{"id":1116,"date":"2020-10-27T08:32:34","date_gmt":"2020-10-27T08:32:34","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/"},"modified":"2020-10-27T08:32:34","modified_gmt":"2020-10-27T08:32:34","slug":"age-resistant-quiescent-stem-cells-support-muscle-regeneration","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/","title":{"rendered":"Age-resistant quiescent stem cells support muscle regeneration"},"content":{"rendered":"<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><p>Researchers from the Computational Biology group at the University of Luxembourg&rsquo;s Luxembourg Centre for Systems Biology (LCSB) participated in an international study focusing on adult stem cells in muscle tissue. The results of this collaboration highlighted the existence of two different types of\u00a0quiescent stem-cell states\u00a0with distinct properties. Thanks to the implementation of a new computational method, the researchers were able to elucidate some of the molecular mechanisms involved in the observed\u00a0stem-cell heterogeneity, and to restore stem cell regenerative function in old age. Their\u00a0findings, recently published in\u00a0<i>Nature Cell Biology<\/i>,\u00a0showed that the diversity and regenerative properties of stem cells resist ageing more than previously anticipated, ensuring\u00a0prolonged\u00a0survival and\u00a0supporting\u00a0tissue regeneration.<\/p><p>Adult stem cells are undifferentiated cells, found throughout the body, that\u00a0have the\u00a0the\u00a0ability to self-renew and\u00a0can differentiate into\u00a0all\u00a0cell types, helping\u00a0regenerate damaged tissues.\u00a0Stem cell ageing is one of the causes of the decline observed in tissue regeneration\u00a0over time, but the underlying mechanisms remain largely unknown. \u201cThe possibility of delaying or reversing stem-cell functional decline is one of the most fascinating challenges in regenerative medicine,\u201d explains <a href=\"https:\/\/wwwfr.uni.lu\/lcsb\/people\/antonio_del_sol_mesa\" target=\"_self\" title=\"\" rel=\"noopener\">Prof. Antonio Del Sol<\/a>, head of the <a href=\"https:\/\/wwwfr.uni.lu\/lcsb\/research\/computational_biology\" target=\"_blank\" title=\"\" rel=\"noopener\">Computational Biology group<\/a> at the LCSB.<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"two-stem-cell-states-with-different-roles\"\n    >\nTwo stem cell states with different roles<\/h2>\n<p>Adult stem cells\u00a0are quiescent for most of their life: they stay dormant for prolonged periods and only activate in response to injury. They then multiply and acquire distinct fates, some forming new muscles fibres while others replenish the stem-cell pool. Recent studies suggested that the\u00a0quiescent\u00a0stem cell\u00a0population\u00a0is\u00a0heterogeneous, but the role of this heterogeneity in tissue repair and how it evolves throughout life remain unclear. Researchers from the LCSB and colleagues from Spain, Italy and USA collaborated to investigate these issues in mice, from early neonatal stages to geriatric age, and through innovative computational methods.<\/p><p>They identified\u00a0two quiescent stem-cell states\u00a0in undisturbed\u00a0skeletal muscle\u00a0that\u00a0are distinguished by their relative expression of\u00a0a specific gene called\u00a0CD34. Quiescent stem cells expressing high CD34 levels are set to self-renew upon injury, keeping the\u00a0genuine\u00a0hallmarks of stem cells (genuine state), whereas those expressing low levels are primed to\u00a0differentiate into muscle cells (primed state).<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"preservation-of-stem-cell-diversity-through-old-age\"\n    >\nPreservation of stem cell diversity through old age<\/h2>\n<p>The researchers further showed that the genuine stem cell state is preserved into old age: old genuine stem cells performed as well as young counterparts during muscle regeneration\u00a0<i>in vivo<\/i>. Nonetheless, in extreme old age, these stem-cells undergo a steep functional decline and acquire\u00a0traits\u00a0characteristic of primed stem cells. If this final change likely explains the sharp deterioration in muscle regeneration in geriatric age, these results are also unexpected: diversity and regenerative properties of stem cells resist ageing more than previously anticipated.<\/p><p>Understanding the underlying molecular mechanisms<strong>\u00a0<\/strong><\/p><p>To better understand how stem cell heterogeneity evolves over time, the researchers explored the mechanisms involved by using computational and mathematical modelling. They identified a molecular pathway that plays a role in maintaining the two quiescent stem cell states. First, the activity of a specific transcription factor \u2013 called FoxO \u2013 is required to preserve the genuine stem cell state.\u00a0Conversely, FoxO inactivation deteriorates the genuine state,causing\u00a0stem cells to acquire traits of the primed state, as seen in extreme old age. It suggests that long-lived quiescent stem cells primarily rely on FoxO signalling to preserve diversity and stemness.<\/p><p>Exploring further up the signalling pathway thanks to a\u00a0new computational method, the researchers found that two molecules \u2013 Igf and Akt \u2013 impact FoxO transcription factors and regulate the stem cell states.<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"countering-age-dependent-muscle-atrophy\"\n    >\nCountering age-dependent muscle atrophy<\/h2>\n<p>This study\u00a0highlights\u00a0loss of heterogeneity in long-lived stem cells as a driver of regenerative failure with ageing.Understanding how to preserve the stem cell fraction endowed with the highest regenerative properties in old muscle will be critical to enhancing muscle regeneration, particularly at geriatric age.<\/p><p>\u201cThe identification of the IGF-1\/Akt\/FoxO signalling pathway and of its role in maintaining the heterogeneity of quiescent stem cells could help uncover ways to activate stem cells to repair muscle,\u201d emphasizes Prof. Del Sol. \u201cTargeting these molecules could for example promote stemness and constitute a promising strategy to rejuvenate geriatric genuine stem cells, with beneficial consequences for regeneration after injury.\u201d<\/p><p>&#8212;<\/p><p>Reference: <i>Nat Cell Biol<\/i><\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>Researchers from the Computational Biology group at the University of Luxembourg&rsquo;s Luxembourg Centre for Systems Biology (LCSB) participated in an international study focusing on adult stem cells in muscle tissue. The results of this collaboration highlighted the existence of two different types of\u00a0quiescent stem-cell states\u00a0with distinct properties. Thanks to the implementation of a new computational method, the researchers were able to elucidate some of the molecular mechanisms involved in the observed\u00a0stem-cell heterogeneity, and to restore stem cell regenerative function in old age. Their\u00a0findings, recently published in\u00a0Nature Cell Biology,\u00a0showed that the diversity and regenerative properties of stem cells resist ageing more than previously anticipated, ensuring\u00a0prolonged\u00a0survival and\u00a0supporting\u00a0tissue regeneration.<\/p>\n","protected":false},"author":0,"featured_media":0,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[4,3],"news-topic":[19],"organisation":[202,226],"authorship":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Age-resistant quiescent stem cells support muscle regeneration - Universit\u00e9 du Luxembourg<\/title>\n<meta name=\"description\" content=\"Researchers from the Computational Biology group at the University of Luxembourg&#039;s Luxembourg Centre for Systems Biology (LCSB) participated in an international study focusing on adult stem cells in muscle tissue. The results of this collaboration highlighted the existence of two different types of\u00a0quiescent stem-cell states\u00a0with distinct properties. Thanks to the implementation of a new computational method, the researchers were able to elucidate some of the molecular mechanisms involved in the observed\u00a0stem-cell heterogeneity, and to restore stem cell regenerative function in old age. Their\u00a0findings, recently published in\u00a0Nature Cell Biology,\u00a0showed that the diversity and regenerative properties of stem cells resist ageing more than previously anticipated, ensuring\u00a0prolonged\u00a0survival and\u00a0supporting\u00a0tissue regeneration.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Age-resistant quiescent stem cells support muscle regeneration\" \/>\n<meta property=\"og:description\" content=\"Researchers from the Computational Biology group at the University of Luxembourg&#039;s Luxembourg Centre for Systems Biology (LCSB) participated in an international study focusing on adult stem cells in muscle tissue. The results of this collaboration highlighted the existence of two different types of\u00a0quiescent stem-cell states\u00a0with distinct properties. Thanks to the implementation of a new computational method, the researchers were able to elucidate some of the molecular mechanisms involved in the observed\u00a0stem-cell heterogeneity, and to restore stem cell regenerative function in old age. Their\u00a0findings, recently published in\u00a0Nature Cell Biology,\u00a0showed that the diversity and regenerative properties of stem cells resist ageing more than previously anticipated, ensuring\u00a0prolonged\u00a0survival and\u00a0supporting\u00a0tissue regeneration.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/\" \/>\n<meta property=\"og:site_name\" content=\"UNI FR\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uni.lu\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/11\/2020\/10\/age_resistant_quiescent_stem_cells_support_muscle_regeneration.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"Age-resistant quiescent stem cells support muscle regeneration\",\"datePublished\":\"2020-10-27T08:32:34+00:00\",\"dateModified\":\"2020-10-27T08:32:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/\"},\"wordCount\":697,\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/fr\/#organization\"},\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/\",\"url\":\"https:\/\/www.uni.lu\/fr\/news\/age-resistant-quiescent-stem-cells-support-muscle-regeneration\/\",\"name\":\"Age-resistant quiescent stem cells support muscle regeneration - Universit\u00e9 du Luxembourg\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/fr\/#website\"},\"datePublished\":\"2020-10-27T08:32:34+00:00\",\"dateModified\":\"2020-10-27T08:32:34+00:00\",\"description\":\"Researchers from the Computational Biology group at the University of Luxembourg's Luxembourg Centre for Systems Biology (LCSB) participated in an international study focusing on adult stem cells in muscle tissue. The results of this collaboration highlighted the existence of two different types of\u00a0quiescent stem-cell states\u00a0with distinct properties. Thanks to the implementation of a new computational method, the researchers were able to elucidate some of the molecular mechanisms involved in the observed\u00a0stem-cell heterogeneity, and to restore stem cell regenerative function in old age. 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