{"id":7522,"date":"2018-11-30T14:24:45","date_gmt":"2018-11-30T14:24:45","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/en\/news\/altered-microbiome-post-caesarean-section-impacts-babys-immune-system\/"},"modified":"2018-11-30T14:24:45","modified_gmt":"2018-11-30T14:24:45","slug":"altered-microbiome-post-caesarean-section-impacts-babys-immune-system","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/en\/news\/altered-microbiome-post-caesarean-section-impacts-babys-immune-system\/","title":{"rendered":"Altered microbiome post caesarean section impacts baby\u2019s immune system"},"content":{"rendered":"

Together with colleagues from Sweden and Luxembourg, scientists from the Luxembourg Centre for Systems Biomedicine (LCSB)<\/a> of the University of Luxembourg have observed that, during a natural vaginal birth, specific bacteria from the mother\u2019s gut are passed on to the baby and stimulate the baby\u2019s immune responses.<\/p>

This transmission is impacted in children born by caesarean section. \u201cThis may explain why, epidemiologically speaking, caesarean-born children suffer more frequently from chronic, immune system-linked diseases compared to babies born vaginally,\u201d says the head of the study Associate Prof. Paul Wilmes<\/a>. His team has now published its results in the open access journal Nature Communications (DOI: 10.1038\/s41467-018-07631-x)<\/a>.<\/p>

Humans are born germ-free. Yet, birth is normally the time when vitally important bacteria start to colonise the body including the gut, skin and lungs. Researchers have long suspected that this early colonisation sets the course for one\u2019s later health.<\/p>

It could be, however, that a caesarean section prevents certain bacteria, ordinarily interacting with the baby\u2019s immune system, from being passed on from the mother to the new-born. Paul Wilmes, head of the Eco-Systems Biology research group at the LCSB, and his colleagues have now found the first evidence of this in a study of new-borns \u2013 half of whom were delivered by caesarean section.<\/p>

Wilmes reports: \u201cWe find specific bacterial substances that stimulate the immune system in vaginally born babies. In contrast, the immune stimulation in caesarean children is much lower either because the bacterial triggers are present at much lower levels or other bacterial substances hamper these initial immune reactions to happen.\u201d<\/p>

\n \n\"\"\n <\/figure>

<\/p>

This bacterial coloniser-immune system link \u2013 together with other factors \u2013 could explain why caesarean section babies are statistically more prone to develop allergies, chronic inflammatory diseases and metabolic diseases. \u201cIt could be that the immune system of these children is set on a different path early on,\u201d suggests Paul Wilmes. \u201cWe now want to further investigate this link mechanistically and find ways by which we might replace the lacking maternal bacterial strains in caesarean-born babies, e.g. by administering probiotics.\u201d<\/p>

\u201cOf course, it is already clear that we should not intervene too strongly in the birth process. Babies should only be delivered by caesarean section when it is medically necessary\u201d, Paul Wilmes stresses. \u201cWe need to be aware that, in doing so, we are apparently intervening massively in the natural interactions between humans and bacteria.\u201d<\/p>

<\/p>

To know more, check out the “Behind the paper” article<\/a> on the website of Nature Research Microbiology Community.<\/p>

—<\/p>

The study was supported by the Fondation Andr\u00e9 et Henriette Losch as well as by grants from the ATTRACT, CORE and AFR programmes of the Luxembourg National Research Fund (FNR)<\/a>. Additional funds were provided by the University of Luxembourg. Sample collection, processing and storage were co-funded by the Integrated BioBank of Luxembourg<\/a> under the Personalised Medicine Consortium Diabetes programme.<\/p>

Pictures<\/strong>: \u00a9 Linda Wampach<\/p>

Bibliography<\/strong>: Linda Wampach, Anna Heintz-Buschart, Jo\u00eblle V. Fritz, Javier Ramiro-Garcia, Janine Habier, Malte Herold, Shaman Narayanasamy, Anne Kaysen, Angela H. Hogan, Lutz Bindl, Jean Bottu, Rashi Halder, Conny Sj\u00f6qvist, Patrick May, Anders F. Andersson, Carine de Beaufort and Paul Wilmes, Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential, Nature Communications, 30 November 2018.<\/p>

DOI: 10.1038\/s41467-018-07631-x<\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"

Together with colleagues from Sweden and Luxembourg, scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have observed that, during a natural vaginal birth, specific bacteria from the mother\u2019s gut are passed on to the baby and stimulate the baby\u2019s immune responses.<\/p>\n","protected":false},"author":0,"featured_media":7523,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[11,10],"news-topic":[26],"organisation":[209,226,233],"authorship":[],"acf":[],"yoast_head":"\nAltered microbiome post caesarean section impacts baby\u2019s immune system - 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