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Pain is a highly personal experience, influenced strongly by all kinds of factors, including psychological factors such as stress, emotions, attention, and expectations. For example, a negative mood may exacerbate pain, whereas a good mood may alleviate pain. Likewise, worrying about pain may make it worse, while positive expectations may provide relief. These types of psychological pain modulation are mediated by dedicated pathways in the central nervous system, the so-called “descending pain control” system. This system consists of a network of brain regions that can send signals down via the brainstem and spinal cord, to either facilitate or inhibit upcoming nociceptive signals.https://www.uni.lu/wp-content/uploads/sites/2/2026/03/03112240/FHSE_SM-Profile_1600x1600px-scaled.jpg25602560