Metabolomics and Lipidomics Platform
The Metabolomics and Lipidomics Platform is specialised in developing and applying mass spectrometry-based comprehensive analysis methods of small molecules in complex biological matrices. The platform supports a wide range of cutting-edge metabolomic and lipidomic approaches for several sample types, including
- mammalian cells
- bacteria, yeast
- body fluids (e.g., cerebrospinal fluid, plasma, serum, urine)
- stool
- soft tissues (e.g., brain, liver, lung, heart, kidney)
- others (e.g., dried blood spots)
To address the needs of researchers in this fast-changing field, the Metabolomics and Lipidomics Platform is continuously developing new analytical (targeted/untargeted) and tailored methods to address cutting-edge biological and biomedical questions. The platform also provides a comprehensive set of tools for a reliable data analysis based on a statistical evaluation.
The highly competitive price structure enables researchers in Luxembourg to obtain fast, accurate and complete data generation in order to successfully pursue their research goals.
Services
- Quantitative LC-MS, GC-MS and IC-MS analyses: Metabolic profiling (Relative or absolute quantification of target compounds)
- Untargeted LC-MS and GC-MS analyses (biomarker discovery, hypothesis-free approach): Discovery-based relative quantification of known and unknown compounds
- 13C tracing analyses (stable isotope-assisted metabolomics): Quantification of intracellular fluxes, metabolic flux analysis, rel. pathway activities, qualitative changes in pathway contributions
- Medium analyses – secretion and uptake rates: Precise absolute quantification of selected medium components
- Structure elucidation: Accurate mass, isotopic composition, sum formula, interpretation of mass spectra
Method development, method transfer and method validation
Limited access: advanced MS users only @ LCSB
For beginner to professional level users to conduct Metabolomics experiments
Vacuum concentration, freeze drying, nitrogen blowdown, liquid-liquid extraction, solid-phase extraction, derivatization, and more
Equipment
Liquid Chromatography – Mass Spectrometry
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Thermo Vanquish UHPLC – Thermo Orbitrap Exploris 240 MS
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Thermo Vanquish UHPLC – Thermo Q Exactive HF MS
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SCIEX Exion LC – SCIEX Triple Quad 7500 MS
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Agilent 1290 LC–Agilent 6560 MS
Gas Chromatography – Mass Spectrometry
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Agilent 8890 GC–Agilent 5977B MS
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Agilent 7890B GC–Agilent 5977A MS
Ion Chromatography – Mass Spectrometry
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Dionex ICS-6000 – Thermo Q Exactive MS
People
Contact
For any inquiries or questions regarding methodologies, instrumentation, sample processing, or prices, we invite you to contact us via email or phone.