{"id":2146,"date":"2023-04-04T10:18:43","date_gmt":"2023-04-04T10:18:43","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/fr\/news\/how-genes-brain-characteristics-and-intelligence-are-connected\/"},"modified":"2023-04-04T10:18:43","modified_gmt":"2023-04-04T10:18:43","slug":"how-genes-brain-characteristics-and-intelligence-are-connected","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/fr\/news\/how-genes-brain-characteristics-and-intelligence-are-connected\/","title":{"rendered":"How genes, brain characteristics and intelligence are connected"},"content":{"rendered":"<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><p>Genes influence different structures and the function of the brain. These in turn explain differences in behaviour. Analysing all three aspects at once is a challenge \u2013 and has been achieved for the first time.<\/p><p>Intelligence is partly heritable. There are studies that show that certain genetic variations are linked to better performance in intelligence tests. Other studies show that a variety of brain characteristics, such as network efficiency, are related to intelligence. Researchers from the Ruhr University Bochum and the University of Luxembourg now analysed simultaneously gene analyses, magnetic resonance imaging and intelligence tests to demonstrate which brain characteristics form the link between genes and behaviour.<\/p><p>The study, published in the journal \u201cHuman Brain Mapping\u201d, was designed by <a href=\"https:\/\/wwwfr.uni.lu\/recherche\/fhse\/dbcs\/people\/robert_kumsta\" target=\"_self\" title=\"Robert Kumsta\" rel=\"noopener\">Robert Kumsta<\/a>, professor in Biopsychology at the <a href=\"https:\/\/wwwfr.uni.lu\/fhse\" target=\"_self\" title=\"Faculty of Humanities, Education and Social Sciences\" rel=\"noopener\">Faculty of Humanities, Education and Social Sciences<\/a> of the University of Luxembourg, together with Dorothea Metzen at Ruhr University Bochum and Dr. Erhan Gen\u00e7 at the Leibniz Research Centre for Working Environment and Human Factors.<\/p>\n<h3 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"genes-brain-behaviour-a-unique-data-set\"\n    >\nGenes, brain, behaviour \u2013 a unique data set<\/h3>\n<p>The team included 557 persons aged between 18 and 75 years in the study. Using saliva samples, they analysed which individuals possessed how many gene variations associated with high intelligence. \u201cThere are thousands of genes that contribute to intelligence,\u201d explains Dorothea Metzen. \u201cWe calculated a summary score for each person that reflects the genetic predisposition for high intelligence.\u201d<\/p><p>In addition, all participants took part in brain scans, which the researchers used to determine not only the thickness and surface area of the cerebral cortex, but also how efficiently the structural and functional networks in the brain are organised. All participants also completed an intelligence test. \u201cThe broadness and detailed recording of various data in this study is, as far as I am aware, unprecedented,\u201d emphasises Erhan Gen\u00e7. \u201cFor the first time, we looked at the triad of genes, different brain characteristics and behavioural traits as a whole.\u201d<\/p>\n<h3 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"interplay-of-genes-brain-characteristics-and-intelligence-in-a-few-brain-regions\"\n    >\nInterplay of genes, brain characteristics and intelligence in a few brain regions<\/h3>\n<p>When the team only looked at the connection between genetic variations and brain characteristics \u2013 that is, disregarding intelligence test results \u2013 they found numerous associations in many regions distributed across the entire brain. Significantly fewer associations were apparent when the researchers investigated which brain characteristics were associated with intelligence test performance.<\/p><p>When they considered all three parameters at once \u2013 genes, brain characteristics and intelligence test performance \u2013 an association was only found in few brain areas in the frontal, parietal and visual cortex. This means that there are only specific areas in the brain where gene variations influence brain characteristics, and these characteristics simultaneously affect intelligence. The decisive brain characteristics were the size of the brain surface and the efficiency of structural connectivity. The researchers found very few such connections between genes, brain and behaviour when they examined the thickness of the cerebral cortex and the efficiency of functional connectivity.<\/p>\n<h3 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"method-also-transferable-to-other-areas\"\n    >\nMethod also transferable to other areas<\/h3>\n<p>The researchers hope this method can be applied to larger cohorts, or to other areas, such the impact of age. \u201cWe will continue investigating the contribution of genetic variability to different traits, especially in the context of stress research,\u201d states Robert Kumsta. \u201d Here, we focus on the interplay between genes and stress exposure to understand how different types of stress contribute to mental health problems.\u201d<\/p><p>Scientists at the Humboldt-Universit\u00e4t Berlin, the Central Institute of Mental Health in Mannheim, the Medical School Hamburg were also involved in the study.<\/p><p>Erhan Gen\u00e7, Dorothea Metzen, Christoph Fraenz, Caroline Schl\u00fcter, Manuel C. Voelkle, Larissa Arning, Fabian Streit, Huu Phuc Nguyen, Onur G\u00fcnt\u00fcrk\u00fcn, Sebastian Ocklenburg, Robert Kumsta: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hbm.26286\" target=\"_blank\" title=\"Structural architecture and brain network efficiency link polygenic scores to intelligence\" rel=\"noopener\">Structural architecture and brain network efficiency links polygenic scores to intelligence<\/a>, in: Human Brain Mapping, 2023, DOI: 10.1002\/hbm.26286<\/p><p>This article was first published on <a href=\"https:\/\/www.ruhr-uni-bochum.de\/de\" target=\"_blank\" title=\"Ruhr Universit\u00e4t Bochum\" rel=\"noopener\">the website of the Ruhr Universit\u00e4t Bochum<\/a>.<\/p>\n<h5 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"photo-ruhr-universitat-bochum\"\n    >\n\u00a9 Photo: Ruhr Universit\u00e4t Bochum<\/h5>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>Genes influence different structures and the function of the brain. These in turn explain differences in behaviour. Analysing all three aspects at once is a challenge \u2013 and has been achieved for the first time.<\/p>\n","protected":false},"author":0,"featured_media":0,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[4,3],"news-topic":[],"organisation":[147,226],"authorship":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How genes, brain characteristics and intelligence are connected - Universit\u00e9 du Luxembourg<\/title>\n<meta name=\"description\" content=\"Genes influence different structures and the function of the brain. 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