{"id":309,"date":"2020-05-20T07:23:17","date_gmt":"2020-05-20T07:23:17","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/fstm-fr\/news\/canbio-programme-training-phd-students-in-cancer-biology\/"},"modified":"2020-05-20T07:23:17","modified_gmt":"2020-05-20T07:23:17","slug":"canbio-programme-training-phd-students-in-cancer-biology","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/fstm-fr\/news\/canbio-programme-training-phd-students-in-cancer-biology\/","title":{"rendered":"CANBIO programme: training PhD students in cancer biology"},"content":{"rendered":"<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><p>In the frame of the Cancer Biology \u201cCANBIO\u201d doctoral training unit launched in 2016 by the University of Luxembourg, the Luxembourg Institute of Health (LIH) and the Laboratoire National de Sant\u00e9 (LNS), the first virtual PhD defence and online training module took place at the time of COVID-19.<\/p><p>Despite recent progress in drug development, cancer is incurable in many instances and remains one of the main challenges of modern-day medicine. One of the factors that contribute to its insidiousness is the ability to circumvent surveillance by the body\u2019s immune system and to develop drug resistance mechanisms. The understanding of these \u201cescape\u201d strategies is therefore crucial in the fight against cancer. In this context, the University of Luxembourg, the <a href=\"https:\/\/www.lih.lu\/\" target=\"_blank\" title=\"\" rel=\"noopener\">Luxembourg Institute of Health (LIH)<\/a> and the <a href=\"https:\/\/lns.lu\/\" target=\"_blank\" title=\"\" rel=\"noopener\">Laboratoire National de Sant\u00e9 (LNS)<\/a> launched the Cancer Biology \u201cCANBIO\u201d PhD training programme in 2016, with the aim of providing state-of-the-art training in cancer biology to young scientists, thereby leading to the development of more effective therapies and fostering translational research.<\/p><p><strong>First PhD defence under CANBIO <\/strong><\/p><p>On 27 April 2020, doctoral candidate <a href=\"https:\/\/wwwfr.uni.lu\/recherche\/fstm\/dlsm\/people\/ines_kozar\" target=\"_self\" title=\"\" rel=\"noopener\">Ines Kozar<\/a> defended her thesis \u201cFrom drug resistance mechanisms to miRNA function in melanoma\u201d. Supervised by <a href=\"https:\/\/wwwfr.uni.lu\/recherche\/fstm\/dlsm\/people\/stephanie_kreis\" target=\"_self\" title=\"\" rel=\"noopener\">Prof. Stephanie Kreis<\/a> from the <a href=\"https:\/\/wwwfr.uni.lu\/recherche\/fstm\/dlsm\" target=\"_self\" title=\"\" rel=\"noopener\">Department of Life Sciences and Medicine (DLSM)<\/a> at the University of Luxembourg, her work focuses on novel approaches to tackle drug resistance in melanoma, an aggressive skin cancer originating from the uncontrolled proliferation of pigment-producing melanocytes. Dr. Kozar identified a new set of inhibitors that showed promising results for the treatment of late-stage melanoma patients. In addition, she detected a series of genes and microRNAs that were expressed in different patterns in drug-resistant compared to drug-sensitive cells, thus suggesting a role for miRNAs in the transition from sensitivity to tolerance.<\/p><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--contain\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/20\/2023\/07\/ines.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/20\/2023\/07\/ines-300x199.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/20\/2023\/07\/ines.jpg 500w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: contain; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 3\/2; object-fit: contain; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><p>\u201cWe are very proud of Ines\u2019 work and achievements. She has been the first CANBIO student to graduate, having already contributed to 6 peer-reviewed publications plus an additional one currently under review. On top of this, she has also been the first candidate to have defended her thesis completely remotely via Webex! Indeed, high-quality cancer research \u201cmade in Luxembourg\u201d carries on despite the current COVID-19 situation, since cancer does not stop and millions of patients are still in urgent need of new therapies\u201d, states Prof. St\u00e9phanie Kreis.<\/p><p><strong>First online training module<\/strong><\/p><p>In addition to the project-based training, the CANBIO programme has implemented a specific training curriculum which consisted of three main modules, running between October 2019 and May 2020. After the two modules \u201cComputational approaches to disease monitoring and network analysis\u201d in October 2019 and \u201cInduced Escape Mechanisms\u201d in February 2020, the third module \u201cIntrinsic escape mechanisms\u201d was delivered entirely remotely in April-May 2020. It covered the basic principles of tumorigenesis and therapy, preclinical models, tumour heterogeneity in relation to therapeutic principles, as well as invasion and metastasis.<\/p><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--contain\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/20\/2023\/07\/canbio.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/20\/2023\/07\/canbio-300x200.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/20\/2023\/07\/canbio.png 500w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: contain; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 3\/2; object-fit: contain; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><p>\u201cCANBIO concentrates on the mechanisms enabling cancer cells to constantly adapt to their environments and survive therapeutic treatments. Unfortunately, these molecular changes do not stop with the COVID-19 pandemic, and so we too decided to adapt to the current situation in order to keep delivering quality cancer training to our students, providing them with the knowledge and skills they need to eventually develop novel solutions to the pressing issue of tumour escape\u201d, says <a href=\"https:\/\/www.lih.lu\/page\/prof-simone-niclou\" target=\"_blank\" title=\"\" rel=\"noopener\">Prof. Simone Niclou<\/a>, Director of the\u00a0<a href=\"https:\/\/www.lih.lu\/page\/departments\/donc-department-of-oncology-789\" target=\"_blank\" title=\"\" rel=\"noopener\">Department of Oncology (DONC)<\/a>\u00a0at LIH and CANBIO coordinator. \u201cOur PhD candidates have once again proved their commitment to their scientific training and their flexibility, which was key in ensuring the successful outcome of the virtual course\u201d, she concludes.<\/p><p><strong>About CANBIO<\/strong><\/p><p>The CANBIO programme, which has a duration of 6.5 years, is a joint initiative of the Luxembourg Institute of Health, the University of Luxembourg and the Laboratoire National de Sant\u00e9, in collaboration with national and international partners, including the Centre Hospitalier de Luxembourg (CHL), the University of Bergen (Norway) and the University of Paris-Saclay (France). The programme is funded by the Luxembourg National Research Fund (FNR) through the competitive PRIDE programme and by intramural funds from the Luxembourg Ministry of Higher Education and Research (MESR).<\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>In the frame of the Cancer Biology \u201cCANBIO\u201d doctoral training unit launched in 2016 by the University of Luxembourg, the Luxembourg Institute of Health (LIH) and the Laboratoire National de Sant\u00e9 (LNS), the first virtual PhD defence and online training module took place at the time of COVID-19.<\/p>\n","protected":false},"author":0,"featured_media":310,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[],"news-topic":[],"organisation":[24],"authorship":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - 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