evaluate if anti-ASC antibodies prevent or slow-down A\u03b2 aggregation induced by ASC specks <em>in vitro<\/em> and <em>in vivo<\/em>.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"inflammation-and-amyloid-from-atoms-to-tissue-aminf\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-e60bcead-3e53-447c-b58e-a3948f5ca57f\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-e60bcead-3e53-447c-b58e-a3948f5ca57f\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-e60bcead-3e53-447c-b58e-a3948f5ca57f\"\n        >\n            <span class=\"accordion__title\">\n                                Inflammation and Amyloid from Atoms to Tissue (AMINF)            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-e60bcead-3e53-447c-b58e-a3948f5ca57f\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-e60bcead-3e53-447c-b58e-a3948f5ca57f\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>2 years (2023 \u2013 2025)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>University of Luxembourg (IAS Audacity)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Laurent MARICHAL, Archontia Maria ANANIADOU (past member)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Theoretical Chemical Physics research group (Prof. Alexandre TKATCHENKO) at the University of Luxembourg<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>During inflammatory responses, reactive oxygen and nitrogen species are produced and interact promiscuously with endogenous molecules, including aggregation-prone peptides. In the context of amyloid diseases, such as Alzheimer\u2019s disease (AD), it is well-established that inflammatory damage can exacerbate the aggregation and neurotoxicity of amyloid-beta (A\u03b2) peptides. However, the precise mechanisms underlying this process remain unclear. Notably, under nitro-oxidative stress A\u03b2 can undergo a post-translational modification called nitration, as it was shown in Alzheimer\u2019s disease (AD) patient brains. Furthermore, nitrated A\u03b2 seems to form aggregates at a different rate compared to unmodified A\u03b2. The exact link between nitrated A\u03b2 and AD is currently not understood. Therefore, the goal of this project is to combine experimental and computational approaches in order unravel the mechanisms behind the effect of A\u03b2 nitration in the context of AD. This project involves a collaboration with the Theoretical Chemical Physics department at UL.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"studying-the-regulation-of-nlrp3-inflammasome-in-asc-dependent-and-independent-pathways-of-alzheimers-disease\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-4c33c585-5cf9-4380-9e52-07b4ce0d4575\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-4c33c585-5cf9-4380-9e52-07b4ce0d4575\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-4c33c585-5cf9-4380-9e52-07b4ce0d4575\"\n        >\n            <span class=\"accordion__title\">\n                                Studying the regulation of NLRP3 inflammasome in ASC-dependent and independent pathways of Alzheimer\u2019s disease            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-4c33c585-5cf9-4380-9e52-07b4ce0d4575\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-4c33c585-5cf9-4380-9e52-07b4ce0d4575\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>4 years (2023 \u2013 2026)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>PI funding (University of Luxembourg)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Shilauni DADWAL<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>The regulation of the NLRP3 inflammasome, a critical component of the innate immune system, is a complex and dynamic process. In this project, we will delve into how NEK7, MARK4, GBP5, PKR, AKT, BTK, and other proteins regulate the NLRP3 inflammasome, and explore their potential connections in the downstream cascade of ASC-dependent and independent pathways.<\/p>\n\n<p>NEK7 has been identified as a critical player in NLRP3 inflammasome activation. Indeed, NEK7 binding induces a conformational change in NLRP3, allowing its oligomerization and subsequent inflammasome assembly. MARK4 kinase is also implicated in NLRP3 inflammasome regulation. Guanylate-binding proteins (GBPs) can promote NLRP3 inflammasome assembly and cytokine release during specific infections. Protein kinase PKR has been shown to negatively regulate NLRP3 inflammasome activation by phosphorylating and inhibiting RIPK1 kinase, which is involved in inflammasome signaling. The AKT kinase can phosphorylate NLRP3 and promote its degradation, thus acting as a direct negative regulator. Bruton&#8217;s tyrosine kinase (BTK) is associated to NLRP3 inflammasome activation in the context of autoimmune diseases, and BTK inhibitors have shown promise in reducing inflammasome-driven inflammation.<\/p>\n\n<p>The interconnections between these inflammatory cascade regulators are an exciting area of research. Some of these kinases may act sequentially or synergistically, while others may counteract each other&#8217;s effects. Elucidating these interactions will be critical to understand the precise regulatory mechanisms of NLRP3 inflammasome activation in microglia, and consequently develop targeted therapies for inflammatory diseases. Thus, this project aims to provide a comprehensive understanding of how the NLRP3 inflammasome is regulated in canonical, non-canonical, and alternative pathways in rodent and human microglia. By uncovering the intricate interplay between these regulators, we can contribute to a more nuanced understanding of inflammasome biology, which has significant implications for therapeutic interventions in inflammatory diseases.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"identification-of-nlrp1-mediated-regulation-of-microglial-immune-metabolism-in-models-of-ageing-and-neurodegeneration\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-6f803210-58cc-48bd-9c5f-c307c737fcb9\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-6f803210-58cc-48bd-9c5f-c307c737fcb9\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-6f803210-58cc-48bd-9c5f-c307c737fcb9\"\n        >\n            <span class=\"accordion__title\">\n                                Identification of NLRP1 mediated regulation of microglial immune metabolism in models of ageing and neurodegeneration            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-6f803210-58cc-48bd-9c5f-c307c737fcb9\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-6f803210-58cc-48bd-9c5f-c307c737fcb9\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>3-4 years (2023 \u2013 2026\/27)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>NextImmune2 Doctoral Training Unit (FNR PRIDE Programme)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Shreya Yashraj REGE<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Activation of microglia and subsequent formation of NACHT, LRR and PYD domains-containing protein 3 and 1 (NLRP3, NLRP1) have been implicated in aging and neurodegenerative disease. Recent evidence suggests that NLRP3 and NLRP1 have gene regulatory effects that directly connect their assembly to the innate immune metabolism of microglia, presumably through the regulation of key elements of the Krebs cycle. In our project, we will investigate, using human iPSC-derived microglia as an experimental model, how NLRP1-mediated gene regulation influences (i) microglial transcriptomes and (ii) microglial function, which are key for maintaining synaptic integrity and neuronal plasticity. Since microglial senescence has been found to cause tau pathology, a major phenotype of the aging and degenerating brain, we will further study (iii) how NLRP1 affects microglial senescence and renewal in the respective models.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"investigating-the-role-of-post-translational-modifications-of-pathogenic-molecules-on-microglial-function\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-1321d25d-720c-4a6d-b784-aea1153feeca\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-1321d25d-720c-4a6d-b784-aea1153feeca\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-1321d25d-720c-4a6d-b784-aea1153feeca\"\n        >\n            <span class=\"accordion__title\">\n                                Investigating the role of post-translational modifications of pathogenic molecules on microglial function.            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-1321d25d-720c-4a6d-b784-aea1153feeca\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-1321d25d-720c-4a6d-b784-aea1153feeca\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>2 Years (2023 \u2013 2025)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>PI funding (University of Luxembourg)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Masanori ITAKURA<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Amyloid-beta (A\u03b2), \u03b1-synuclein, and TDP-43 are not only known to be etiologic molecules in Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and amyotrophic lateral sclerosis (ALS), but have also been shown to undergo several post-translational modifications in response to their surrounding environment. Our project aims to investigate and compare the effects of post-translational modification (nitration, oxidation, glycation, etc.) of pathogenic molecules (A\u03b2, \u03b1-synuclein, TDP-43) on neuroinflammation and neurodegeneration. To achieve this, we will employ artificially modified or isolated molecules from brains of rodent disease models to test a) whether microglia can recognize and internalize these modified proteins, and b) whether and how these modified proteins affect the functionality of microglia (phenotypic change, cytokine production, clearance of aggregated proteins) <em>in vitro<\/em> and <em>in vivo<\/em>.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"study-of-pyroptosis-in-alzheimers-disease\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-1ac4259f-538a-4a23-9586-3a1e9639b72a\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-1ac4259f-538a-4a23-9586-3a1e9639b72a\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-1ac4259f-538a-4a23-9586-3a1e9639b72a\"\n        >\n            <span class=\"accordion__title\">\n                                Study of pyroptosis in Alzheimer\u2019s disease            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-1ac4259f-538a-4a23-9586-3a1e9639b72a\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-1ac4259f-538a-4a23-9586-3a1e9639b72a\"\n        data-bs-parent=\"[data-reference=&quot;28bfc471-f24a-416d-8f4e-75df6eac29d3&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>5 years (2022 \u2013 2027)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>PI funding (University of Luxembourg)<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Arnaud MARY<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Recent studies have uncovered neuroinflammation as a new crucial and early player in Alzheimer\u2019s disease (AD), a discovery that has provided us with new potential treatment targets to study and test therapeutically. Pathological neuroinflammation in AD leads to pyroptosis, a pro-inflammatory mode of cell death that is mediated by inflammasomes and gasdermins. While the role of neuroinflammation in the development of AD is well documented, the importance of pyroptosis in this process still needs to be clarified. Hence, our project aims to better understand the mechanisms of microglial pyroptosis in the context of AD, and to test the relevance of inflammasome-dependent pyroptosis inhibition as a new strategy to counteract AD progression.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div><\/div>\n<\/div><\/section>\n\n\n<section class=\"section section wp-block-unilux-blocks-quick-link-discover-section\">\n    <div class=\"container xl:max-w-screen-xl\">\n        \n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"discover-more\"\n    >\nDiscover more<\/h2>\n\n<ul class=\"wp-block-unilux-blocks-quick-link-discover quick-link-list\">\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/research\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Research at the LCSB                <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n\n\n\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/join-us\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Join us                <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n\n\n\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/contact\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Contact us                <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n<\/ul>\n    <\/div>\n<\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":39,"featured_media":0,"parent":680,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"Neuroinflammation","uluxPrePostTitle":"Research Group","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"field-of-interest":[],"organisation":[],"authorship":[39],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - 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