{"id":7480,"date":"2018-09-11T09:53:43","date_gmt":"2018-09-11T09:53:43","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/"},"modified":"2018-09-11T09:53:43","modified_gmt":"2018-09-11T09:53:43","slug":"better-understanding-of-how-colon-cancer-develops-and-progresses","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/","title":{"rendered":"Better understanding of how colon cancer develops and progresses"},"content":{"rendered":"<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><p>Researchers from the University of Luxembourg have discovered a molecular mechanism that is responsible for the spread of cancer cells in the body and the development of metastases in patients with colon cancer. Their findings could help to develop treatments that inhibit tumor growth.<\/p><p>Colorectal cancer (CRC) is among the most prevalent cancer types worldwide, with an estimated 1.3 million new cases and almost 700\u2019000 deaths per year. The vast majority of CRC-related deaths can be attributed to metastatic spreading of the disease. Therefore, it is of utmost clinical relevance to understand the biology that underlies cancer progression and metastasis initiation.<\/p>\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"first-step-for-the-development-of-novel-therapeutic-strategies\"\n    >\nFirst step for the development of novel therapeutic strategies<\/h2>\n<p>The scientists from the <a href=\"https:\/\/wwwen.uni.lu\/recherche\/fstm\/dlsm\/research_areas\/molecular_disease_mechanisms\" target=\"_self\" title=\"Molecular Disease Mechanism (MDM)\" rel=\"noopener\">Molecular Disease Mechanisms (MDM)<\/a> group at the University of Luxembourg compared cancer cells derived from primary, i.e. initial, tumors to metastatic cells from the same patient. The researchers found that a group of small molecules, namely the miR-371~373 cluster, is responsible for the regulation of colon cancer metastasis. In an interdisciplinary approach, combining experimental and computational analyses, the research team observed that the miR-371~373 cluster is deactivated in a specific population of very aggressive, fast-growing cancer cells. After the scientists reactivated the cluster in a complex series of experiments, the growth of the metastatic cells slowed down significantly. \u201cCancer is a really complex disease. While our results are just one piece of the puzzle, they clearly contribute to a better understanding of tumor initiation and metastasis and might be an important first step for the development of novel therapeutic strategies,\u201d said Dr. Pit Ullmann, the lead author of the <a href=\"http:\/\/cancerres.aacrjournals.org\/content\/78\/14\/3793.long\" target=\"_blank\" title=\"Study published in Cancer Research\" rel=\"noopener\">study that was published in the prestigious journal \u201cCancer Research\u201d<\/a>.<\/p><p>Together with national and international collaborators from the RWTH University Hospital Aachen, the <a href=\"https:\/\/www.ibbl.lu\" target=\"_blank\" title=\"Integrated BioBank of Luxembourg (IBBL)\" rel=\"noopener\">Integrated BioBank of Luxembourg (IBBL)<\/a>, the Centre d&#8217;Investigation et d&#8217;\u00c9pid\u00e9miologie Clinique (CIEC), the Laboratoire National de Sant\u00e9 (LNS), and several hospitals around the country, especially the Centre Hospitalier Emile Mayrisch (CHEM), the researchers were able to validate their results in patient samples from a large Luxembourgish colon cancer collection. \u201cThis kind of study is only possible if several groups with different expertise collaborate. Our partners have been very important throughout the project in order to assess the clinical relevance of our findings in colorectal cancer patients,\u201d commented Dr. Elisabeth Letellier, principal investigator of the study.<\/p><p>The large study was supported by the <a href=\"https:\/\/www.fnr.lu\" target=\"_self\" title=\"Fonds National de la Recherche (FNR)\" rel=\"noopener\">Luxembourg National Research Fund (FNR)<\/a> and the Fondation Cancer. \u201cCompetitive cancer research heavily relies on state-of-the-art techniques and the availability of high quality patient samples. The concerted effort of different groups, the interdisciplinary approach, and especially the financial support by the FNR, the Fondation Cancer, and other funding institutions were crucial for the successful completion of this project,\u201d said Prof. Serge Haan, the head of the MDM group.<\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>Researchers from the University of Luxembourg have discovered a molecular mechanism that is responsible for the spread of cancer cells in the body and the development of metastases in patients with colon cancer. Their findings could help to develop treatments that inhibit tumor growth.<\/p>\n","protected":false},"author":0,"featured_media":7481,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[11,10],"news-topic":[26],"organisation":[103,32,233],"authorship":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Better understanding of how colon cancer develops and progresses - University of Luxembourg<\/title>\n<meta name=\"description\" content=\"Researchers from the University of Luxembourg have discovered a molecular mechanism that is responsible for the spread of cancer cells in the body and the development of metastases in patients with colon cancer. Their findings could help to develop treatments that inhibit tumor growth.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Better understanding of how colon cancer develops and progresses\" \/>\n<meta property=\"og:description\" content=\"Researchers from the University of Luxembourg have discovered a molecular mechanism that is responsible for the spread of cancer cells in the body and the development of metastases in patients with colon cancer. Their findings could help to develop treatments that inhibit tumor growth.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/\" \/>\n<meta property=\"og:site_name\" content=\"UNI EN\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uni.lu\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2018\/09\/better_understanding_of_how_colon_cancer_develops_and_progresses.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"Better understanding of how colon cancer develops and progresses\",\"datePublished\":\"2018-09-11T09:53:43+00:00\",\"dateModified\":\"2018-09-11T09:53:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/\"},\"wordCount\":458,\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2018\/09\/better_understanding_of_how_colon_cancer_develops_and_progresses.jpg\",\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/\",\"url\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/\",\"name\":\"Better understanding of how colon cancer develops and progresses - University of Luxembourg\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/better-understanding-of-how-colon-cancer-develops-and-progresses\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2018\/09\/better_understanding_of_how_colon_cancer_develops_and_progresses.jpg\",\"datePublished\":\"2018-09-11T09:53:43+00:00\",\"dateModified\":\"2018-09-11T09:53:43+00:00\",\"description\":\"Researchers from the University of Luxembourg have discovered a molecular mechanism that is responsible for the spread of cancer cells in the body and the development of metastases in patients with colon cancer. 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