{"id":328,"date":"2023-06-26T07:34:47","date_gmt":"2023-06-26T07:34:47","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/fstm-en\/?page_id=328"},"modified":"2024-02-20T09:22:19","modified_gmt":"2024-02-20T08:22:19","slug":"colorectal-cancer-sample-collection","status":"publish","type":"page","link":"https:\/\/www.uni.lu\/fstm-en\/colorectal-cancer-sample-collection\/","title":{"rendered":"Colorectal cancer sample collection"},"content":{"rendered":"<div class=\"section py-0 static\">\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"0259cb3b-2ab8-4e82-b5d3-7ad0557195a9\">\n    <nav\n        id=\"secondary-navigation\"\n        role=\"navigation\"\n        aria-label=\"Secondary menu\"\n        class=\"secondary-nav\"\n    >\n        <button\n            class=\"secondary-nav__button btn btn-solid--primary w-full\"\n     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xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Contact<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"take-part-in-colorectal-cancer-crc-research\"\n    >\n<strong>Take part in colorectal cancer (CRC) research<\/strong><\/h1>\n\n\n\n<p>Did you know that CRC patients can help cancer research by authorizing sample collection?<\/p>\n\n\n\n<p>The main reason to participate is to help researchers better understand the disease and find better treatments . Participants should not expect an immediate benefit from the study; however, your participation is extremely important because you will provide key information to advance research on colorectal cancer which in the long run will benefit CRC patients.&nbsp;<\/p>\n\n\n\n<p>Participation is, of course, voluntary and it mostly consists in collecting a sample of the tumor tissues excised as a part of the standard clinical procedure.<\/p>\n\n\n\n<p>If you are interested to help, please ask your doctor about the sample collection project.<\/p>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"about-the-colorectal-cancer-collection\"\n    >\n<br><strong>About the colorectal cancer collecti<\/strong>on<\/h2>\n\n\n\n<p>The colorectal cancer collection, initiated in 2010, is a joint effort, involving oncologists and surgeons from the <strong>Centre Hospitalier Emile Mayrisch (CHEM)<\/strong>,<strong> <\/strong>the<strong> Center Hospitalier Luxembourgeois (CHL)<\/strong>, the <strong>Robert Schuman hospitals (HRS)<\/strong>, and the<strong> Center Hospitalier du Nord (CHdN)<\/strong>, nurses from the<strong>Clinical and Epidemiological Investigation Center at LIH, <\/strong>pathologists fromthe<strong> LNS <\/strong>as well as collection managers atthe<strong> IBBL <\/strong>and researchers atthe<strong> University of Luxembourg<\/strong>. Of note, the collection contains tumor tissues as well as normal counterparts from the same patients and different other collection samples such as blood and stool samples. For all patient samples, the clinical information, as well as the molecular data belonging to them, is accessible. This allows studying clinical parameters, ultimately leading to <strong>potential interesting translational findings<\/strong>. Importantly, all these samples can be shared within the research community in Luxembourg and abroad and feed additional colorectal cancer studies and fruitful collaborations.<br>The collection has currently 180 patients enrolled and almost 4000 samples collected. As we collect the tumor cells as well as the different cells of the tumor microenvironment, we can generate \u201cmini tumors\u201d in the lab (also called organoids) which nicely <strong>recapitulate the original tumor<\/strong> and which foster <strong>personalized medicine<\/strong>.<\/p>\n\n\n\n<p>Funding: Fondation cancer, FNR and UniLu<\/p>\n\n\n<div class=\"thumbnail  wp-block-unilux-blocks-thumbnail-video\">\n    <div class=\"card bg-theme p-0\">\n        <div class=\"card__container p-0\">\n            <div class=\"card__body p-0\">\n                <iframe \n            src=\"\" \n            title=\"YouTube video player\" frameborder=\"0\" \n            allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" \n            style=\"object-position: 50% 50%; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n            allowfullscreen data-cookieconsent=\"ignore\">\n            <\/iframe>                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div class=\"thumbnail  wp-block-unilux-blocks-thumbnail-video\">\n    <div class=\"card bg-theme p-0\">\n        <div class=\"card__container p-0\">\n            <div class=\"card__body p-0\">\n                <iframe \n            src=\"\" \n            title=\"YouTube video player\" frameborder=\"0\" \n            allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" \n            style=\"object-position: 50% 50%; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n            allowfullscreen data-cookieconsent=\"ignore\">\n            <\/iframe>                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"about-colorectal-cancer\"\n    >\n<br><strong>About colorectal cancer<\/strong><\/h2>\n\n\n\n<p><strong>Colorectal cancer (CRC)<\/strong> is one of the most common and lethal malignancies in Western countries. It is the most commonly diagnosed cancer in Europe and <strong>the second most common cause of cancer death<\/strong>. In Luxembourg, colorectal cancer is the second most common cancer (National Cancer Registry). Importantly, <strong>an increase in CRC incidence in young adults<\/strong> (individuals below 50 years of age) has been observed in different parts of the world, such as the USA and Australia.<\/p>\n\n\n\n<p>The <strong>high incidence and mortality rates <\/strong>emphasize the need for prevention and early diagnosis. Efficient treatments are still missing for advanced CRC patients with chemotherapy being the standard strategy. There is therefore an urgent need to identify <strong>novel therapeutic intervention points<\/strong> for CRC patients.<\/p>\n\n\n\n<p>Awareness of the target population of colorectal cancer and screening is crucial in order to increase screening participation rates. In Luxembourg, a <strong>national colorectal cancer screening program<\/strong> is open for men and women between 55 and 74 years old who are invited by mail to participate every two years.<\/p>\n\n\n\n<p>The <strong><a href=\"https:\/\/www.uni.lu\/fstm-en\/research-groups\/molecular-disease-mechanisms\/\">Molecular Disease Mechanisms Group (MDM)<\/a> <\/strong>of the Department of Life Sciences and Medicine (UL), led by Prof. E. Letellier and Prof. S. Haan, has a profound interest in dissecting the <strong>molecular mechanisms involved in the development of CRC <\/strong>as well as in the <strong>different drug resistance mechanisms<\/strong> by focusing on the metabolic changes in tumor cells and in the cells of the microenvironment (stromal cells and microbio<\/p>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"our-ongoing-research-projects\"\n    >\n<br><strong>Our ongoing research projects<\/strong><\/h2>\n\n\n\n<p><strong><u>Biomarkers for CRC<\/u><\/strong>: We have identified promising biomarkers with a strong prognostic value in early CRC stages. One of our recently identified biomarkers has led to the filing of a patent on novel biomarkers for cancer diagnosis, prediction, or staging. We are currently aiming at translating this biomarker into the clinical setting.<\/p>\n\n\n\n<p>Supported by: FNR Proof of Concept Study (MyoRPROG) and Foundation Vera Nijs&amp;Jens Eric Rosborg<\/p>\n\n\n\n<p>PI: Elisabeth Letellier<\/p>\n\n\n\n<p><strong><u>Microbiome and CRC<\/u><\/strong>: It has been shown that dysbiosis, a state of pathological imbalance in the microbiome, is present in patients suffering from colorectal cancer. Accordingly, several microbiome studies identified specific bacteria being associated with CRC. Nevertheless, the role of bacteria in the etiology of the disease remains unknown. In this project, we aim at studying CRC-associated bacteria, their role in colon cancer tumor initiation and progression and the influence of diet on these processes.<\/p>\n\n\n\n<p>Supported by: FNR PRIDE MICROH Doctoral Training Unit project, FNR CORE MICROH-CRC and FNR BRIDGES<\/p>\n\n\n\n<p>PI: Elisabeth Letellier<\/p>\n\n\n\n<p><strong><u>Contribution of the tumor microenviroment to disease progression and therapy resisatnce<\/u><\/strong>: The tumor microenvironment has been shown to play an important role in tumor development, especially in cancer initiation and metastasis. Amongst all the various microenvironmental players, cancer associated fibroblasts (CAFs) have been suggested to play a key role in tumor development. Within this project, we study the role of CAFs in CRC and in therapy resistance.<\/p>\n\n\n\n<p>Supported by: FNR PRIDE Doctoral Training Unit project (CANBIO and CORE)<\/p>\n\n\n\n<p>PI: Elisabeth Letellier and Serge Haan<\/p>\n\n\n\n<p><strong><u>Personalized drug treatments for CRC patients<\/u><\/strong>: In close collaboration with the <strong>Disease Modeling and Screening Platform<\/strong> (DMSP, collaboration between UL and LIH), we are in the process of establishing robotic pipelines in order to be able to do high-throughput drug screening. The ultimate goal of this study is to test <strong>different drugs on the patient&#8217;s primary tumors<\/strong> and to report this result to the clinician so that he can orient himself towards new therapies in the event of therapeutic failure of the basic treatments.<\/p>\n\n\n\n<p>Supported by: FNR (MelColPFP), Fondation Marie Jeanne &amp; Edmond Schumacher and FNR i2TRON DTU<\/p>\n\n\n\n<p>PI: Elisabeth Letellier<\/p>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"press\"\n    >\n<br>Press<\/h2>\n\n\n\n<p><a href=\"https:\/\/www.uni.lu\/en\/news\/10-years-building-colorectal-cancer-collection\/\">10 years building colorectal cancer collection &#8211; University of Luxembourg I Uni.lu<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/sante.public.lu\/fr\/espace-professionnel\/plans-nationaux\/plan-national-cancer.html\">Cancer &#8211; Plan National 2020-2024 (prolong\u00e9 jusqu\u2019en 2026) &#8211; Portail Sant\u00e9 &#8211; Luxembourg (public.lu)<\/a><\/p>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"partners\"\n    >\n<br>Partners <\/h2>\n\n\n<figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2024\/01\/Image3.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2024\/01\/Image3-300x176.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2024\/01\/Image3-1024x599.png 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2024\/01\/Image3-768x449.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2024\/01\/Image3.png 1039w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>*** Donate to further support colon cancer research at the University of Luxembourg***<\/strong><\/p>\n\n\n\n<p>University of Luxembourg<\/p>\n\n\n\n<p>IBAN: LU22 0019 2955 8077 5000<\/p>\n\n\n\n<p>BIC: BCEELUL<\/p>\n\n\n\n<p>Major: Colon cancer research<\/p>\n<\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":33,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"Faculty of Science, Technology and Medicine (FSTM)","uluxPrePostTitle":"Faculty","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"field-of-interest":[],"organisation":[100,29,102],"authorship":[33],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Colorectal cancer sample collection - FSTM - University of Luxembourg I Uni.lu<\/title>\n<meta name=\"description\" content=\"Navigation Menu Did you know that CRC patients can help cancer research by authorizing sample collection? 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