{"id":35891,"date":"2025-02-21T09:56:26","date_gmt":"2025-02-21T08:56:26","guid":{"rendered":"https:\/\/www.uni.lu\/fstm-en\/?post_type=events&#038;p=35891"},"modified":"2025-02-21T09:56:26","modified_gmt":"2025-02-21T08:56:26","slug":"physics-seminar-elda-hegmann","status":"publish","type":"events","link":"https:\/\/www.uni.lu\/fstm-en\/events\/physics-seminar-elda-hegmann\/","title":{"rendered":"Physics Seminar : Elda Hegmann"},"content":{"rendered":"\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><div class=\"wp-block-unilux-blocks-spacer is-spacer-size-md\"><\/div>\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"biocompatible-programmable-liquid-crystal-elastomer-based-inks-for-3d-printing-of-native-tissue\"\n    >\n<strong>Biocompatible Programmable Liquid Crystal Elastomer-based Inks for 3D Printing of Native Tissue<\/strong><\/h2>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n\n<h3 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"abstract\"\n    >\n<strong>Abstract<\/strong><\/h3>\n\n\n\n<p>Advanced Materials and Liquid Crystal Institute, Materials Science Graduate Program, Department of Biological Sciences, Brain Health Research Institute, Biomedical Sciences Program, Kent State University, Kent, USA.<\/p>\n\n\n\n<p>Biomaterials cover and are an integral part of tissue engineering and regenerative medicine fields. They are crucial to mimic endogenous tissue responses and help to eliminate high research costs and ethical concerns that come with 2D systems and animal models. Our research group focus on advanced manufacturing (AM) as a tool for the fabrication of cell scaffolds to find ideal biocompatible and biodegradable materials that fit the correct parameters for 3D printing and induce anisotropic cell behavior. Studying cells in 3D polymeric scaffolds has been advantageous strategy for growing cells in an environment that simulates the natural milieu and provides a realistic method for engineering tissues and in vitro experimentation. Our unique series of smectic (SmA) liquid crystal elastomers (LCEs), as 3D foams and now as 3D printed constructs, have shown to present unique internal morphologies and are non-cytotoxic, making them suitable as longitudinal and multi-responsive cell scaffolds. We have demonstrated how our LCEs are ideal for cell attachment, cell proliferation, cell anisotropy and most importantly cell maturation. During our group\u2019s scientific journey, we have also validated the importance of matching the mechanical properties, using cellulose nanocrystals (CNC), of these scaffolds to the cell lines of interest as an important key for tissue regeneration. I will present I will present three main examples of our work: 1) Study of material\u2019s anisotropy during extrusion printing and how this anisotropy transfers to cells and affects cell behaviour, 2) how our LCE-based bio-ink allows the 3D duplication of a highly complex brain structure generated from an animal model. Vascular tissue models are generated from fluorescently stained mouse tissue spatially imaged using confocal microscopy and subsequently processed to create a digital 3D model suitable for printing; and 3) a co-culturing system wherein neuroblastoma (SH-SY5Y) and oligodendrocyte (MO3.13) cell lines grow within both a caprolactone-based 3D elastomer and LCE scaffolding. We also demonstrated that LCE scaffolds promote maturation and differentiation of both cell lines alone, and in co-culturing fashion as they provide a suitable 3D in vitro environment to study myelination.<\/p>\n\n\n\n<p><strong>References<\/strong>:<\/p>\n\n\n\n<p>[1] S. Ustunel, <em>et al<\/em>., <em>Macromol. Rapid Comm<\/em>. <strong>2024<\/strong> 45 (11), 2300717<br>[2] S. Ustunel, <em>et al<\/em>., <em>J. Appl. Polym. Sci.<\/em> <strong>2023<\/strong>, 140 (20), e53883.<br>[3] M.E. Pr\u00e9v\u00f4t, <em>et al<\/em>., <em>Macromol. Biosci.<\/em> <strong>2023<\/strong>, 23, 2200343.<br>[4] G.A.R. Rohaley, and E. Hegmann, <em>Mater. Adv<\/em>. <strong>2022<\/strong>, 3 (14), 5725-5734.<br>[5] M.E. Pr\u00e9v\u00f4t, S. Ustunel, <em>et al<\/em>., <em>Crystals<\/em> <strong>2021<\/strong>, 11 (5), 523.<br>[6] S. Ustunel, <em>et al<\/em>., <em>Mater. Adv.<\/em> <strong>2021<\/strong>, 2, 464- 476.<br>[7] T.Mori, et al., <em>Macromol. Rapid Comm<\/em>. <strong>2020<\/strong>, 41 (5), 190058.<br>[8] M.E. Pr\u00e9v\u00f4t, S. Ustunel, et al., <em>Soft Matter<\/em>. <strong>2018<\/strong>, 14, 354-360.<br>[9] A. Sharma, et al., <em>Macromol. Bioscience<\/em>, <strong>2015<\/strong>, 15, 200-214; <em>Macromol. Bioscience<\/em>, <strong>2017<\/strong>, 17, 1600278.<\/p>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-sm\"><\/div>\n\n\n<h3 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"about-the-speaker\"\n    >\n<strong>About the speaker<\/strong><\/h3>\n\n\n\n<p><em>Elda Hegmann obtained her Ph.D. in 2003 at the Universit\u00e9 Laval in Qu\u00e9bec (Canada). After Postdoctoral research positions at Queen\u2019s University, University of Manitoba and at the National Research Council Canada (NRC). She then started her independent carrier as a Research Officer at the NRC in 2008 before moving to the USA to join the Advanced Materials and Liquid Crystal Institute at Kent State University in 2011 as an Assistant Professor. She later joined the Department of Biological Sciences at KSU and the Materials Science Graduate Program in 2017. Dr. Hegmann\u2019s research in biomaterials has produced several peer-reviewed articles and 4 patents. Dr Hegmann serves as the CEO on two start-up companies, TOREL LLC and Biostica LLC<\/em><\/p>\n<\/div><\/section>\n\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<p>In case you are unable to participate in person, we invite you to follow the seminar online: <\/p>\n\n\n\n<p>Meeting number: 2795 640 9997<br>Meeting password: BNeK6snYe37<\/p>\n\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list\"><li class=\"wp-block-unilux-blocks-custom-button\"    aria-disabled=\"false\"\n    >\n    <a\n        role=\"link\"\n        aria-disabled=\"false\"\n                    href=\"https:\/\/unilu.webex.com\/unilu\/j.php?MTID=mec4d6184a900e851b7b74cb5a77303b3\"\n                target=\"_self\"\n        class=\"btn btn--primary\"\n            >Webex<\/a>\n<\/li>\n<\/ul>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":201,"featured_media":35902,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","format":"standard","meta":{"featured_image_focal_point":{"x":0.44,"y":0.31},"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"event_start_date":"2025-03-11 10:00:00","event_end_date":"2025-03-11 11:00:00","event_speaker_name":"Elda Hegmann","event_speaker_link":"","event_is_online":true,"event_location":"Campus Limpertsberg - BSC 0.03","event_street":"162a, avenue de la Fa\u00efencerie","event_location_link":"","event_zip_code":"4365","event_city":"ESCH SUR ALZETTE","event_country":"Luxembourg"},"events-topic":[315],"events-type":[329,322],"organisation":[80,29],"authorship":[201,103,105,101,200],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Physics Seminar : Elda Hegmann - FSTM I Uni.lu<\/title>\n<meta name=\"description\" content=\"Advanced Materials and Liquid Crystal Institute, Materials Science Graduate Program, Department of Biological Sciences, Brain Health Research Institute,\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/fstm-en\/events\/physics-seminar-elda-hegmann\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Physics Seminar : Elda Hegmann\" \/>\n<meta property=\"og:description\" content=\"Advanced Materials and Liquid Crystal Institute, Materials Science Graduate Program, Department of Biological Sciences, Brain Health Research Institute,\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/fstm-en\/events\/physics-seminar-elda-hegmann\/\" \/>\n<meta property=\"og:site_name\" content=\"FSTM EN\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/fstm.uni.lu\/\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/4\/2025\/02\/Hegmann_Elda.png\" \/>\n\t<meta property=\"og:image:width\" content=\"775\" \/>\n\t<meta property=\"og:image:height\" content=\"759\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/fstm-en\/events\/physics-seminar-elda-hegmann\/\",\"url\":\"https:\/\/www.uni.lu\/fstm-en\/events\/physics-seminar-elda-hegmann\/\",\"name\":\"Physics Seminar : Elda Hegmann - 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