{"id":2688,"date":"2024-09-02T11:12:01","date_gmt":"2024-09-02T09:12:01","guid":{"rendered":"https:\/\/www.uni.lu\/fstm-fr\/?post_type=news&p=2688"},"modified":"2024-09-02T11:19:32","modified_gmt":"2024-09-02T09:19:32","slug":"quel-est-le-meilleur-moment-pour-soigner-le-cancer","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/fstm-fr\/news\/quel-est-le-meilleur-moment-pour-soigner-le-cancer\/","title":{"rendered":"Quel est le meilleur moment pour soigner le cancer?\u00a0"},"content":{"rendered":"\n
\n

Des scientifiques de l’Universit\u00e9 du Luxembourg et du Granada Lab – Charit\u00e9 Comprehensive Cancer Center ont d\u00e9montr\u00e9 que des horaires de traitement sp\u00e9cifiques peuvent am\u00e9liorer de mani\u00e8re significative la mort des cellules tumorales et r\u00e9duire les effets secondaires. <\/p>\n\n\n\n

Les rythmes circadiens, des cycles biologiques internes qui r\u00e9gulent des processus essentiels tels que l’\u00e9veil et le sommeil, sont cruciaux pour le maintien de la sant\u00e9 globale. Les perturbations de ces rythmes peuvent avoir des r\u00e9percussions significatives sur la sant\u00e9 et contribuer \u00e0 l’apparition de diverses maladies. Aligner des traitements m\u00e9dicaux sur l’horloge circadienne du patient permet am\u00e9liorer consid\u00e9rablement l’efficacit\u00e9 des th\u00e9rapies. Malgr\u00e9 les avantages connus, l’application clinique des traitements bas\u00e9s sur l’horloge circadienne a \u00e9t\u00e9 limit\u00e9e par l’absence de strat\u00e9gies efficaces pour d\u00e9terminer le moment optimal d’administration de m\u00e9dicaments sp\u00e9cifiques. <\/p>\n\n\n\n

Pour combler cette lacune critique, une \u00e9quipe internationale interdisciplinaire de chercheurs a mis au point une m\u00e9thode pionni\u00e8re \u00e0 haut d\u00e9bit pour analyser la fa\u00e7on dont les cellules canc\u00e9reuses r\u00e9agissent aux m\u00e9dicaments \u00e0 diff\u00e9rents moments de la journ\u00e9e. R\u00e9sultat : un cadre de r\u00e9f\u00e9rence polyvalent mis au point en utilisant des syst\u00e8mes de monitoring pour surveiller les rythmes circadiens et en mettant en \u0153uvre des protocoles de traitement en fonction de l’heure de la journ\u00e9e. <\/p>\n\n\n\n

\u00ab Nous avons effectu\u00e9 une analyse statistique approfondie des donn\u00e9es des syst\u00e8mes de monitoring, y compris en appliquant divers algorithmes bas\u00e9s sur l’apprentissage automatique, pour mettre en \u00e9vidence la sensibilit\u00e9 aux m\u00e9dicaments en fonction du moment de la journ\u00e9e de diverses lign\u00e9es cellulaires canc\u00e9reuses\u00bb, indique l’\u00e9quipe de recherche compos\u00e9e du doctorant Jeff Didier<\/a>, de l\u2019assistant-postdoctorant S\u00e9bastien De Landtsheer<\/a>, et de Prof. Thomas Sauter<\/a>, du D\u00e9partement Sciences de la Vie et M\u00e9decine. <\/p>\n\n\n\n

Les implications de cette recherche sont significatives. En identifiant les types de cellules et les combinaisons de m\u00e9dicaments les plus r\u00e9actifs, l’\u00e9tude ouvre la voie \u00e0 des th\u00e9rapies contre le cancer plus personnalis\u00e9es et pr\u00e9cises. Cette avanc\u00e9e souligne l’importance de la synchronisation dans les traitements contre le cancer et pourrait transformer les pratiques cliniques. <\/p>\n\n\n\n

Publication : \u00ab Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping<\/a> \u00bb, Nature Communications, ao\u00fbt 2024. <\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"

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