{"id":3607,"date":"2023-09-08T15:56:03","date_gmt":"2023-09-08T13:56:03","guid":{"rendered":"https:\/\/www.uni.lu\/fstm-en\/blog\/research-groups\/systems-biology\/research\/"},"modified":"2026-03-12T11:52:11","modified_gmt":"2026-03-12T10:52:11","slug":"research","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><!-- SecondaryNavigationMirror --><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"fe1d846c-a98d-4380-b964-2b19c87c886e\">\n    <nav id=\"secondary-navigation\" role=\"navigation\" aria-label=\"Secondary menu\" class=\"secondary-nav\">\n        <button class=\"secondary-nav__button btn btn-solid--primary w-full\" aria-expanded=\"false\" aria-controls=\"secondary-navigation__list\" title=\"The selected page is Research\" type=\"button\">\n            <span class=\"btn__name mr-auto\">Research<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Overview<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link isactived\" aria-current=\"page\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Research<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/people\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/join-us\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Join us<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<!-- end SecondaryNavigationMirror --><\/div><\/section>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"our-research\"\n    >\nOur research<\/h1>\n\n\n\n<p>Our work focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches. More specifically we are working on:<\/p>\n\n\n\n<p><strong>Epigenomics \/ Network Reconstruction<\/strong><\/p>\n\n\n\n<p>Most of the experimental and computational tools we are developing are applicable to a wide range of biological systems and processes.<\/p>\n\n\n\n<p>Ongoing more general work in the different applications comprises:<\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Genome-wide Epigenomics \/ Transcriptomics approaches like RNA-seq, ChIP-seq, (single nuclei) ATAC-seq, Multiome ATAC+RNA analysis, CUT&amp;Tag, Low-C, and nanopore sequencing, including downstream data analysis (Epigenetics team led by <a href=\"https:\/\/www.uni.lu\/en\/person\/NTAwMDMxMDJfX0xhc3NlIFNJTktLT05FTg==\">Dr. Lasse Sinkkonen<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Gene regulatory network reconstruction via integration of transcriptomic and epigenomic data (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30544251\/\" target=\"_blank\" rel=\"noreferrer noopener\">30544251<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38177910\/\" target=\"_blank\" rel=\"noreferrer noopener\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38177910\/\">38177910<\/a><\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Metabolic network reconstruction  (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24453953\" target=\"_blank\" rel=\"noreferrer noopener\">24453953<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36557249\/\" target=\"_blank\" rel=\"noreferrer noopener\">36557249<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31126892\/\" target=\"_blank\" rel=\"noreferrer noopener\">31126892<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26834640\" target=\"_blank\" rel=\"noreferrer noopener\">26834640<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26480823\" target=\"_blank\" rel=\"noreferrer noopener\">26480823<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26615025\" target=\"_blank\" rel=\"noreferrer noopener\">26615025<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41372842\/\">41372842<\/a>): <a href=\"https:\/\/github.com\/sysbiolux\/rFASTCORMICS\">FASTCORE algorithms<\/a><\/li>\n\n\n\n<li class=\"ulux-list-item\">Multiscale metabolic modelling &nbsp;(<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26904548\" target=\"_blank\" rel=\"noreferrer noopener\">26904548<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30787451\/\" target=\"_blank\" rel=\"noreferrer noopener\">30787451<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Signalling network reconstruction \/ Fast contextualisation of logical networks (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23815817\" target=\"_blank\" rel=\"noreferrer noopener\">28673016<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29872402\" target=\"_blank\" rel=\"noreferrer noopener\">29872402<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23815817\">23815817<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24983623\" target=\"_blank\" rel=\"noreferrer noopener\">24983623<\/a>, <a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/65912\">41006334<\/a>): <a href=\"https:\/\/github.com\/sysbiolux\/FALCON\" target=\"_blank\" rel=\"noreferrer noopener\">FALCON toolbox<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>Network Analysis \/ Machine Learning: <\/strong><\/p>\n\n\n\n<p>Once large-scale data are integrated in a network or machine learning model, these can be analysed for systemic features and experimental design:<\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Data Mining of human cohort data &amp; Disease Risk Stratification (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33244054\/\" target=\"_blank\" rel=\"noreferrer noopener\">33244054<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Metabolic network based Drug Repositioning &nbsp;(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31126892\/\" target=\"_blank\" rel=\"noreferrer noopener\">31126892<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32369553\/\" target=\"_blank\" rel=\"noreferrer noopener\">32369553<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Signalling network based Drug Target Identification (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30416750\/\" target=\"_blank\" rel=\"noreferrer noopener\">30416750<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30323272\/\" target=\"_blank\" rel=\"noreferrer noopener\">30323272<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Identification of Key Transcription Factors and Reprogramming Determinants&nbsp;(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38177910\/\">38177910<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30544251\/\" target=\"_blank\" rel=\"noreferrer noopener\">30544251<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34686322\/\">34686322<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34503558\/\">34503558<\/a>, <a href=\"https:\/\/algorecell.lri.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">AlgoReCell<\/a>, <a href=\"https:\/\/www.uni.lu\/research-en\/ias\/funded-projects\/audacity\/#2021\">GENERIC<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Integrated analysis of transcript-level regulation of metabolism (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26480823\" target=\"_blank\" rel=\"noreferrer noopener\">26480823<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24198249\" target=\"_blank\" rel=\"noreferrer noopener\">24198249<\/a>, IHEC)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Model ensembling as a tool to form interpretable multi-omic predictors of cancer pharmacosensitivity (<a href=\"https:\/\/orbilu.uni.lu\/bitstream\/10993\/62566\/1\/bbae567.pdf\">39494610<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Clinical data-driven classification of pre-frailty reveals sex-specific patterns &#8211; Data from the Berlin Aging Study II (BASE-II) (<a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/65916\" target=\"_blank\" rel=\"noreferrer noopener\">41005713<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping (<a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/61871\">39169017<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity (<a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/64831\">39994450<\/a>)<\/li>\n<\/ul>\n\n\n\n<p><strong><strong>Cancer specific Molecular Networks \/ Drug Discovery:<\/strong><\/strong><\/p>\n\n\n\n<p>By reconstructing and analysing cancer and subtype specific molecular networks, data integration is achieved, and specific drug discovery is enabled, ultimately aiming for personalized treatment. A specific interest lays in drug repositioning of established drugs for novel use in cancer treatment. We are contributing to fight:<\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Melanoma (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37495601\/\" target=\"_blank\" rel=\"noreferrer noopener\">37495601<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30416750\" target=\"_blank\" rel=\"noreferrer noopener\">30416750<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32410672\/\" target=\"_blank\" rel=\"noreferrer noopener\">32410672<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30323272\/\" target=\"_blank\" rel=\"noreferrer noopener\">30323272<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30240588\/\" target=\"_blank\" rel=\"noreferrer noopener\">30240588<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24675998\" target=\"_blank\" rel=\"noreferrer noopener\">24675998<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22815735\" target=\"_blank\" rel=\"noreferrer noopener\">22815735<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35022419\/\">35022419<\/a>, <a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/61390\">38870061<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Colorectal cancer (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31126892\/\" target=\"_blank\" rel=\"noreferrer noopener\">31126892<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31042485\/\" target=\"_blank\" rel=\"noreferrer noopener\">31042485<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Head and Neck cancer  (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31308358\/\" target=\"_blank\" rel=\"noreferrer noopener\">31308358<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30142511\/\" target=\"_blank\" rel=\"noreferrer noopener\">30142511<\/a>, <a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/63818\">39858048<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Breast cancer (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26631483\" target=\"_blank\" rel=\"noreferrer noopener\">26631483<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Glioblastoma (<a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/61139\">38701414<\/a>)<\/li>\n<\/ul>\n\n\n\n<p><strong><strong>Epigenetic Regulation in Cellular Differentiation and Disease<\/strong><\/strong><\/p>\n\n\n\n<p>The research focus of the Epigenetics team is understanding gene regulation and epigenetic mechanisms that determine cell identity in differentiation and disease in mammalian cells. We use <em>in vitro<\/em> cell culture systems, human cell types derived from induced pluripotent stem cells and primary cells from human and mouse tissues to apply genome-wide epigenomics approaches like RNA-seq, ChIP-seq, CUT&amp;Tag, Lo-C, single nuclei ATAC+RNA-seq, and nanopore sequencing to study how cells differentiate and maintain their identity. We focus on gene control at the chromatin level and how this is perturbed in disease states like Parkinson\u2019s disease and cancer, for example through regulatory genetic variation, changes in gene regulatory networks, or altered activity of chromatin modifiers. Through collaborative projects also other model organisms such as budding yeast are being studied.<\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Epigenetic control of cell identity and differentiation (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38177910\/\">38177910<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34686322\/\">34686322<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34503558\/\">34503558<\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30544251\/\" target=\"_blank\" rel=\"noreferrer noopener\">30544251<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24457907\" target=\"_blank\" rel=\"noreferrer noopener\">24457907<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31044623\/\" target=\"_blank\" rel=\"noreferrer noopener\">31044623<\/a>,&nbsp;<a href=\"https:\/\/www.uni.lu\/research-en\/ias\/funded-projects\/audacity\/#2021\">GENERIC<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Non-coding regulatory variation in complex traits and diseases (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34503558\/\">34503558<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34453370\/\">34453370<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32248367\/\">32248367<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33173537\/\" target=\"_blank\" rel=\"noreferrer noopener\">33173537<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31621607\/\" target=\"_blank\" rel=\"noreferrer noopener\">31621607<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26338775\/\">26338775<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Interplay of metabolism and epigenetic regulation (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38011998\/\">38011998<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36848289\/\">36848289<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35892629\/\">35892629<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24198249\/\">24198249<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41372842\/\">41372842<\/a>)<\/li>\n\n\n\n<li class=\"ulux-list-item\">Epigenetic underpinning of sex-specific changes in neurodegenerative diseases (<a href=\"https:\/\/orbilu.uni.lu\/handle\/10993\/63473\">39755720<\/a>)<\/li>\n<\/ul>\n<\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"research-projects\"\n    >\nResearch projects<\/h2>\n\n\n<ul class=\"flex flex-wrap mt-24 -mx-16  wp-block-unilux-blocks-free-content-card\">\n    <li class=\"w-full sm:w-1\/2 lg:w-1\/3 px-16  wp-block-unilux-blocks-free-content-card-item\">\n    <div class=\"ulux-card card-project-related bg-theme\">\n        <div class=\"ulux-card__container card__container\">\n                        <div class=\"ulux-card__body wp-block-unilux-blocks-free-content-card-item-body\">\n    \n<span class=\"ulux-card__related wp-block-unilux-blocks-plain-text\">GENERIC<\/span>\n<h3 class=\"ulux-card__title has-text-align-left wp-block-unilux-blocks-heading\"        id=\"reconstructing-gene-regulatory-networks-with-neural-relational-inference\"\n    >\nReconstructing gene regulatory networks with neural relational inference<\/h3>\n<div class=\"ulux-card__link-wrapper card__link wp-block-unilux-blocks-simple-cta\">\n    <a\n        href=\"https:\/\/www.uni.lu\/fstm-en\/research-projects\/generic\/\"\n        title=\"Learn more\"\n        class=\"link-text link-text--icon ulux-card__link link-text link-absolute\"\n        target=\"\"\n    >\n        <span class=\"link-text__body\">\n            <span class=\"link-text__name\">Learn more<\/span>\n        <\/span>\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/a>\n<\/div>\n<\/div>        <\/div>\n    <\/div>\n<\/li><li class=\"w-full sm:w-1\/2 lg:w-1\/3 px-16  wp-block-unilux-blocks-free-content-card-item\">\n    <div class=\"ulux-card card-project-related bg-theme\">\n        <div class=\"ulux-card__container card__container\">\n                        <div class=\"ulux-card__body wp-block-unilux-blocks-free-content-card-item-body\">\n    \n<span class=\"ulux-card__related wp-block-unilux-blocks-plain-text\">DRIVEN<\/span>\n<h3 class=\"ulux-card__title has-text-align-left wp-block-unilux-blocks-heading\"        id=\"data-driven-computational-modelling-and-applications\"\n    >\nData-driven computational modelling and applications<\/h3>\n<div class=\"ulux-card__link-wrapper card__link wp-block-unilux-blocks-simple-cta\">\n    <a\n        href=\"https:\/\/www.uni.lu\/fstm-en\/research-projects\/driven\"\n        title=\"Learn more\"\n        class=\"link-text link-text--icon ulux-card__link link-text link-absolute\"\n        target=\"\"\n    >\n        <span class=\"link-text__body\">\n            <span class=\"link-text__name\">Learn more<\/span>\n        <\/span>\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/a>\n<\/div>\n<\/div>        <\/div>\n    <\/div>\n<\/li><li class=\"w-full sm:w-1\/2 lg:w-1\/3 px-16  wp-block-unilux-blocks-free-content-card-item\">\n    <div class=\"ulux-card card-project-related bg-theme\">\n        <div class=\"ulux-card__container card__container\">\n                        <div class=\"ulux-card__body wp-block-unilux-blocks-free-content-card-item-body\">\n    \n<span class=\"ulux-card__related wp-block-unilux-blocks-plain-text\">CANBIO II<\/span>\n<h3 class=\"ulux-card__title has-text-align-left wp-block-unilux-blocks-heading\"        id=\"training-in-cancer-biology-2-focus-on-the-tumor-ecosystem\"\n    >\nTraining in Cancer Biology 2: Focus on the Tumor Ecosystem<\/h3>\n<div class=\"ulux-card__link-wrapper card__link wp-block-unilux-blocks-simple-cta\">\n    <a\n        href=\"https:\/\/www.uni.lu\/research-en\/research-projects\/canbio2\/\"\n        title=\"Learn more\"\n        class=\"link-text link-text--icon ulux-card__link link-text link-absolute\"\n        target=\"\"\n    >\n        <span class=\"link-text__body\">\n            <span class=\"link-text__name\">Learn more<\/span>\n        <\/span>\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/a>\n<\/div>\n<\/div>        <\/div>\n    <\/div>\n<\/li><li class=\"w-full sm:w-1\/2 lg:w-1\/3 px-16  wp-block-unilux-blocks-free-content-card-item\">\n    <div class=\"ulux-card card-project-related bg-theme\">\n        <div class=\"ulux-card__container card__container\">\n                        <div class=\"ulux-card__body wp-block-unilux-blocks-free-content-card-item-body\">\n    \n<span class=\"ulux-card__related wp-block-unilux-blocks-plain-text\">NO-CANCER-NET<\/span>\n<h3 class=\"ulux-card__title has-text-align-left wp-block-unilux-blocks-heading\"        id=\"advanced-engineering-of-nitric-oxide-based-therapeutics-for-triple-negative-breast-cancer-training-network\"\n    >\nAdvanced Engineering of Nitric Oxide Based Therapeutics for Triple Negative Breast Cancer Training Network<\/h3>\n<div class=\"ulux-card__link-wrapper card__link wp-block-unilux-blocks-simple-cta\">\n    <a\n        href=\"https:\/\/www.uni.lu\/fstm-en\/research-projects\/no-cancer-net\"\n        title=\"Learn more\"\n        class=\"link-text link-text--icon ulux-card__link link-text link-absolute\"\n        target=\"\"\n    >\n        <span class=\"link-text__body\">\n            <span class=\"link-text__name\">Learn more<\/span>\n        <\/span>\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/a>\n<\/div>\n<\/div>        <\/div>\n    <\/div>\n<\/li><\/ul>\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list justify-center\"><li class=\"wp-block-unilux-blocks-custom-button\"    aria-disabled=\"false\"\n    >\n    <a\n        role=\"link\"\n        aria-disabled=\"false\"\n                    href=\"https:\/\/www.uni.lu\/research-en\/research-projects-overview\/?fq_research-projects-taxonomies-organisation%5B%5D=systems-biology%7CSystems+Biology%7COrganisation\"\n                target=\"_self\"\n        class=\"btn btn--primary\"\n            >All projects<\/a>\n<\/li>\n<\/ul>\n<\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"publications\"\n    >\nPublications<\/h1>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\"><a href=\"https:\/\/orbilu.uni.lu\/profile?uid=50002988\">Systems Biology<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\"><a href=\"https:\/\/orbilu.uni.lu\/profile?uid=50003102\">Epigenetics<\/a><\/li>\n<\/ul>\n\n\n\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"software\"\n    >\nSoftware<\/h1>\n\n\n\n<p><strong>GitHub repository<\/strong>: <a href=\"https:\/\/github.com\/sysbiolux\" target=\"_blank\" rel=\"noreferrer noopener\">sysbiolux<\/a><\/p>\n<\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Our research focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches.<\/p>\n","protected":false},"author":110,"featured_media":24040,"parent":3606,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"Systems Biology and Epigenetics","uluxPrePostTitle":"Research Group","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"field-of-interest":[],"organisation":[],"authorship":[110,108,102,136,314],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Systems Biology and Epigenetics - Systems Biology and Epigenetics - FSTM research group I University of Luxembourg<\/title>\n<meta name=\"description\" content=\"Our research focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research\" \/>\n<meta property=\"og:description\" content=\"Our research focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"FSTM EN\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/fstm.uni.lu\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-12T10:52:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/\",\"url\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/\",\"name\":\"Research Systems Biology and Epigenetics - Systems Biology and Epigenetics - FSTM research group I University of Luxembourg\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg\",\"datePublished\":\"2023-09-08T13:56:03+00:00\",\"dateModified\":\"2026-03-12T10:52:11+00:00\",\"description\":\"Our research focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#primaryimage\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg\",\"width\":1920,\"height\":2560},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.uni.lu\/en\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Faculty of Science, Technology and Medicine\",\"item\":\"https:\/\/www.uni.lu\/fstm-en\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research Groups\",\"item\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Systems Biology and Epigenetics\",\"item\":\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/#website\",\"url\":\"https:\/\/www.uni.lu\/fstm-en\/\",\"name\":\"FSTM\",\"description\":\"Faculty of Science, Technology and Medicine I Uni.lu\",\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/#organization\"},\"alternateName\":\"Faculty of Science, Technology and Medicine I University of Luxembourg\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.uni.lu\/fstm-en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/#organization\",\"name\":\"FSTM - University of Luxembourg I Uni.lu\",\"alternateName\":\"Faculty of Science, Technology and Medicine\",\"url\":\"https:\/\/www.uni.lu\/fstm-en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2026\/03\/03111650\/FSTM_SM-Profile_1600x1600px-scaled.jpg\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2026\/03\/03111650\/FSTM_SM-Profile_1600x1600px-scaled.jpg\",\"width\":2560,\"height\":2560,\"caption\":\"FSTM - University of Luxembourg I Uni.lu\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/fstm.uni.lu\/\",\"https:\/\/www.linkedin.com\/showcase\/fstm-uni-lu\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Research Systems Biology and Epigenetics - Systems Biology and Epigenetics - FSTM research group I University of Luxembourg","description":"Our research focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/","og_locale":"en_GB","og_type":"article","og_title":"Research","og_description":"Our research focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches.","og_url":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/","og_site_name":"FSTM EN","article_publisher":"https:\/\/www.facebook.com\/fstm.uni.lu\/","article_modified_time":"2026-03-12T10:52:11+00:00","og_image":[{"width":1920,"height":2560,"url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimated reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/","url":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/","name":"Research Systems Biology and Epigenetics - Systems Biology and Epigenetics - FSTM research group I University of Luxembourg","isPartOf":{"@id":"https:\/\/www.uni.lu\/fstm-en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#primaryimage"},"image":{"@id":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#primaryimage"},"thumbnailUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg","datePublished":"2023-09-08T13:56:03+00:00","dateModified":"2026-03-12T10:52:11+00:00","description":"Our research focuses on molecular systems biology, applying methodologies like epigenomics and transcriptomics together with cutting-edge data analysis and integration techniques, including statistical methods, machine learning, and network-based approaches. Our interdisciplinary research projects usually combine both experimental laboratory work and computational biology approaches.","breadcrumb":{"@id":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#primaryimage","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/UNI-1506-42-scaled.jpg","width":1920,"height":2560},{"@type":"BreadcrumbList","@id":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.uni.lu\/en"},{"@type":"ListItem","position":2,"name":"Faculty of Science, Technology and Medicine","item":"https:\/\/www.uni.lu\/fstm-en\/"},{"@type":"ListItem","position":3,"name":"Research Groups","item":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/"},{"@type":"ListItem","position":4,"name":"Systems Biology and Epigenetics","item":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/systems-biology-and-epigenetics\/"},{"@type":"ListItem","position":5,"name":"Research"}]},{"@type":"WebSite","@id":"https:\/\/www.uni.lu\/fstm-en\/#website","url":"https:\/\/www.uni.lu\/fstm-en\/","name":"FSTM","description":"Faculty of Science, Technology and Medicine I Uni.lu","publisher":{"@id":"https:\/\/www.uni.lu\/fstm-en\/#organization"},"alternateName":"Faculty of Science, Technology and Medicine I University of Luxembourg","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.uni.lu\/fstm-en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/www.uni.lu\/fstm-en\/#organization","name":"FSTM - University of Luxembourg I Uni.lu","alternateName":"Faculty of Science, Technology and Medicine","url":"https:\/\/www.uni.lu\/fstm-en\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.uni.lu\/fstm-en\/#\/schema\/logo\/image\/","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2026\/03\/03111650\/FSTM_SM-Profile_1600x1600px-scaled.jpg","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2026\/03\/03111650\/FSTM_SM-Profile_1600x1600px-scaled.jpg","width":2560,"height":2560,"caption":"FSTM - University of Luxembourg I Uni.lu"},"image":{"@id":"https:\/\/www.uni.lu\/fstm-en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/fstm.uni.lu\/","https:\/\/www.linkedin.com\/showcase\/fstm-uni-lu"]}]}},"_links":{"self":[{"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/research-groups\/3607"}],"collection":[{"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/research-groups"}],"about":[{"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/types\/research-groups"}],"author":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/users\/110"}],"version-history":[{"count":4,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/research-groups\/3607\/revisions"}],"predecessor-version":[{"id":46202,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/research-groups\/3607\/revisions\/46202"}],"up":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/research-groups\/3606"}],"wp:authorship":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/users\/110"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/users\/108"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/users\/102"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/users\/136"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/users\/314"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/media\/24040"}],"wp:attachment":[{"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/media?parent=3607"}],"wp:term":[{"taxonomy":"field-of-interest","embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/field-of-interest?post=3607"},{"taxonomy":"organisation","embeddable":true,"href":"https:\/\/www.uni.lu\/fstm-en\/wp-json\/wp\/v2\/organisation?post=3607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}