{"id":13088,"date":"2025-11-07T12:42:53","date_gmt":"2025-11-07T11:42:53","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-en\/?post_type=research-groups&#038;p=13088"},"modified":"2025-11-10T15:47:50","modified_gmt":"2025-11-10T14:47:50","slug":"research","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><!-- SecondaryNavigationMirror --><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"6bc66919-078e-4be4-8a56-a1589137e448\">\n    <nav id=\"secondary-navigation\" role=\"navigation\" aria-label=\"Secondary menu\" class=\"secondary-nav\">\n        <button class=\"secondary-nav__button btn btn-solid--primary w-full\" aria-expanded=\"false\" aria-controls=\"secondary-navigation__list\" title=\"The selected page is Research\" type=\"button\">\n            <span class=\"btn__name mr-auto\">Research<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Overview<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/research\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link isactived\" aria-current=\"page\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Research<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/publications\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Publications<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/people\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/join-us\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Join us<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<!-- end SecondaryNavigationMirror --><\/div><\/section>\n\n\n<section class=\"section  wp-block-unilux-blocks-content-card-full-width \">\n    <div class=\"container 2xl:max-w-screen-2xl\">\n        <div class=\"max-w-11\/12\">\n            <div class=\"content-card content-card--right content-card__overlay--hidden wp-block-unilux-blocks-content-card\">\n    \n<h2 class=\"content-card__heading has-text-align-left wp-block-unilux-blocks-heading\"        id=\"our-research\"\n    >\nOur research<\/h2>\n<div class=\"content-card__visual wp-block-unilux-blocks-content-card-visual-area\">\n    \n<section class=\"wp-block-unilux-blocks-image-video-wrapper\">\n    <figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--contain\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07124020\/lcsb_molecular-biophysics_dilute-and-dense-phases-formed-by-many-proteins.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07124020\/lcsb_molecular-biophysics_dilute-and-dense-phases-formed-by-many-proteins-300x175.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07124020\/lcsb_molecular-biophysics_dilute-and-dense-phases-formed-by-many-proteins-1024x597.jpg 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07124020\/lcsb_molecular-biophysics_dilute-and-dense-phases-formed-by-many-proteins-768x448.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07124020\/lcsb_molecular-biophysics_dilute-and-dense-phases-formed-by-many-proteins-1536x896.jpg 1536w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07124020\/lcsb_molecular-biophysics_dilute-and-dense-phases-formed-by-many-proteins.jpg 1954w\"\n                style=\"object-position: 47.00% 0.00%; font-family: &quot;object-fit: contain; object-position: 47.00% 0.00%;&quot;; aspect-ratio: 3\/2; object-fit: contain; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/section>\n<div class=\"wp-block-unilux-blocks-wrapper content-card__overlay\">\n<a class=\"wp-block-unilux-blocks-button-highlight-rounded bottom-left\" \n    href=\"#\"\n    target=\"_self\"\n>\n    \n<span class=\"btn-highlight-rounded__name wp-block-unilux-blocks-plain-text\"><\/span>    <span class=\"icon-rounded\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right icon--lg\"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/span>\n<\/a><\/div>\n<\/div><div class=\"content-card__body  wp-block-unilux-blocks-content-card-free-area\">\n    \n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"mechanisms-driving-and-inhibiting-solid-phase-transitions-of-proteins\"\n    >\nMechanisms driving and inhibiting solid phase transitions of proteins<\/h2>\n\n<p>Proteins are not isolated entities, but rather interact dynamically with each other and with molecular chaperones. This interplay is of particular significance for intrinsically disordered proteins (IDPs), which have been observed to form nanoclusters, biomolecular condensates, and \u2013 if unchecked \u2013 irreversible aggregates linked to neurodegeneration. Notwithstanding the clinical importance of these processes, the molecular rules that govern the transition from dynamic protein assemblies to hardened deposits remain poorly understood.<\/p>\n\n<p>The primary focus of this group is the investigation of the regulatory mechanisms of protein assembly and aggregation by molecular chaperones, with a particular emphasis on small heat shock proteins (sHSPs). The group investigates how their unique binding modes and dynamic oligomerisation suppress the formation of toxic states and influence the material properties of condensates. In order to achieve this objective, advanced microfluidic and biophysical methods are developed and applied, in combination with quantitative fluorescence microscopy and other imaging approaches. These techniques enable the quantification of protein\u2013chaperone interactions in complex mixtures, the resolution of heterogeneous clusters, and the tracking of structural transitions across multiple scales. The objective is to provide a mechanistic understanding of how chaperone systems safeguard the proteome by bridging molecular biophysics with disease biology, and to elucidate the underlying mechanisms by which such failure contributes to the onset of sporadic neurodegenerative disorders, with a view to inspiring novel therapeutic strategies.<\/p>\n\n<p><em>Image: A schematic summary of the dilute and dense phases formed by many proteins. Phase separation produces dense droplets where aggregation, as shown for FUS, is promoted at the phase interface, while the dilute phase contains freely diffusing monomers, oligomers, fixed-size- or percolation-clusters. Images rendered using FUS (AF-P35637-F1) and FUS fibril (PDB: 7VQQ) structures.<\/em><\/p>\n<\/div><\/div>        <\/div>\n    <\/div>\n<\/section>\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"our-research-projects\"\n    >\nOur research projects<\/h2>\n\n\n\n<p>This section introduces current projects of the Molecular Biophysics group. Our research projects explore how molecular chaperones regulate protein assembly, linking classical aggregation kinetics with emerging concepts of phase separation and condensate biology.<\/p>\n<\/div><\/section>\n\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<div class=\"wp-block-unilux-blocks-accordion accordion accordion--theme accordion-standard\" data-reference=\"dbe369d5-5dcf-44d1-8bba-b940c728f7bc\" data-accordion-type=\"standard\"><div class=\"accordion__item  wp-block-unilux-blocks-accordion-item\">\n    <h3 class=\"accordion__header\"\n                    id=\"bridging-the-understanding-of-protein-aggregation-and-phase-separation-by-chaperone-mediated-assembly\"\n        >\n        <button\n            type=\"button\"\n            id=\"accordion-labelledby-7fb28b21-5667-4543-9fd5-93f3fb9d8a56\"\n            class=\"accordion__button collapsed\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-panel-7fb28b21-5667-4543-9fd5-93f3fb9d8a56\"\n            data-bs-toggle=\"collapse\"\n            data-bs-target=\"#accordion-panel-7fb28b21-5667-4543-9fd5-93f3fb9d8a56\"\n        >\n            <span class=\"accordion__title\">\n                                Bridging the understanding of protein aggregation and phase separation by chaperone-mediated assembly            <\/span>\n\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-down \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\"><\/use><\/svg>        <\/button>\n    <\/h3>\n    <div id=\"accordion-panel-7fb28b21-5667-4543-9fd5-93f3fb9d8a56\"\n        class=\"accordion__collapse collapse\"\n        aria-labelledby=\"accordion-labelledby-7fb28b21-5667-4543-9fd5-93f3fb9d8a56\"\n        data-bs-parent=\"[data-reference=&quot;dbe369d5-5dcf-44d1-8bba-b940c728f7bc&quot;]\"\n    >\n        <div class=\"accordion__body \">\n            \n<ul class=\"wp-block-unilux-blocks-highlighted-list list-highlighted list-highlighted--course\"><li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"duration\"\n    >\nDuration:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"funding-source\"\n    >\nFunding source:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>LCSB<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"researchers\"\n    >\nResearchers:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\nPartners:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"description\"\n    >\nDescription:<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p>Protein aggregation underlies many neurodegenerative diseases, yet classical models of nucleation, fibril elongation, and secondary nucleation do not involve the heterogeneous protein states observed in cells. Increasing evidence points to nanometre-sized percolation clusters and liquid phase separation as potential precursors of aggregation. These assemblies are dynamic, heterogeneous, and potentially reversible, but can also convert into solid-like, pathological states. How such intermediate states are connected to classical aggregation kinetics, and how they are regulated by molecular chaperones, is largely unknown.<\/p>\n\n<p>This project investigates how small heat shock proteins (sHSPs) control the assembly of intrinsically disordered proteins (IDPs) into clusters and condensates, and how they suppress transitions into toxic oligomers and hardened aggregates. We will dissect how dynamic sHSP oligomers engage multiple binding sites on IDPs, how they alter the surface tension and wetting behaviour of condensates, and how these interactions remodel kinetic pathways of assembly. To achieve this, we develop microfluidic diffusional sizing and electrophoresis to quantify binding equilibria in heterogeneous mixtures, employ droplet-based assays to measure wetting angles, condensate material states, and chaperone partitioning, and use Thioflavin T (ThT) fluorescence to monitor the onset and kinetics of amyloid fibril formation. Complementary fluorescence imaging will track structural transitions across scales, from nanoclusters to micrometre-sized droplets. By linking percolation cluster formation, condensate dynamics, and classical aggregation pathways, we aim to define how sHSPs safeguard the proteome and why their decline predisposes cells to sporadic neurodegeneration.<\/p>\n<\/div><\/div><\/li>\n\n<li class=\"list-highlighted__item  items-start wp-block-unilux-blocks-highlighted-list-item\">\n    <header class=\"list-highlighted__header wp-block-unilux-blocks-highlighted-list-item-header\">\n    \n<h4 class=\"title text-18 font-bold has-text-align-left wp-block-unilux-blocks-heading\"        id=\"project-details-pdf\"\n    >\nProject details (PDF):<\/h4>\n<div class=\"wp-block-unilux-blocks-bigtext\">\n    <span>\n        \n    <\/span>\n<\/div><\/header><div class=\"list-highlighted__body wp-block-unilux-blocks-highlighted-list-item-body\">\n    <div class=\"wp-block-unilux-blocks-highlighted-list-item-free-content-area\">\n    \n<p><\/p>\n<\/div><\/div><\/li><\/ul>\n        <\/div>\n    <\/div>\n<\/div><\/div>\n<\/div><\/section>\n\n\n<section class=\"section section wp-block-unilux-blocks-quick-link-discover-section \">\n    <div class=\"container xl:max-w-screen-xl\">\n        \n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"discover-more\"\n    >\nDiscover more<\/h2>\n\n<ul class=\"wp-block-unilux-blocks-quick-link-discover quick-link-list\">\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/research\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Research at the LCSB                 <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n\n\n\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/join-us\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Join us                <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n\n\n\n<li class=\"wp-block-unilux-blocks-quick-link-discover-item\">\n    <a\n                    href=\"https:\/\/www.uni.lu\/lcsb-en\/contact\/\"\n                    class=\"quick-link\"\n            target=\"\"\n    >\n            <span class=\"quick-link__container\">\n                <span class=\"quick-link__text\">\n                    Contact us                 <\/span>\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>            <\/span>\n    <\/a>\n<\/li>\n<\/ul>\n    <\/div>\n<\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":56,"featured_media":0,"parent":13079,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"Molecular Biophysics","uluxPrePostTitle":"Research Group","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"field-of-interest":[290],"organisation":[],"authorship":[56],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Molecular Biophysics - LCSB research group I University of Luxembourg<\/title>\n<meta name=\"description\" content=\"Proteins are not isolated entities, but rather interact dynamically with each other and with molecular chaperones. 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