{"id":3603,"date":"2023-09-08T15:55:57","date_gmt":"2023-09-08T13:55:57","guid":{"rendered":"https:\/\/www.uni.lu\/fstm-en\/blog\/research-groups\/signal-transduction-group\/research\/"},"modified":"2026-03-30T16:48:48","modified_gmt":"2026-03-30T14:48:48","slug":"research","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/fstm-en\/research-groups\/signal-transduction\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><!-- SecondaryNavigationMirror --><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"fdbe6ca5-b1af-4d99-bcfd-db693e8e8096\">\n    <nav id=\"secondary-navigation\" role=\"navigation\" aria-label=\"Secondary menu\" class=\"secondary-nav\">\n        <button class=\"secondary-nav__button btn btn-solid--primary w-full\" aria-expanded=\"false\" aria-controls=\"secondary-navigation__list\" title=\"The selected page is Overview\" type=\"button\">\n            <span class=\"btn__name mr-auto\">Overview<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/signal-transduction\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Overview<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/signal-transduction\/research\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link isactived\" aria-current=\"page\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Research<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/signal-transduction\/people\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/signal-transduction\/join-us\/\" target=\"\" rel=\"noreferrer noopener\" class=\"secondary-nav__link \">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Join us<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<!-- end SecondaryNavigationMirror --><\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"research-at-the-signal-transduction-group\"\n    >\nResearch at the Signal Transduction group<\/h1>\n\n\n\n<p>Numerous diseases are caused by a dysfunctional cellular signal transduction. Thus, the Signal Transduction group works on the understanding of cellular signalling pathways and its underlying molecular mechanisms, a crucial step for the development of novel drugs targeting cellular communication pathways.<\/p>\n<\/div><\/section>\n\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><div class=\"content-card content-card--right content-card__overlay--hidden wp-block-unilux-blocks-content-card\">\n    \n<h2 class=\"content-card__heading has-text-align-left wp-block-unilux-blocks-heading\"    >\nBetter understanding of cellular signal transduction<\/h2>\n<div class=\"content-card__visual wp-block-unilux-blocks-content-card-visual-area\">\n    \n<section class=\"wp-block-unilux-blocks-image-video-wrapper\">\n    <figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/Image2.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/Image2-300x292.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/Image2-768x748.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/09\/Image2.png 866w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 3\/2; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/section>\n<div class=\"wp-block-unilux-blocks-wrapper content-card__overlay\">\n<a class=\"wp-block-unilux-blocks-button-highlight-rounded bottom-left\" \n    href=\"#\"\n    target=\"_self\"\n>\n    \n<span class=\"btn-highlight-rounded__name wp-block-unilux-blocks-plain-text\"><\/span>    <span class=\"icon-rounded\">\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right icon--lg\"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/span>\n<\/a><\/div>\n<\/div><div class=\"content-card__body  wp-block-unilux-blocks-content-card-free-area\">\n    \n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Signal transduction at the cellular level refers to the transduction of signals from the outside of the cell to the inside. This involves the coupling of ligand-receptor interactions to intracellular events. Post-translational modifications change protein conformations and enzyme activities. The eventual outcome is an alteration in cellular activity and changes in the program of genes expressed within the responding cells.Numerous diseases are caused by a dysfunctional cellular signal transduction. The uncontrolled growth of tumor cells is caused by mutations in the genes encoding growth factors, their receptors, signal transducing enzymes (mostly kinases), and transcription factors. Moreover, deregulation of microRNAs contributes to cancer development.Recent exciting examples of successful transpositions of basic signal transduction research into clinical applications include kinase inhibitors used in tumor therapy or microRNA inhibitors used in treatment of hepatitis C patients. Thus, a thorough understanding of cellular signal transduction and its underlying molecular mechanisms is crucial for the development of novel drugs targeting cellular communication pathways.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>The research activities of the Signal Transduction group focuses on two main research Domains:<br><br>Jak\/STAT Research topics:<\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Molecular mechanisms of cytokine signal transduction mediated by Janus kinases and STAT transcription factors<\/li>\n\n\n\n<li class=\"ulux-list-item\">(Patho)physiologic consequences of Jak\/STAT signaling and cross-talk with other signalling pathways (e.g. hypoxia)<\/li>\n<\/ul>\n\n\n\n<p>Melanoma Research topics: <\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Melanoma 3D models<\/li>\n\n\n\n<li class=\"ulux-list-item\">mechanisms of resistance mechanisms<\/li>\n\n\n\n<li class=\"ulux-list-item\">Drug screening in novel 3D cell models<\/li>\n\n\n\n<li class=\"ulux-list-item\">miRNAs and other non-coding RNAs:   regulation, function, role as biomarkers, transmission by exosomes<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"research-projects\"\n    >\nResearch projects<\/h2>\n\n\n<ul class=\"flex flex-wrap mt-24 -mx-16  wp-block-unilux-blocks-free-content-card\">\n    <li class=\"w-full sm:w-1\/2 lg:w-1\/3 px-16  wp-block-unilux-blocks-free-content-card-item\">\n    <div class=\"ulux-card card-project-related bg-theme\">\n        <div class=\"ulux-card__container card__container\">\n                        <div class=\"ulux-card__body wp-block-unilux-blocks-free-content-card-item-body\">\n    \n<span class=\"ulux-card__related wp-block-unilux-blocks-plain-text\">CANBIO II<\/span>\n<h3 class=\"ulux-card__title has-text-align-left wp-block-unilux-blocks-heading\"        id=\"training-in-cancer-biology-2-focus-on-the-tumor-ecosystem\"\n    >\nTraining in Cancer Biology 2: Focus on the Tumor Ecosystem<\/h3>\n<div class=\"ulux-card__link-wrapper card__link wp-block-unilux-blocks-simple-cta\">\n    <a\n        href=\"https:\/\/www.uni.lu\/research-en\/research-projects\/canbio2\/\"\n        title=\"Learn more\"\n        class=\"link-text link-text--icon ulux-card__link link-text link-absolute\"\n        target=\"\"\n    >\n        <span class=\"link-text__body\">\n            <span class=\"link-text__name\">Learn more<\/span>\n        <\/span>\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/a>\n<\/div>\n<\/div>        <\/div>\n    <\/div>\n<\/li><li class=\"w-full sm:w-1\/2 lg:w-1\/3 px-16  wp-block-unilux-blocks-free-content-card-item\">\n    <div class=\"ulux-card card-project-related bg-theme\">\n        <div class=\"ulux-card__container card__container\">\n                        <div class=\"ulux-card__body wp-block-unilux-blocks-free-content-card-item-body\">\n    \n<span class=\"ulux-card__related wp-block-unilux-blocks-plain-text\">MelCol-PFP<\/span>\n<h3 class=\"ulux-card__title has-text-align-left wp-block-unilux-blocks-heading\"        id=\"personal-functional-profiling-for-drug-discovery-in-melanoma-and-colorectal-cancer\"\n    >\nPersonal functional profiling for drug discovery in melanoma and colorectal cancer<\/h3>\n<div class=\"ulux-card__link-wrapper card__link wp-block-unilux-blocks-simple-cta\">\n    <a\n        href=\"https:\/\/www.uni.lu\/fstm-en\/research-projects\/melcol-pfp\/\"\n        title=\"Learn more\"\n        class=\"link-text link-text--icon ulux-card__link link-text link-absolute\"\n        target=\"\"\n    >\n        <span class=\"link-text__body\">\n            <span class=\"link-text__name\">Learn more<\/span>\n        <\/span>\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg>    <\/a>\n<\/div>\n<\/div>        <\/div>\n    <\/div>\n<\/li><\/ul>\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list justify-center\"><li class=\"wp-block-unilux-blocks-custom-button\"    aria-disabled=\"false\"\n    >\n    <a\n        role=\"link\"\n        aria-disabled=\"false\"\n                    href=\"https:\/\/www.uni.lu\/research-en\/research-projects-overview\/?fq_research-projects-taxonomies-organisation%5B%5D=signal-transduction-group%7CSignal+Transduction+Group%7COrganisation\"\n                target=\"_self\"\n        class=\"btn btn--primary\"\n            >All projects<\/a>\n<\/li>\n<\/ul>\n<\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Numerous diseases are caused by a dysfunctional cellular signal transduction. Thus, the Signal Transduction group works on the understanding of cellular signalling pathways and its underlying molecular mechanisms, a crucial step for the development of novel drugs targeting cellular communication pathways.<\/p>\n","protected":false},"author":314,"featured_media":24058,"parent":3602,"menu_order":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"Signal Transduction","uluxPrePostTitle":"Research Group","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"field-of-interest":[],"organisation":[],"authorship":[110,108,102,136,314],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Signal Transduction - Signal Transduction - FSTM research group I University of Luxembourg<\/title>\n<meta name=\"description\" content=\"Numerous diseases are caused by a dysfunctional cellular signal transduction. 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