Interdisciplinary Centre Luxembourg Centre for Systems Biomedicine (LCSB)

Metabolomics and Lipidomics Platform

Researchers working in the Metabolomics and Lipidomics Platform

The Metabolomics and Lipidomics Platform is specialised in developing and applying mass spectrometry-based comprehensive analysis methods of small molecules in complex biological matrices. The platform supports a wide range of cutting-edge metabolomic and lipidomic approaches for several sample types, including

  • mammalian cells
  • bacteria, yeast
  • body fluids (e.g., cerebrospinal fluid, plasma, serum, urine)
  • stool
  • soft tissues (e.g., brain, liver, lung, heart, kidney)
  • others (e.g., dried blood spots)

To address the needs of researchers in this fast-changing field, the Metabolomics and Lipidomics Platform is continuously developing new analytical (targeted/untargeted) and tailored methods to address cutting-edge biological and biomedical questions. The platform also provides a comprehensive set of tools for a reliable data analysis based on a statistical evaluation. 

The highly competitive price structure enables researchers in Luxembourg to obtain fast, accurate and complete data generation in order to successfully pursue their research goals.

Equipment

Liquid Chromatography – Mass Spectrometry

  • Thermo Vanquish UHPLC – Thermo Orbitrap Exploris 240 MS

    Thermo Vanquish UHPLC – Thermo Orbitrap Exploris 240 MS

  • Thermo Vanquish UHPLC – Thermo Q Exactive HF MS

    Thermo Vanquish UHPLC – Thermo Q Exactive HF MS

  • SCIEX Exion LC – SCIEX Triple Quad 7500 MS

    SCIEX Exion LC – SCIEX Triple Quad 7500 MS

  • Agilent 1290 LC–Agilent 6560 MS

    Agilent 1290 LC–Agilent 6560 MS

Gas Chromatography – Mass Spectrometry

  • Agilent 8890 GC–Agilent 5977B MS

    Agilent 8890 GC–Agilent 5977B MS

  • Agilent 7890B GC–Agilent 5977A MS

    Agilent 7890B GC–Agilent 5977A MS

Ion Chromatography – Mass Spectrometry

  • Dionex ICS-6000 – Thermo Q Exactive MS

    Dionex ICS-6000 – Thermo Q Exactive MS

Services

  • Quantitative LC-MS, GC-MS and IC-MS analyses: Metabolic profiling (Relative or absolute quantification of target compounds)
  • Untargeted LC-MS and GC-MS analyses (biomarker discovery, hypothesis-free approach): Discovery-based relative quantification of known and unknown compounds
  • 13C tracing analyses (stable isotope-assisted metabolomics): Quantification of intracellular fluxes, metabolic flux analysis, rel. pathway activities, qualitative changes in pathway contributions
  • Medium analyses – secretion and uptake rates: Precise absolute quantification of selected medium components
  • Structure elucidation: Accurate mass, isotopic composition, sum formula, interpretation of mass spectra

Method development, method transfer and method validation

Limited access: advanced MS users only @ LCSB

For beginner to professional level users to conduct Metabolomics experiments

Vacuum concentration, freeze drying, nitrogen blowdown, liquid-liquid extraction, solid-phase extraction, derivatization, and more

People

Contact

For any inquiries or questions regarding methodologies, instrumentation, sample processing, or prices, we invite you to contact us via email or phone.

Email: LCSB-metabolomics [at] uni.lu
Phone: (+352) 466 644 6650