{"id":1358,"date":"2023-07-24T12:57:01","date_gmt":"2023-07-24T12:57:01","guid":{"rendered":"https:\/\/www.uni.lu\/fstm-en\/?post_type=news&#038;p=1358"},"modified":"2023-08-02T06:10:00","modified_gmt":"2023-08-02T06:10:00","slug":"p2rx7-is-an-indicator-of-early-drug-response-in-nras-mutated-melanoma","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/fstm-en\/news\/p2rx7-is-an-indicator-of-early-drug-response-in-nras-mutated-melanoma\/","title":{"rendered":"P2RX7 is an indicator of early drug response in NRAS-mutated melanoma"},"content":{"rendered":"\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<p>Ground-breaking research in cancer biology and immunology in the last decades has revolutionized the treatment of melanoma, a deadly form of skin cancer. Nevertheless, cells inevitably become resistant to existing treatments and this poses a serious clinical problem. &nbsp;Understanding the molecular mechanisms of therapy resistance is crucial to develop more effective and specific treatments for melanoma patients, especially for patients of the \u201cNRAS genetic subtype\u201d.<\/p>\n\n\n\n<p>The <strong>Signal Transduction group<\/strong> at the Department of Life Sciences and Medicine (DLSM) at the University of Luxembourg dissected the drug resistance mechanisms in NRAS mutant melanomas and recently published their findings in <strong>Cell Reports<\/strong>. In this study, researchers from the DLSM in collaboration with colleagues from the Luxembourg Centre for Systems Biomedicine (Prof. Alex Skupin and Dr. Stefano Magni) could show that the ATP-gated ion channel P2RX7 is transiently increased in melanoma cells, that are under treatment.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/Melanoma.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/Melanoma-300x190.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/Melanoma-768x487.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/Melanoma.jpg 781w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/S-Kreis.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/S-Kreis-300x200.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/S-Kreis-1024x682.jpg 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/S-Kreis-768x512.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/S-Kreis-1536x1024.jpg 1536w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/S-Kreis.jpg 2000w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Expression returns to baseline once cells have adapted and subsequently tolerate drug treatment, as evidenced by their re-entering the cell cycle and resuming cell growth. \u201cOur results indicate that high levels of active P2RX7 could be a useful marker for a general response to treatment in NRAS melanoma cells, as P2RX7 levels drop in cells that have become resistant to therapy\u201d says Prof. Stephanie Kreis, co-head of the Signal Transduction group.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>&#8220;We could show that the concomitant induction of P2RX7 together with a joint inhibition of the MAPK signaling pathway and cell-cycle progression could represent a promising combination to prolong treatment effects and delay the onset of targeted drug resistance, which is a crucial clinical bottleneck in treatment of melanoma patients&#8221;, comments doctoral researcher Tijana Randic.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/T-Randic.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/T-Randic-300x200.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/T-Randic-1024x682.jpg 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/T-Randic-768x512.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/T-Randic-1536x1024.jpg 1536w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2023\/07\/T-Randic.jpg 2000w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/div>\n<\/div>\n\n\n\n<p>Read the full article <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37379213\/\">here\u00a0<\/a><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"<p>Ground-breaking research in cancer biology and immunology in the last decades has revolutionized the treatment of melanoma, a deadly form of skin cancer.<\/p>\n","protected":false},"author":52,"featured_media":1425,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[8],"news-topic":[23],"organisation":[100,29],"authorship":[52],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - 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