{"id":13079,"date":"2025-11-07T12:35:04","date_gmt":"2025-11-07T11:35:04","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-en\/?post_type=research-groups&#038;p=13079"},"modified":"2026-01-15T12:41:14","modified_gmt":"2026-01-15T11:41:14","slug":"molecular-biophysics","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/","title":{"rendered":"Molecular Biophysics"},"content":{"rendered":"<div class=\"section py-0 static\"><div class=\"section py-0 section wp-block-unilux-blocks-navigation-and-hero py-0\">\n    \n<div class=\"wp-block-unilux-blocks-wrapper container xl:max-w-screen-xl\"><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"6bc66919-078e-4be4-8a56-a1589137e448\">\n    <nav\n        id=\"secondary-navigation\"\n        role=\"navigation\"\n        aria-label=\"Secondary menu\"\n        class=\"secondary-nav\"\n    >\n        <button\n            class=\"secondary-nav__button btn btn-solid--primary w-full\"\n            aria-expanded=\"false\"\n            aria-controls=\"secondary-navigation__list\"\n            title=\"The selected page is Overview\"\n            type=\"button\"\n        >\n            <span class=\"btn__name mr-auto\">Overview<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link isactived\"\n        aria-current=\"page\"    >\n        <svg 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href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/publications\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Publications<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/people\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/join-us\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Join us<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<\/div>\n\n<div class=\"wp-block-unilux-blocks-wrapper max-w-screen-3xl mx-auto section py-0\">\n<section class=\"section no-padding-y wp-block-unilux-blocks-hero\">\n    <div class=\"hero hero--2 hero--overlay-top \">\n        \n<header class=\"wp-block-unilux-blocks-wrapper hero__header\">\n<div class=\"wp-block-unilux-blocks-wrapper hero__container\">\n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\"><\/span>\n\n\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"molecular-biophysics-of-chaperone-mediated-protein-assembly\"\n    >\nMolecular biophysics of chaperone-mediated protein assembly<\/h1>\n<\/div>\n<\/header>\n<figure class=\"wp-block-dev4-reusable-blocks-image hero__visual object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120121\/LCSB_Molecular-Biophysics-group.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120121\/LCSB_Molecular-Biophysics-group-300x169.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120121\/LCSB_Molecular-Biophysics-group-1024x578.png 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120121\/LCSB_Molecular-Biophysics-group-768x433.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120121\/LCSB_Molecular-Biophysics-group.png 1078w\"\n                style=\"object-position: 44.00% 51.00%; font-family: &quot;object-fit: cover; object-position: 44.00% 51.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>\n<div class=\"wp-block-unilux-blocks-wrapper hero__body\">\n<div class=\"wp-block-unilux-blocks-wrapper hero__container\">\n<p class=\"wp-block-unilux-blocks-plain-text\">The Molecular Biophysics Group, led by Dr. Tom Scheidt, uses microfluidic and biophysical methods to explore how molecular chaperones regulate protein assembly and aggregation. <\/p>\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list\">\n\n<\/ul>\n<\/div>\n<\/div>\n    <\/div>\n<\/section><\/div>\n<\/div>\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"a-glimpse-into-our-research\"\n    >\nA glimpse into our research<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"bridging-scales-from-molecules-to-neurodegeneration\"\n    >\nBridging scales: from molecules to neurodegeneration<\/h3>\n\n\n\n<p>We use microfluidic and biophysical techniques to bridge the gap between classical protein aggregation kinetics and the emerging concept of phase separation and nanometre-sized cluster formation. Our research focuses on the regulation of intrinsically disordered proteins, oligomer formation, and the conversion of condensates into pathological aggregates in neurodegeneration by molecular chaperones, particularly small heat shock proteins.<\/p>\n\n\n\n<ul class=\"wp-block-unilux-blocks-quick-link-underline\">\n    \n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/research\/\/\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">Research<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/a>\n<\/li>\n\n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/publications\/\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">Publications<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/a>\n<\/li>\n\n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/molecular-biophysics\/people\/\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">People<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/a>\n<\/li>\n<\/ul><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--contain\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120441\/Small-heat-shock-proteins-modulate-IDP-morphology-.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120441\/Small-heat-shock-proteins-modulate-IDP-morphology--300x237.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120441\/Small-heat-shock-proteins-modulate-IDP-morphology--1024x810.png 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120441\/Small-heat-shock-proteins-modulate-IDP-morphology--768x608.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/11\/07120441\/Small-heat-shock-proteins-modulate-IDP-morphology-.png 1475w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: contain; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 4\/3; object-fit: contain; width: 100%;\"\n        loading=\"lazy\"\n\/>            <p class=\"wp-block-dev4-reusable-blocks-image-caption\">\n            Small heat shock proteins modulate IDP morphology through dynamic, polydisperse oligomers that bind diverse targets via subunit exchange        <\/p>\n    <\/figure><\/div>\n<\/div>\n<\/div><\/section>\n\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"this-research-group-is-part-of\"\n    >\nThis research group is part of<\/h2>\n\n\n\n<ul class=\"wp-block-unilux-blocks-button-list-v2\">\n<li class=\"wp-block-unilux-blocks-button-list-item-v2\"><a class=\"quick-link\" href=\"https:\/\/www.uni.lu\/lcsb-en\/\" target=\"\" role=\"link\" rel=\"noopener\" tabindex=\"0\"><span class=\"quick-link__container\">\n<div class=\"wp-block-unilux-blocks-block-inserter quick-link__img\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"Luxembourg Centre for Systems Biomedicine Logo\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/uni-centre-lcsb-no-baseline.svg\"\n                    style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 1\/1; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/div>\n\n\n\n<span class=\"quick-link__name wp-block-unilux-blocks-plain-text\">Luxembourg Centre for Systems Biomedicine (LCSB)<\/span>\n\n<svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/span><\/a><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-lg\"><\/div><\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The Molecular Biophysics Group, led by Dr. Tom Scheidt, uses microfluidic and biophysical methods to explore how molecular chaperones regulate protein assembly and aggregation. The group will start in January 2026.<\/p>\n","protected":false},"author":56,"featured_media":13082,"parent":0,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"Molecular Biophysics","uluxPrePostTitle":"Research Group","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"field-of-interest":[290],"organisation":[],"authorship":[56],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Molecular Biophysics - LCSB research group I University of Luxembourg<\/title>\n<meta name=\"description\" content=\"The Molecular Biophysics Group, led by Dr. Tom Scheidt, uses microfluidic and biophysical methods to explore how molecular chaperones regulate protein assembly and aggregation. 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