{"id":15763,"date":"2024-07-15T10:40:03","date_gmt":"2024-07-15T08:40:03","guid":{"rendered":"https:\/\/www.uni.lu\/fhse-en\/?post_type=core-researches&p=15763"},"modified":"2024-08-13T07:51:12","modified_gmt":"2024-08-13T05:51:12","slug":"adverse-childhood-experience-and-stress-regulation","status":"publish","type":"core-researches","link":"https:\/\/www.uni.lu\/fhse-en\/core-researches\/adverse-childhood-experience-and-stress-regulation\/","title":{"rendered":"Adverse childhood experience and stress regulation"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":295,"featured_media":0,"template":"","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"rp_acronym":"Adverse childhood experience and stress regulation","rp_abstract":"This project focused on the molecular and genetic mechanisms underlying the effects of early life stress and adversity on physical and mental health outcomes in later life.\nWe demonstrated that individuals with a history of childhood adversity exhibited altered hormonal and gene expression in response to stress, particularly in genes involved in the regulation of inflammation and immune response. Furthermore, utilising a proteomics approach, we found that the experience of adversity in childhood was associated with changes in the expression of proteins related to mitochondrial function, suggesting a potential link between early-life stress and mitochondrial dysfunction.\n\n","rp_start_date":"2019-05-01 10:36:53","rp_duration":48,"rp_main_funder":"DFG","rp_other_funders":[],"rp_external_partners":[],"rp_keywords":["Childhood Adversity","Physical Health","Mental Health"],"rp_members":[{"name":"Robert KUMSTA","isPI":true,"isExternal":false,"featuredImageUrl":"https:\/\/www.uni.lu\/en\/person-image\/NTAwNDM5NzdfX1JvYmVydCBLVU1TVEE=","detailsPageUrl":"https:\/\/www.uni.lu\/fhse-en\/people\/robert-kumsta\/","id":"50043977"}]},"research-project-status":[272],"research-project-type":[270],"field-of-interest":[440],"organisation":[150,147,163],"authorship":[295,296,111,107,109],"acf":[],"_links":{"self":[{"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/core-researches\/15763"}],"collection":[{"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/core-researches"}],"about":[{"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/types\/core-researches"}],"author":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/users\/295"}],"version-history":[{"count":1,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/core-researches\/15763\/revisions"}],"predecessor-version":[{"id":15766,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/core-researches\/15763\/revisions\/15766"}],"wp:authorship":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/users\/295"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/users\/296"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/users\/111"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/users\/107"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/users\/109"}],"wp:attachment":[{"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/media?parent=15763"}],"wp:term":[{"taxonomy":"research-project-status","embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/research-project-status?post=15763"},{"taxonomy":"research-project-type","embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/research-project-type?post=15763"},{"taxonomy":"field-of-interest","embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/field-of-interest?post=15763"},{"taxonomy":"organisation","embeddable":true,"href":"https:\/\/www.uni.lu\/fhse-en\/wp-json\/wp\/v2\/organisation?post=15763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}