Research Group Neuroinflammation

Publications

  1. Galgani A, Mary A, Lombardo F, Martini N, Scotto M, Tognoni G, Siciliano G, Ceravolo R, Giorgi FS, Heneka MT. Locus coeruleus integrity correlates with plasma soluble Axl levels in Alzheimer’s disease patients. Alzheimers Dement. 2025 Jul;21(7):e70434. https://www.doi.org/10.1002/alz.70434. PMID: 40596706; PMCID: PMC12213453.
  2. Haase L, Belkacemi A, Neises L, Kiweler N, Wesely C, Huchzermeier R, Bozic M, Khakdan A, Sánchez M, Mary A, Sachs N, Winter H, Glaab E, Heneka MT, van der Vorst EP, Mittelbronn M, Meiser J, Schneider JG. Modulation of the Acod1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes. J Clin Invest. 2025 Jun 12:e182472. https://www.doi.org/10.1172/JCI182472. Epub ahead of print. PMID: 40504626.
  3. Villacampa N, Sarlus H, Martorell P, Bhalla K, Castro-Gomez S, Vieira-Saecker A, Slutzkin I, Händler K, Venegas C, McManus R, Ulas T, Beyer M, Segal E, Heneka MT. Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease. ASN Neuro. 2025;17(1):2506406. https://www.doi.org/10.1080/17590914.2025.2506406. Epub 2025 May 19. PMID: 40387894; PMCID: PMC12140498.
  4. Baker V, Budinger D, Riechers SP, Heneka MT. Protocol for observing tunneling nanotube formation and function in both fixed and live primary mouse neurons and microglia coculture system. STAR Protoc. 2025 Jun 20;6(2):103723. https://www.doi.org/10.1016/j.xpro.2025.103723. Epub 2025 Apr 3. PMID: 40184246; PMCID: PMC12002979.
  5. Heneka MT, van der Flier WM, Jessen F, Hoozemanns J, Thal DR, Boche D, Brosseron F, Teunissen C, Zetterberg H, Jacobs AH, Edison P, Ramirez A, Cruchaga C, Lambert JC, Laza AR, Sanchez-Mut JV, Fischer A, Castro-Gomez S, Stein TD, Kleineidam L, Wagner M, Neher JJ, Cunningham C, Singhrao SK, Prinz M, Glass CK, Schlachetzki JCM, Butovsky O, Kleemann K, De Jaeger PL, Scheiblich H, Brown GC, Landreth G, Moutinho M, Grutzendler J, Gomez-Nicola D, McManus RM, Andreasson K, Ising C, Karabag D, Baker DJ, Liddelow SA, Verkhratsky A, Tansey M, Monsonego A, Aigner L, Dorothée G, Nave KA, Simons M, Constantin G, Rosenzweig N, Pascual A, Petzold GC, Kipnis J, Venegas C, Colonna M, Walter J, Tenner AJ, O’Banion MK, Steinert JR, Feinstein DL, Sastre M, Bhaskar K, Hong S, Schafer DP, Golde T, Ransohoff RM, Morgan D, Breitner J, Mancuso R, Riechers SP. Neuroinflammation in Alzheimer disease. Nat Rev Immunol. 2025 May;25(5):321-352. https://www.doi.org/10.1038/s41577-024-01104-7. Epub 2024 Dec 9. PMID: 39653749.
  6. Tastan B, Heneka MT. The impact of neuroinflammation on neuronal integrity. Immunol Rev. 2024 Oct;327(1):8-32. https://www.doi.org/10.1111/imr.13419. Epub 2024 Oct 29. PMID: 39470038.
  7. Budinger D, Baker V, Heneka MT. Tunneling Nanotubes in the Brain. Results Probl Cell Differ. 2024;73:203-227. https://www.doi.org/10.1007/978-3-031-62036-2_10. PMID: 39242381.
  8. Botella Lucena P, Heneka MT. Inflammatory aspects of Alzheimer’s disease. Acta Neuropathol. 2024 Aug 28;148(1):31. https://www.doi.org/10.1007/s00401-024-02790-2. PMID: 39196440.
  9. Owona BA, Mary A, Messi AN, Ravichandran KA, Mbing JN, Pegnyemb E, Moundipa PF, Heneka MT. Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Mol Neurobiol. 2025 Feb;62(2):1605-1619. https://www.doi.org/10.1007/s12035-024-04365-4. Epub 2024 Jul 16. PMID: 39012444.
  10. Mary A, Mancuso R, Heneka MT. Immune Activation in Alzheimer Disease. Annu Rev Immunol. 2024 Jun;42(1):585-613. https://www.doi.org/10.1146/annurev-immunol-101921-035222. Epub 2024 Jun 14. PMID: 38424470.
  11. Talavera Andújar B, Mary A, Venegas C, Cheng T, Zaslavsky L, Bolton EE, Heneka MT, Schymanski EL. Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer’s Disease Patients? Environ Sci Technol. 2024 Mar 5;58(9):4181-4192. https://www.doi.org/10.1021/acs.est.3c10490. Epub 2024 Feb 19. PMID: 38373301; PMCID: PMC10919072.
  12. Dadwal S, Heneka MT. Microglia heterogeneity in health and disease. FEBS Open Bio. 2024 Feb;14(2):217-229. https://www.doi.org/10.1002/2211-5463.13735. Epub 2023 Nov 16. PMID: 37945346; PMCID: PMC10839410.

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