{"id":12175,"date":"2024-04-22T14:08:44","date_gmt":"2024-04-22T12:08:44","guid":{"rendered":"https:\/\/www.uni.lu\/fstm-en\/?post_type=events&#038;p=12175"},"modified":"2024-10-07T14:22:10","modified_gmt":"2024-10-07T12:22:10","slug":"physics-colloquium-silke-henkes","status":"publish","type":"events","link":"https:\/\/www.uni.lu\/fstm-en\/events\/physics-colloquium-silke-henkes\/","title":{"rendered":"Physics Colloquium"},"content":{"rendered":"\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list\"><\/ul>\n\n\n\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"active-tissue-models-with-feedback\"\n    >\nActive tissue models with feedback<\/h2>\n\n\n\n<p><strong>Abstract:<\/strong><\/p>\n\n\n\n<p>Epithelial tissues are one of the engines of development in multicellular organism, like during the gastrulation<br>process where the embryo turns inside out. This feat is performed by the active stresses generated by the<br>cytoskeleton, and cells coordinate their collective mechanics over large spatial distances.<br>My aim is to help unearth the general mechanism of activity and mechanics contributing to these processes. This<br>takes the form of microscopic models, composed of either particles or as a vertex model, where activity is added<br>as either a force crawling or as active stresses along cell junctions.<br>Even simple, uncorrelated polar active driving leads to an emergent correlation length that gives a<br>characteristically swirly spatiotemporal pattern to the cell flow. We confirm this with in-vitro epithelial tissues<br>and show that this mechanism also provides an explanation for the fingering fluctuations seen at cell sheet edges.<br>Feedback with the force exerted on the cells then leads to oscillations in confinement, part of what the \u2019selfalignment\u2019<br>class of models.<br>In the early stages of gastrulation in the chick embryo, tissue deformation is driven by convergent-extension flows<br>where tissue flows through active T1 transitions, against the applied stress, with active stresses along junctions.<br>We develop an active element where catch-bond dynamics of actomyosin allows the junction to work as an engine<br>that can contract to a single point under applied stress. At the tissue scale, such elements coupled to a vertex<br>model enable active T1 transitions, which each contribute a discrete negative strain amount, thus acting like<br>element of an active metamaterial. We are able to simulate a whole disordered tissue patch and match<br>convergence-extension patterns to experimental flows from primitive streak formation.<\/p>\n\n\n\n<p><strong>About the speaker:<\/strong><\/p>\n\n\n\n<p>Silke Henkes is a theoretical soft matter and biophysicist. She received her PhD on the<br>statistical mechanics of granular materials at Brandeis University with Bulbul<br>Chakraborty in 2008. After one postdoc focusing on granular matter at Leiden<br>University, she switched to active matter during a postdoc at Syracuse University with<br>Cristina Marchetti. Her focus in constructing microscopic models of active solids and<br>liquids at high density, especially models of epithelial cell sheets such as vertex<br>models. This has given rise to ongoing collaborative work with Biologists on<br>developmental systems including gastrulation and the cornea of the eye.<br>After Lecturer positions at the University of Aberdeen and the University of Bristol,<br>Silke Henkes has been Associate Professor at the Lorentz Institute, Leiden University<br>since 2022.<\/p>\n\n\n\n<p>This year, the physics colloquium has a&nbsp;<strong>new format<\/strong>:<\/p>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Onsite at Campus Limpertsberg,&nbsp;where you will have the opportunity to&nbsp;meet the speaker over the lunch. A catering is offered only to registered participants at 12:00 in the main BSC hall. Please <strong>register before 3 May 2024.<\/strong><\/li>\n<\/ul>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\"><\/li>\n<\/ul>\n\n\n\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\">Online \u2013 through&nbsp;<strong>Webex<\/strong>&nbsp;\u2013 to allow you to listen to the talk in case you are travelling or cannot make it on-site at Campus Limpertsberg. Meeting number (access code):2795 295 1560. Meeting password: CMyvSkV3n36 .\n<ul class=\"ulux-list\">\n<li class=\"ulux-list-item\"><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list\"><li class=\"wp-block-unilux-blocks-custom-button\"    aria-disabled=\"false\"\n    >\n    <a\n        role=\"link\"\n        aria-disabled=\"false\"\n                    href=\"http:\/\/ulsurvey.uni.lu\/index.php\/677698?lang=en\"\n                target=\"_blank\"\n        class=\"btn btn--primary\"\n            >Lunch registration<\/a>\n<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list\"><li class=\"wp-block-unilux-blocks-custom-button\"    aria-disabled=\"false\"\n    >\n    <a\n        role=\"link\"\n        aria-disabled=\"false\"\n                    href=\"https:\/\/unilu.webex.com\/unilu\/j.php?MTID=m36b32b9cc489463f394c150c391331a9\"\n                target=\"_blank\"\n        class=\"btn btn--primary\"\n            >Webex link<\/a>\n<\/li>\n<\/ul>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":105,"featured_media":12178,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"event_start_date":"2024-05-08 13:00:00","event_end_date":"2024-05-08 14:00:00","event_speaker_name":"Associate Professor Silke Henkes","event_speaker_link":"","event_is_online":false,"event_location":"BS 0.03 Campus Limpertsberg","event_street":"162a, avenue de la Fa\u00efencerie","event_location_link":"https:\/\/www.uni.lu\/en\/about\/campuses\/limpertsberg-campus\/","event_zip_code":"1511","event_city":"Luxembourg","event_country":"Luxembourg"},"events-topic":[315],"events-type":[329,322],"organisation":[80,29],"authorship":[105,103,101,201],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - 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