{"id":20571,"date":"2022-03-09T23:15:04","date_gmt":"2022-03-09T22:15:04","guid":{"rendered":"https:\/\/www.uni.lu\/en\/events\/multiscale-simulation-approaches-for-probing-biomolecular-phase-behaviour\/"},"modified":"2022-03-09T23:15:04","modified_gmt":"2022-03-09T22:15:04","slug":"multiscale-simulation-approaches-for-probing-biomolecular-phase-behaviour","status":"publish","type":"events","link":"https:\/\/www.uni.lu\/en\/events\/multiscale-simulation-approaches-for-probing-biomolecular-phase-behaviour\/","title":{"rendered":"Multiscale simulation approaches for probing biomolecular phase behaviour"},"content":{"rendered":"<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\"><p><strong>Physics meets Biology Hybrid Seminar<\/strong><\/p><p>The interior of cells contains numerous components that need to be carefully organised in space to fulfil a wide range of biological functions. The most widespread form of intracellular compartments completely lack membranes. In the place of membranes, these compartments\u2014so called biomolecular condensates\u2014are sustained and segregated in space by the physical chemistry of liquid\u2013liquid phase separation. Complementary to experiments, molecular modelling and simulations have surfaced as powerful tools for providing us with the missing close-up views to understand the modulation of biomolecular phase behaviour. In this talk, I will describe the use of multiscale simulations to shed light on the molecular forces underlying biomolecular phase separation and account for salt-mediated reentrant phase transitions observed experimentally. I will explain how our simulations reveal distinctly different molecular driving forces stabilising condensates in the low and high-salt regime, highlighting that these interactions are not only dictated by the amino acid sequence but also crucially altered by the condensate environment. I will also discuss current efforts at developing transferable computer models that can predict biomolecular phase boundaries with quantitative accuracy.<\/p><p>Jerelle Joseph obtained her BSc in Mathematics and Chemistry and an MPhil in Chemistry from the University of the West Indies in Barbados. She then completed a PhD in Chemistry at the University of Cambridge, as a Gates Cambridge Scholar, in the group of Prof David Wales. She is currently a Research Fellow in Physical and Chemical Sciences at King\u2019s College in Cambridge and works in the group of Dr. Rosana Collepardo. Her research focuses on developing multiscale computational approaches to investigate cellular compartmentalisation via liquid-liquid phase separation.<\/p><\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>Physics meets Biology Hybrid Seminar<\/p>\n","protected":false},"author":0,"featured_media":20572,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","format":"standard","meta":{"featured_image_focal_point":[],"show_featured_caption":false,"ulux_newsletter_groups":"","uluxPostTitle":"","uluxPrePostTitle":"","_trash_the_other_posts":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"event_start_date":"2022-03-29 16:00:00","event_end_date":"2022-03-29 17:00:00","event_speaker_name":"Dr. Jerelle A. Joseph Research Fellow, King\u2019s College Cambridge, invited by Dr. Luke Davis","event_speaker_link":"","event_is_online":false,"event_location":"Campus Limpertsberg, B\u00e2timent des Sciences, BS 0.03","event_street":"","event_location_link":"","event_zip_code":"","event_city":"","event_country":"LU"},"events-topic":[320],"events-type":[],"organisation":[83,209],"authorship":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v22.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Multiscale simulation approaches for probing biomolecular phase behaviour - University of Luxembourg<\/title>\n<meta name=\"description\" content=\"Physics meets Biology Hybrid Seminar\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uni.lu\/en\/events\/multiscale-simulation-approaches-for-probing-biomolecular-phase-behaviour\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Multiscale simulation approaches for probing biomolecular phase behaviour\" \/>\n<meta property=\"og:description\" content=\"Physics meets Biology Hybrid Seminar\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uni.lu\/en\/events\/multiscale-simulation-approaches-for-probing-biomolecular-phase-behaviour\/\" \/>\n<meta property=\"og:site_name\" content=\"UNI EN\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uni.lu\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/9\/2022\/03\/multiscale_simulation_approaches_for_probing_biomolecular_phase_behaviour.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"531\" \/>\n\t<meta property=\"og:image:height\" content=\"708\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.uni.lu\/en\/events\/multiscale-simulation-approaches-for-probing-biomolecular-phase-behaviour\/\",\"url\":\"https:\/\/www.uni.lu\/en\/events\/multiscale-simulation-approaches-for-probing-biomolecular-phase-behaviour\/\",\"name\":\"Multiscale simulation approaches for probing biomolecular phase behaviour - 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