{"id":40613,"date":"2022-12-19T15:58:00","date_gmt":"2022-12-19T14:58:00","guid":{"rendered":"https:\/\/www.uni.lu\/en\/?post_type=news&p=40613"},"modified":"2025-02-19T10:30:00","modified_gmt":"2025-02-19T09:30:00","slug":"how-damaged-cells-inhibit-muscle-regeneration-over-lifetime","status":"publish","type":"news","link":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/","title":{"rendered":"How damaged cells inhibit muscle regeneration over lifetime"},"content":{"rendered":"\n
\n

Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature<\/i> in December.<\/p>\n\n\n\n

Stem cells, senescence and tissue renewal<\/strong><\/p>\n\n\n\n

In the human body, stem cells reside in what scientists call a niche, an area of a tissue that provides a specific microenvironment. Within that niche, other cells interact with the stem cells and can activate them, promoting tissue regeneration. This process requires a coordinated communication between different type of cells but the mechanisms involved are not well understood.<\/p>\n\n\n\n

As regenerative functions decline during ageing, while senescent cells accumulate, a group of researchers from Spain, China, Japan, USA and Luxembourg decided to explore the role of senescence in tissue regeneration. \u201cOur objective was to study senescent cells in vivo<\/i>, to understand how they emerge and how they affect the repair process of tissues throughout life,\u201d explains Prof. Antonio Del Sol<\/a>, head of the Computational Biology group<\/a> at the LCSB. \u201cFor this purpose, we used a combination of experimental work with mice, conducted by colleagues at Pompeu Fabra University<\/a> and at the Guangzhou Institutes of Biomedicine and Health<\/a>, and of computational methods developed by my teams at the LCSB<\/a> and the CIC bioGUNE-BRTA<\/a>.\u201d<\/p>\n\n\n\n

Injury and age are detrimental to muscle regeneration<\/strong><\/p>\n\n\n\n

Focusing on muscle tissue in mice, the researchers first observed that senescent cells appear in muscles when they get damaged or with age. Their results show that both injury and ageing induce the accumulation of high levels of oxidative stress and DNA damage in a subset of cells, driving these cells towards senescence.<\/p>\n\n\n\n

The experiments conducted in the lab also demonstrated that the group of cells that become senescent are part of the regenerative niche surrounding stem cells. The presence of these senescent cells in the niche in turn represses muscle regeneration at all stages of life. To further illustrate the impact of senescent cells, the scientists could accelerate regeneration in young mice and rejuvenate muscles of old mice by removing senescent cells from the tissue.<\/p>\n\n\n\n

\u201cNow that we knew why senescent cells emerge and that they have such a direct effect on tissue repair, we wanted to better understand what senescence is exactly and which mechanisms are involved,\u201d points Prof. Pura Mu\u00f1oz-C\u00e1noves, corresponding author of the article, ICREA Professor at the Pompeu Fabra University in Barcelona and a Principal Investigator at the Altos Labs San Diego Institute of Sciences<\/a>.<\/p>\n\n\n\n

An atlas of senescent cells highlighting common hallmarks<\/strong><\/p>\n\n\n\n

The researchers generated the first atlas of senescent cells in vivo<\/i>, unravelling three major senescent cell populations in regenerating muscle. On top of identifying these different types of senescent cells, present in both mice and humans, the team also searched for common traits across these cells. Their analyses showed that senescent cells are molecularly diverse but share two major hallmarks.<\/p>\n\n\n\n

\u201cWhen they become senescent, cells still conserve part of their identity. Some of their traits correspond to their initial cell type. This cell-of-origin memory explains why senescent cells appear so heterogeneous,\u201d details Prof. Del Sol. \u201cHowever, when looking more closely, we found two universal senescence markers: inflammation and fibrosis.\u201d<\/p>\n\n\n\n

By investigating, through computational methods, which global functions are upregulated across all senescent cells present in muscles, the researchers uncovered these two core hallmarks, providing the first molecular and functional definition of senescent cells in vivo<\/i>.<\/p>\n\n\n\n

Neutralising senescent cells to promote regeneration<\/strong><\/p>\n\n\n\n

The identification of these common characteristics was key to understand by which mechanisms senescent cells impair tissue regeneration. The scientists showed that senescent cells present in the regenerative niche act through the secretion of pro-inflammatory and pro-fibrotic factors. The molecules they produce affect the stem cells nearby, inhibiting their proliferation and impairing regeneration.<\/p>\n\n\n\n

\u201cAfter an injury, some muscles cells turn senescent and create an aged-like microenvironment. Their secretions mirror the inflammation associated with ageing, even in young, injured mice. We call it inflammaging,\u201d explains Antonio Del Sol. \u201cThis is the mechanism by which they diminish stem cell function and arrest tissue repair.\u201d<\/p>\n\n\n\n

Further computational analyses identified lipid-transport gene CD36 as a possible way to regulate the impact of senescent cells. By targeting this specific gene, the researchers could improve muscle regeneration in both young and old mice while reducing inflammation and fibrosis. \u201cFuture studies are now needed to confirm CD36 as a new senomorphic target in vivo<\/i>,\u201d indicates Prof. Mu\u00f1oz-C\u00e1noves.<\/p>\n\n\n\n

In conclusion, the elimination of senescent cell or the reduction of the inflammatory factors they secrete can have beneficial consequences. As senescent cells accumulate in human muscles just like in mice, these findings open potential avenues towards improving muscle repair throughout life and have strong implications for regenerative medicine in muscle diseases.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Reference: Victoria Moiseeva, Andr\u00e9s Cisneros, Valentina Sica, Oleg Deryagin, Lai Yiwei, Sascha Jung, Eva Andr\u00e9s, Juan An, Jessica Segal\u00e9s, Laura Ortet, Vera Lukesova, Salvador Aznar-Benitah, Giacomo Volpe, Yasuteru Urano, Antonio del Sol, Miguel A. Esteban, Yasuyuki Ohkawa, Antonio L. Serrano, Eusebio Perdiguero, Pura Mu\u00f1oz-C\u00e1noves. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature<\/i>. 2022. DOI:10.1038\/s41586-022-05535-x<\/a><\/p>\n\n\n\n

\nPhoto: \u00a9 Fotolia<\/h5>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"

Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature in December.<\/p>\n","protected":false},"author":335,"featured_media":19144,"template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false},"news-category":[10],"news-topic":[26],"organisation":[209],"authorship":[335,44],"acf":[],"yoast_head":"\nHow damaged cells inhibit muscle regeneration over lifetime I Uni.lu<\/title>\n<meta name=\"description\" content=\"Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature in December.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How damaged cells inhibit muscle regeneration over lifetime\" \/>\n<meta property=\"og:description\" content=\"Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature in December.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/\" \/>\n<meta property=\"og:site_name\" content=\"UNI EN\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uni.lu\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-19T09:30:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1125\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/\"},\"author\":{\"name\":\"valentinadelgaudio\",\"@id\":\"https:\/\/www.uni.lu\/en\/#\/schema\/person\/0d4d61892313f40f3b9bb798f407531b\"},\"headline\":\"How damaged cells inhibit muscle regeneration over lifetime\",\"datePublished\":\"2022-12-19T14:58:00+00:00\",\"dateModified\":\"2025-02-19T09:30:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/\"},\"wordCount\":981,\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png\",\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/\",\"url\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/\",\"name\":\"How damaged cells inhibit muscle regeneration over lifetime I Uni.lu\",\"isPartOf\":{\"@id\":\"https:\/\/www.uni.lu\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png\",\"datePublished\":\"2022-12-19T14:58:00+00:00\",\"dateModified\":\"2025-02-19T09:30:00+00:00\",\"description\":\"Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature in December.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png\",\"width\":1500,\"height\":1125},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.uni.lu\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"News\",\"item\":\"https:\/\/www.uni.lu\/en\/news\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"How damaged cells inhibit muscle regeneration over lifetime\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.uni.lu\/en\/#website\",\"url\":\"https:\/\/www.uni.lu\/en\/\",\"name\":\"Uni.lu\",\"description\":\"University of Luxembourg\",\"publisher\":{\"@id\":\"https:\/\/www.uni.lu\/en\/#organization\"},\"alternateName\":\"University of Luxembourg\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.uni.lu\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.uni.lu\/en\/#organization\",\"name\":\"University of Luxembourg\",\"alternateName\":\"Uni.lu\",\"url\":\"https:\/\/www.uni.lu\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/www.uni.lu\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2026\/03\/03120157\/UNIV_SM-Profile_1600x1600px-scaled.jpg\",\"contentUrl\":\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2026\/03\/03120157\/UNIV_SM-Profile_1600x1600px-scaled.jpg\",\"width\":2560,\"height\":2560,\"caption\":\"University of Luxembourg\"},\"image\":{\"@id\":\"https:\/\/www.uni.lu\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uni.lu\",\"https:\/\/www.linkedin.com\/school\/university-of-luxembourg\/\",\"https:\/\/www.instagram.com\/uni.lu\",\"https:\/\/www.youtube.com\/@uni_lu\",\"https:\/\/en.wikipedia.org\/wiki\/University_of_Luxembourg\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.uni.lu\/en\/#\/schema\/person\/0d4d61892313f40f3b9bb798f407531b\",\"name\":\"valentinadelgaudio\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"How damaged cells inhibit muscle regeneration over lifetime I Uni.lu","description":"Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature in December.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/","og_locale":"en_GB","og_type":"article","og_title":"How damaged cells inhibit muscle regeneration over lifetime","og_description":"Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature in December.","og_url":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/","og_site_name":"UNI EN","article_publisher":"https:\/\/www.facebook.com\/uni.lu","article_modified_time":"2025-02-19T09:30:00+00:00","og_image":[{"width":1500,"height":1125,"url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimated reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#article","isPartOf":{"@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/"},"author":{"name":"valentinadelgaudio","@id":"https:\/\/www.uni.lu\/en\/#\/schema\/person\/0d4d61892313f40f3b9bb798f407531b"},"headline":"How damaged cells inhibit muscle regeneration over lifetime","datePublished":"2022-12-19T14:58:00+00:00","dateModified":"2025-02-19T09:30:00+00:00","mainEntityOfPage":{"@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/"},"wordCount":981,"publisher":{"@id":"https:\/\/www.uni.lu\/en\/#organization"},"image":{"@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage"},"thumbnailUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png","inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/","url":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/","name":"How damaged cells inhibit muscle regeneration over lifetime I Uni.lu","isPartOf":{"@id":"https:\/\/www.uni.lu\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage"},"image":{"@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage"},"thumbnailUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png","datePublished":"2022-12-19T14:58:00+00:00","dateModified":"2025-02-19T09:30:00+00:00","description":"Humans have a limited capacity for self-regeneration of tissues and organs but they do keep a pool of stem cells throughout their life that can self-renew and differentiate into specific cell types. These stem cells are widely studied as they could enable the repair of human tissues and thus have great potential for medicine. On the other hand, all human cells can enter a state called senescence: they stop multiplying but don\u2019t die, lingering within the tissue. As these senescent cells accumulate throughout the body, they can impact nearby healthy cells. An international team of researchers, including Prof. Antonio Del Sol from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from CIC bioGUNE-BRTA, recently explored the role of senescent cells in tissue regeneration. They uncovered key interactions between senescent cells and stem cells, opening potential avenues towards improving muscle repair throughout life. Their findings are published in Nature in December.","breadcrumb":{"@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#primaryimage","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2023\/11\/Placeholder_news.png","width":1500,"height":1125},{"@type":"BreadcrumbList","@id":"https:\/\/www.uni.lu\/en\/news\/how-damaged-cells-inhibit-muscle-regeneration-over-lifetime\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.uni.lu\/en\/"},{"@type":"ListItem","position":2,"name":"News","item":"https:\/\/www.uni.lu\/en\/news\/"},{"@type":"ListItem","position":3,"name":"How damaged cells inhibit muscle regeneration over lifetime"}]},{"@type":"WebSite","@id":"https:\/\/www.uni.lu\/en\/#website","url":"https:\/\/www.uni.lu\/en\/","name":"Uni.lu","description":"University of Luxembourg","publisher":{"@id":"https:\/\/www.uni.lu\/en\/#organization"},"alternateName":"University of Luxembourg","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.uni.lu\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/www.uni.lu\/en\/#organization","name":"University of Luxembourg","alternateName":"Uni.lu","url":"https:\/\/www.uni.lu\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.uni.lu\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2026\/03\/03120157\/UNIV_SM-Profile_1600x1600px-scaled.jpg","contentUrl":"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2026\/03\/03120157\/UNIV_SM-Profile_1600x1600px-scaled.jpg","width":2560,"height":2560,"caption":"University of Luxembourg"},"image":{"@id":"https:\/\/www.uni.lu\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uni.lu","https:\/\/www.linkedin.com\/school\/university-of-luxembourg\/","https:\/\/www.instagram.com\/uni.lu","https:\/\/www.youtube.com\/@uni_lu","https:\/\/en.wikipedia.org\/wiki\/University_of_Luxembourg"]},{"@type":"Person","@id":"https:\/\/www.uni.lu\/en\/#\/schema\/person\/0d4d61892313f40f3b9bb798f407531b","name":"valentinadelgaudio"}]}},"blog_id":9,"_links":{"self":[{"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/news\/40613"}],"collection":[{"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/types\/news"}],"author":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/users\/335"}],"version-history":[{"count":1,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/news\/40613\/revisions"}],"predecessor-version":[{"id":40614,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/news\/40613\/revisions\/40614"}],"wp:authorship":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/users\/335"},{"embeddable":true,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/users\/44"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/media\/19144"}],"wp:attachment":[{"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/media?parent=40613"}],"wp:term":[{"taxonomy":"news-category","embeddable":true,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/news-category?post=40613"},{"taxonomy":"news-topic","embeddable":true,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/news-topic?post=40613"},{"taxonomy":"organisation","embeddable":true,"href":"https:\/\/www.uni.lu\/en\/wp-json\/wp\/v2\/organisation?post=40613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}