{"id":2095,"date":"2023-09-07T14:38:32","date_gmt":"2023-09-07T12:38:32","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-en\/?post_type=news&#038;p=2095"},"modified":"2024-01-04T08:49:05","modified_gmt":"2024-01-04T07:49:05","slug":"nature-genetics-epilepsy","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/lcsb-en\/news\/nature-genetics-epilepsy\/","title":{"rendered":"LCSB researchers contribute to largest genetic study of epilepsy to date"},"content":{"rendered":"\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<p>The largest genetic study of its kind, coordinated by the <a href=\"https:\/\/www.ilae.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">International League Against Epilepsy (ILAE)<\/a>, including scientists from the ILAE Consortium on Complex Epilepsies of the Genetics Commission amongst which several scientists of the Luxembourg Centre for Systems Biomedicine (LCSB), has discovered specific changes in our DNA that increase the risk of developing epilepsy.<\/p>\n\n\n\n<p>The research,&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s41588-023-01485-w\" target=\"_blank\" rel=\"noreferrer noopener\">published recently in&nbsp;<em>Nature Genetics<\/em><\/a><em>,&nbsp;<\/em>greatly advances our knowledge of why epilepsy develops and may inform the development of new treatments for the condition.<\/p>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"understanding-the-genetic-underpinnings-of-epilepsy\"\n    >\nUnderstanding the genetic underpinnings of epilepsy<\/h2>\n\n\n\n<p>Epilepsy, a prevalent neurological condition encompassing various distinct types, is known for its genetic predisposition and to sometimes run in families. In this recent study, scientists conducted a comparative analysis of the genetic profiles of nearly 30,000 individuals diagnosed with epilepsy against those of 52,500 individuals without the condition. This study pinpointed specific regions within our DNA that could play a role in the development of epilepsy.<\/p>\n\n\n\n<p>\u201cManaging and harmonising all genetic and phenotypic data of such a large data set is crucial for the success of a study,\u201d explains Dr Roland Krause, one of the main researchers of the study at <a href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/bioinformatics-core\/\" target=\"_blank\" rel=\"noreferrer noopener\">LCSB\u2019s Bioinformatics Core<\/a>. \u201cThis is where the long-standing expertise in biomedical data management comes into play.\u201d<\/p>\n\n\n\n<p>The researchers identified 26 distinct regions in our DNA that seem to be involved in epilepsy. This included 19 which are specific to a particular type of epilepsy called \u2018genetic generalized epilepsy\u2019 (GGE). They were also able to identify 29 genes that are probably contributing to epilepsy within these DNA regions.<\/p>\n\n\n\n<p>\u201cWe were also interested to pinpoint genetic differences between the different types of epilepsy,\u201d adds Dr Patrick May, responsible for genetic analysis at the LCSB. \u201cTogether with our team and the international collaborators we were able to show significant differences within a specific sub-type on \u2018generalised\u2019 epilepsies and genetic overlap with other brain diseases. This opens new avenues for precision medicine.\u201d The results also suggested that proteins that carry electrical impulse across the gaps between neurons in our brain make up some of the risk for generalised forms of epilepsy.<\/p>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"paving-the-way-for-future-treatment-strategies\"\n    >\nPaving the way for future treatment strategies<\/h2>\n\n\n\n<p>\u201cGaining a better understanding of the genetic underpinnings of epilepsy is key to developing new therapeutic options and consequently a better quality of life for the over 50 million people globally living with epilepsy,\u201d said Professor Gianpiero Cavalleri, Professor of Human Genetics at RCSI School of Pharmacy and Biomolecular Science, Deputy Director of the SFI FutureNeuro Research Centre and member of the ILAE Consortium on Complex Epilepsies.<\/p>\n\n\n\n<p>\u201cThe discoveries we report on here could only be achieved through international collaboration,\u00a0on a global scale. We are proud of how the global community of scientists working to better understand the genetics of the epilepsies have pooled resources and collaborated effectively, for the benefit of people impacted by condition,\u201d commented Professor Cavalleri.<\/p>\n\n\n\n<p>The researchers also showed that many of the current medications work by targeting the same epilepsy risk genes that were highlighted in this study. However, based on their data, the researchers were able to propose some potentially effective alternative drugs. These will need to be clinically tested for use in epilepsy as they are normally used for other conditions, but they are known to target some of the other epilepsy risk genes uncovered.<\/p>\n\n\n\n<p>\u201cThis identification of epilepsy-associated genetic changes will allow us to improve diagnosis and classification of different epilepsy subtypes. This in turn, will guide clinicians in selecting the most beneficial treatment strategies, minimising seizures,\u201d said Professor Colin Doherty, Consultant Neurologist, St James\u2019s Hospital, Co-author and Clinical Investigator at the SFI FutureNeuro Centre, and member of the Irish Epilepsy League.<\/p>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"global-collaboration-a-catalyst-for-epilepsy-research\"\n    >\nGlobal collaboration: a catalyst for epilepsy research<\/h2>\n\n\n\n<p>Over 150 researchers, based across Europe, Australia, Asia, South America and North America, carried out the research. They worked together as part of the ILAE Consortium on Complex Epilepsies. The ILAE Consortium was formed by researchers in 2010, recognising that the complexity of genetic and environmental factors underlying epilepsy would require research across massive datasets, and therefore unprecedented collaboration on an international scale. The LCSB is the main data hub for the ILAE Genetics and Genomics Subgroups, coordinating the data management and providing the analytical infrastructure that makes such large-scale collaborative studies possible.<\/p>\n\n\n\n<p>\u201cUndertaking such a comprehensive study is a remarkable achievement [\u2026] The challenge now is to translate the findings of this research to improve the lives of people with epilepsy,\u201d concluded Professor Cavalleri.<\/p>\n\n\n\n<p>\u201cWith this study, we have bookmarked parts of our genome that should be the major focus of future epilepsy research. It will form the basis for further work looking at the molecular pathways involved in seizure generation, neuronal dysfunction and altered brain activity,\u201d said Professor Samuel Berkovic, University of Melbourne.<\/p>\n\n\n\n<p>&#8220;This is a major milestone for the ILAE Consortium on Complex Epilepsies, demonstrating what can be achieved when scientists openly collaborate and share data from across the world. The outputs are wide-reaching and applicable to epilepsy patients globally,\u201d said Professor Helen Cross, President of the International League Against Epilepsy.<\/p>\n\n\n\n<p>Guided by the ILAE vision of a world in which no person\u2019s life is limited by epilepsy, the driving principle behind the ILAE Consortium is that through collaboration and synergy, researchers will make more progress towards fully understanding the inherited components of epilepsy than can be realized by individual groups.<\/p>\n\n\n\n<p><strong>More information:<\/strong>&nbsp;GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture,&nbsp;<em>Nature Genetics<\/em>&nbsp;(2023).&nbsp;<a href=\"https:\/\/dx.doi.org\/10.1038\/s41588-023-01485-w\" target=\"_blank\" rel=\"noreferrer noopener\">DOI: 10.1038\/s41588-023-01485-w<\/a><\/p>\n\n\n\n<p>Photo by <a href=\"https:\/\/unsplash.com\/@sangharsh_l?utm_source=unsplash&amp;utm_medium=referral&amp;utm_content=creditCopyText\">Sangharsh Lohakare<\/a> on <a href=\"https:\/\/unsplash.com\/photos\/Iy7QyzOs1bo?utm_source=unsplash&amp;utm_medium=referral&amp;utm_content=creditCopyText\">Unsplash<\/a><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"<p>The largest genetic study of its kind, coordinated by the International League Against Epilepsy (ILAE), including scientists from the ILAE Consortium on Complex Epilepsies of the Genetics Commission amongst which several scientists of the Luxembourg Centre for Systems Biomedicine (LCSB), has discovered specific changes in our DNA that increase the risk of developing epilepsy.<\/p>\n","protected":false},"author":56,"featured_media":2101,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[4],"news-topic":[19],"organisation":[202],"authorship":[56],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - 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